Rabbit hemorrhagic disease

Last updated
Rabbit hemorrhagic disease virus
Emd-1933.jpg
CryoEM reconstruction of the virus capsid. EMDB entry EMD-1933 [1]
Virus classification OOjs UI icon edit-ltr.svg
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Picornavirales
Family: Caliciviridae
Genus: Lagovirus
Species:
Rabbit hemorrhagic disease virus
Isolates [2]
  • RHDV [FRG/89] (RHDV-FRG)
  • RCV [ITL/95] (RHDV-RCV)
  • RCV-A1 [MIC-07/2007/AU] (RHDV-RCV-A1)
  • RHDV [Ashington/1998/UK] (RHDV-Ash)
Synonyms
  • Lagovirus europeus GI
    Pendu et al., 2017 [3]
Rabbit Calicivirus CSIRO CSIRO ScienceImage 2009 Rabbit Calicivirus.jpg
Rabbit Calicivirus CSIRO

Rabbit hemorrhagic disease (RHD), also known as viral hemorrhagic disease (VHD), is a highly infectious and lethal form of viral hepatitis that affects European rabbits. Some viral strains also affect hares and cottontail rabbits. Mortality rates generally range from 70 to 100 percent. [4] The disease is caused by strains of rabbit hemorrhagic disease virus (RHDV), a lagovirus in the family Caliciviridae .

Contents

Rabbit hemorrhagic disease virus

Rabbit hemorrhagic disease virus (RHDV) is a virus in the genus Lagovirus and the family Caliciviridae. It is a nonenveloped virus with a diameter around 35–40 nm, icosahedral symmetry, and a linear positive-sense RNA genome of 6.4–8.5 kb. RHDV causes a generalized infection in rabbits that is characterized by necrosis of the liver, disseminated intravascular coagulation, and rapid death. Division into serotypes has been defined by a lack of cross-neutralization using specific antisera. [5] Rabbit lagoviruses also include related caliciviruses such as European brown hare syndrome virus. [6]

RHDV appears to have evolved from a pre-existing avirulent rabbit calicivirus (RCV). Nonpathogenic rabbit caliciviruses related to, but distinct from RHDV, had been circulating, apparently harmlessly, in Europe, Australia, and New Zealand prior to the emergence of RHDV. [7] [8] In the course of its evolution, RHDV split into six distinct genotypes, all of which are highly pathogenic. [8]

The three strains of rabbit hemorrhagic disease virus of medical significance are RHDV, RHDVa and RHDV2. RHDV (also referred to as RHDV, RHDV1, or as classical RHD) only affects adult European rabbits (Oryctolagus cuniculus). This virus was first reported in China in 1984, [9] from which it spread to much of Asia, Europe, Australia, and elsewhere. [10] A few isolated outbreaks of RHDV have occurred in the United States and Mexico, but they remained localized and were eradicated.[ citation needed ]

In 2010, a new lagovirus with a distinct antigenic profile was identified in France. The new virus, named rabbit hemorrhagic disease virus type 2 (abbreviated as RHDV2 or RHDVb), also caused RHD, but exhibited distinctive genetic, antigenic, and pathogenic features. Importantly, RHDV2 killed rabbits previously vaccinated with RHDV vaccines, and affected young European rabbits, as well as hares (Lepus spp.). [11] All these features strongly suggest that the virus was not derived from RHDVa, but from some other unknown source. [4] RHDV2 has since spread to the majority of Europe, as well as to Australia, Canada, [12] and the United States. [13] [14]

Epidemiology and transmission

Both viruses causing RHD are extremely contagious. Transmission occurs by direct contact with infected animals, carcasses, bodily fluids (urine, feces, respiratory secretions), and hair. Surviving rabbits may be contagious for up to 2 months. [6] Contaminated fomites such as clothing, food, cages, bedding, feeders, and water also spread the virus. Flies, fleas, and mosquitoes can carry the virus between rabbits. [10] Predators and scavengers can also spread the virus by shedding it in their feces. [10] Caliciviruses are highly resistant in the environment, and can survive freezing for prolonged periods. The virus can persist in infected meat for months, and for prolonged periods in decomposing carcasses. Importation of rabbit meat may be a major contributor in the spread of the virus to new geographic regions. [6]

