Quinaldate 4-oxidoreductase

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quinaldate 4-oxidoreductase
Identifiers
EC no. 1.3.99.18
CAS no. 149885-77-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, quinaldate 4-oxidoreductase (EC 1.3.99.18) is an enzyme that catalyzes the chemical reaction

 
H2O
 
Quinaldate 4-oxidoreductase
H2O
 
 
+ reduced acceptor
 

The three substrates of this enzyme are quinaldic acid, an electron acceptor, and water. Its products are kynurenic acid and reduced acceptor. [1] [2] [3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating). This enzyme is also called quinaldic acid 4-oxidoreductase.

References

  1. Enzyme 1.3.99.18 at KEGG Pathway Database.
  2. Sauter M, Tshisuaka B, Fetzner S, Lingens F (1993). "Microbial metabolism of quinoline and related compounds. XX Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases". Biol. Chem. Hoppe-Seyler. 374 (11): 1037–46. doi:10.1515/bchm3.1993.374.7-12.1037. PMID   8292263.
  3. Fetzner S, Lingens F (1993). "Microbial metabolism of quinoline and related compounds. XVIII Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1". Biol. Chem. Hoppe-Seyler. 374 (6): 363–76. doi:10.1515/bchm3.1993.374.1-6.363. PMID   8357532.