Phosphonoacetaldehyde reductase (NADH)

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Phosphonoacetaldehyde reductase (NADH)
Identifiers
EC no. 1.1.1.309
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
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NCBI proteins

Phosphonoacetaldehyde reductase (NADH) (EC 1.1.1.309, PhpC) is an enzyme with systematic name 2-hydroxyethylphosphonate:NAD+ oxidoreductase. [1] This enzyme catalyses the following chemical reaction

+ NAD+
 
 
 
H+
Phosphonoacetaldehyde reductase (NADH)
 
H+
 
+ NADH
 

The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonic acid. [2]

References

  1. Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW (August 2007). "Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide". Nature Chemical Biology. 3 (8): 480–5. doi:10.1038/nchembio.2007.9. PMC   4313788 . PMID   17632514.
  2. Enzyme 1.1.1.309 at KEGG Pathway Database.