RHD outbreaks tend to be seasonal in wild rabbit populations, where most adults have survived infection and are immune. As young kits grow up and stop nursing, they no longer receive the antibodies provided in their mother's milk and become susceptible to infection. Thus, RHD epizootics occur more often during the rabbits' breeding season. [10]

Generally, high host specificity exists among lagoviruses. [6] Classic RHDVa only affects European rabbits, a species native to Europe and from which the domestic rabbit is descended. The new variant RHDV2 affects European rabbits, as well, but also causes fatal RHD in various Lepus species, including Sardinian Cape hares (L. capensis mediterraneus), Italian hares (L. corsicanus), and mountain hares (L. timidus). [15] Reports of RHD in Sylvilagus species have been coming from the current outbreak in the United States. [16]

RHD caused by RHDV and RHDVa demonstrates high morbidity (up to 100%) and mortality (40-100%) in adult European rabbits. Young rabbits 6–8 weeks old are less likely to be infected, and kits younger than 4 weeks old do not become ill. [6] The more recently emerged RHDV2 causes death and disease in rabbits as young as 15 days old. Mortality rates from RHDV2 are more variable at 5-70%. Initially less virulent, the pathogenicity of RHDV2 has been increasing and is now similar to that found with RHDV and RHDVa. Deaths from RHDV2 have been confirmed in rabbits previously vaccinated against RHDVa. [6]

Pathophysiology

These viruses replicate in the liver and by mechanisms not fully elucidated, trigger the mass death of hepatocytes which can in turn lead to disseminated intravascular coagulation, hepatic encephalopathy, and nephrosis. [10] Bleeding may occur, as clotting factors and platelets are used up.

Clinical signs

European rabbit with ocular jaundice Rabbit with jaundice (eye).jpg
European rabbit with ocular jaundice

The incubation period for RHDVa is 1–2 days, and for RHDV2 3–5 days. Rabbits infected with RHDV2 are more likely to show subacute or chronic signs than are those infected with RHDVa. [6] In rabbitries, an epidemic with high mortality rates in adult and subadult rabbits is typical. [10] If the outbreak is caused by RHDV2, then deaths also occur in young rabbits.[ citation needed ]

RHD can vary in the rate clinical signs occur. In peracute cases, rabbits are usually found dead with no premonitory symptoms. [15] Rabbits may be observed grazing normally immediately before death. [10]

In acute cases, rabbits are inactive and reluctant to move. They may develop a fever up to 42 °C (107.6 °F) and have increased heart and respiratory rates. Bloody discharge from the nose, mouth, or vulva is common, as is blood in the feces or urine. Lateral recumbency, coma, and convulsions may be observed before death. [10] Rabbits with the acute form generally die within 12 to 36 hours from the onset of fever. [15]

Subacute to chronic RHD has a more protracted clinical course, and is more commonly noted with RHDV2 infections. Clinical signs include lethargy, anorexia, weight loss, and jaundice. Gastrointestinal dilation, cardiac arrhythmias, heart murmurs, and neurologic abnormalities can also occur. [6] Death, if it occurs, usually happens 1–2 weeks after the onset of symptoms, and is due to liver failure. [15]

Not all rabbits exposed to RHDVa or RHDV2 become overtly ill. A small proportion of infected rabbits clears the virus without developing signs of disease. [10] Asymptomatic carriers also occur, and can continue to shed virus for months, thereby infecting other animals. Surviving rabbits develop a strong immunity to the specific viral variant with which they were infected. [6]

Diagnosis

A presumptive diagnosis of RHD can often be made based on clinical presentation, infection pattern within a population, and post mortem lesions. Definitive diagnosis requires detection of the virus. As most caliciviruses cannot be grown in cell culture, antibody and nucleic acid based methods of viral detection are often used. [6]

Complete blood counts from rabbits with RHD often show low levels of white blood cells and platelets, and chemistry panels show elevated liver enzymes. Evidence of liver failure may also be present, including increased bile acids and bilirubin, and decreased glucose and cholesterol. Prolonged prothrombin and activated partial thromboplastin times are typical. Urinalysis can show bilirubinuria, proteinuria, and high urinary GGT. [6]

