Premnaspirodiene oxygenase

Premnaspirodiene oxygenase
Identifiers
EC no.	1.14.13.121
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Premnaspirodiene oxygenase (EC 1.14.13.121, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase. ^[1] This enzyme catalyses the following chemical reaction

(-)-vetispiradiene + 2 NADPH + 2 H⁺ + 2 O₂${\displaystyle \rightleftharpoons }$ solavetivone + 2 NADP⁺ + 3 H₂O (overall reaction)

(1a) (-)-vetispiradiene + NADPH + H⁺ + O₂${\displaystyle \rightleftharpoons }$ solavetivol + NADP⁺ + H₂O

(1b) solavetivol + NADPH + H⁺ + O₂${\displaystyle \rightleftharpoons }$ solavetivone + NADP⁺ + 2 H₂O

Premnaspirodiene oxygenase heme-thiolate protein (P-450).

References

1. Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J (October 2007). "Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates". The Journal of Biological Chemistry. 282 (43): 31744–54. doi: 10.1074/jbc.M703378200 . PMC   2695360 . PMID   17715131.

External links

• Premnaspirodiene+oxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)