Phosphonoacetaldehyde reductase (NADH)

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Phosphonoacetaldehyde reductase (NADH)
Identifiers
EC no. 1.1.1.309
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Phosphonoacetaldehyde reductase (NADH) (EC 1.1.1.309, PhpC) is an enzyme with systematic name 2-hydroxyethylphosphonate:NAD+ oxidoreductase. [1] This enzyme catalyses the following chemical reaction

2-hydroxyethylphosphonate + NAD+ phosphonoacetaldehyde + NADH + H+

The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate.

Related Research Articles

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<span class="mw-page-title-main">6,7-dihydropteridine reductase</span> Class of enzymes

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In enzymology, a NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) is an enzyme that catalyzes the chemical reaction

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<span class="mw-page-title-main">NADH:ubiquinone reductase (non-electrogenic)</span> Class of enzymes

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References

  1. ↑ Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW (August 2007). "Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide". Nature Chemical Biology. 3 (8): 480–5. doi:10.1038/nchembio.2007.9. PMC   4313788 . PMID   17632514.
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