The classic post mortem lesion seen in rabbits with RHD is extensive hepatic necrosis. Multifocal hemorrhages, splenomegaly, bronchopneumonia, pulmonary hemorrhage or edema, and myocardial necrosis may sometimes also be seen. [6]

RT-qPCR tests are a commonly used and accurate testing modality for RNA-based viruses. Other tests used include enzyme-linked immunosorbent assay, electron microscopy, immunostaining, Western blot, and in situ hybridization. [6] The tissue of choice for molecular testing is fresh or frozen liver, as it usually contains the largest numbers of virus, but if this is not available, spleen and serum can also be used. Identification of the strain of RHDV is needed so vaccination protocols can be adjusted accordingly.[ citation needed ]

Prevention and control

Vaccines

A number of vaccines available against RHD are sold in countries where the disease is endemic. All provide 12 months of protection against RHD viruses. Because RHD viruses cannot normally be grown in vitro , [17] how these vaccines are produced is affected. Inactivated RHD vaccines, including Eravac, [18] Felavac, and Cylap, are "liver-derived", meaning that laboratory rabbits are intentionally infected with RHD and their livers and spleens harvested to make vaccines. Each rabbit used results in the production of thousands of vaccine doses. This has led to controversy among rabbit lovers, who question the ethics of some rabbits having to die to protect others [19] but is not an issue where rabbits are primarily farmed for meat. Another method of reproducing the virus is through recombinant technology, where antigenic portions of the RHD viruses are inserted into viruses that can be grown in culture. This is the method used to create Nobivac Myxo-RHD PLUS. [20]

Vaccines against only the classic RHDVa strain are: Cylap RCD Vaccine, made by Zoetis, [21] protects rabbits from two different strains of RHDVa (v351 and K5) that are used for wild rabbit control in Australia. [22] CUNIPRAVAC RHD, [23] manufactured by HIPRA, protects against the RHDVa strains found in Europe. Nobivac Myxo-RHD, [24] made by MSD Animal Health, is a live myxoma-vectored vaccine that offers one-year duration of immunity against both RHDVa and myxomatosis.[ citation needed ]

Vaccines against only the newer RHDV2 strain are: Eravac vaccine, manufactured by HIPRA, [25] protects rabbits against RHDV2 for a year.

Vaccines that protect against both RHDVa and RHDV2 strains include: Filavac VHD K C+V, [26] manufactured by Filavie, protects against both classical RHDVa and RHDV-2. [27] It is available in single dose and multidose vials. A soon-to-be-released vaccine from MSD Animal Health, Nobivac Myxo-RHD PLUS, is a live recombinant vector vaccine active against both RHDVa and RHDV2, as well as myxomatosis. [28]

Countries in which RHD is not considered endemic may place restrictions on importation of RHDV vaccines. Importation of these vaccines into the United States can only be done with the approval of the United States Department of Agriculture [29] and the appropriate state veterinarian. [30]

Disinfection

Caliciviruses are stable in the environment and difficult to inactivate. Products commonly used for household disinfection such as Clorox and Lysol disinfecting wipes do not work against these viruses. One effective option is to wipe down surfaces with a 10% bleach solution, allowing 10 minutes of contact time before rinsing. Other disinfectants shown to work include 10% sodium hydroxide, 2% One-Stroke Environ, Virkon S, Clorox Healthcare Bleach Germicidal Wipes, Trifectant, Rescue, and hydrogen peroxide cleaners. Surface debris must always be mechanically removed prior to disinfection. A list of disinfectants that are effective against calicivirus (in this case norovirus) can be found on the Environmental Protection Agency's website. [31] Studies have shown that many quaternary ammonium compound based disinfectants do not inactivate caliciviruses. [32]

Quarantine and other measures

Because of the highly infectious nature of the disease, strict quarantine is necessary when outbreaks occur. Depopulation, disinfection, vaccination, surveillance, and quarantine are the only way to properly and effectively eradicate the disease. Deceased rabbits must be removed immediately and discarded in a safe manner. Surviving rabbits should be quarantined or humanely euthanized. Test rabbits may be used to monitor the virus on vaccinated farms. [33]

Geographic distribution

RHD is primarily a disease affecting European rabbits, which are native to the Iberian Peninsula and are found in the wild in much of Western Europe. Domesticated breeds are farmed throughout the world for meat and fur, and are becoming increasingly popular pets. European rabbits have been introduced to and become feral and sometimes invasive in Australia, New Zealand, Chile, Argentina, and various islands. [8]

RHD was first reported in 1984 in the People's Republic of China. Since then, RHD has spread to over 40 countries in Africa, the Americas, Asia, Europe, and Oceania, and is endemic in most parts of the world. [34]

In 2010, a new virus variant called rabbit hemorrhagic disease virus 2 (RHDV2) emerged in France. [35] RHDV2 has since spread from France to the rest of Europe, Great Britain, Australia, and New Zealand. Outbreaks started occurring in the United States and Vancouver Island Canada in 2019.

Asia

China

The first reported outbreak of RHD caused by RHDVa occurred in 1984 in the Jiangsu Province of the Mainland China. [9] The outbreak occurred in a group of Angora rabbits that had been imported from Germany. The cause of the disease was determined to be a small, nonenveloped RNA virus. An inactivated vaccine was developed that proved effective in preventing disease. [9] In less than a year, the disease spread over an area of 50,000 km2 in China and killed 140 million domestic rabbits. [36]

South Korea

South Korea was the next country to report RHD outbreaks following the importation of rabbit fur from Mainland China. [36] [37] RHD has since spread to and become endemic in many countries in Asia, including India and the Middle East.[ citation needed ]

Europe

From China, RHDVa spread westward to Europe. The first report of RHD in Europe came from in Italy in 1986. [36] From there, it spread to much of Europe. Spain's first reported case was in 1988, [36] and France, Belgium, and Scandinavia followed in 1990. Spain experienced a large die-off of wild rabbits, which in turn caused a population decline in predators that normally ate rabbits, including the Iberian lynx and Spanish imperial eagle. [38] [39]

United Kingdom

RHD caused by RHDVa was reported for the first time in the United Kingdom in 1992. [40] This initial epidemic was brought under control in the late 1990s using a combination of vaccination, strict biosecurity, and good husbandry. [15] The newer viral strain RHDV2 was first detected in England and Wales in 2014, and soon spread to Scotland and Ireland. [15]

Finland

RHD was detected for the first time in Finland in 2016. The outbreak occurred in feral European rabbits, and genetic testing identified the viral strain as RHDV2. Cases of viral transmission to domesticated pet rabbits have been confirmed, and vaccinating rabbits has been recommended. [41]

Oceania

Australia

In 1991, a strain of the RHDVa virus, Czech CAPM 351RHDV, was imported to Australia [42] under strict quarantine conditions to research the safety and usefulness of the virus if it were used as a biological control agent against Australia and New Zealand's rabbit pest problem. Testing of the virus was undertaken on Wardang Island in Spencer Gulf off the coast of the Yorke Peninsula, South Australia. In 1995, the virus escaped quarantine and subsequently killed 10 million rabbits within 8 weeks of its release. [43] In March 2017, a new Korean strain known as RHDV K5 was successfully released in a deliberate manner after almost a decade of research. This strain was chosen in part because it functions better in cool, wet regions where the previous Calicivirus was less effective. [44]

New Zealand

In July 1997, after considering over 800 public submissions, the New Zealand Ministry of Health decided not to allow RHDVa to be imported into New Zealand to control rabbit populations. However, in late August, RHDVa was confirmed to have been deliberately and illegally introduced to the Cromwell area of the South Island. An unsuccessful attempt was made by New Zealand officials to control the spread of the disease. It was, however, being intentionally spread, and several farmers (notably in the Mackenzie Basin area) admitted to processing rabbits that had died from the disease in kitchen blenders for further spreading. Had the disease been introduced at a better time, control of the population would have been more effective, but it was released after breeding had commenced for the season, and rabbits under 2 weeks old at the time of the introduction were resistant to the disease. These young rabbits were, therefore, able to survive and breed rabbit numbers back up. Ten years on, rabbit populations (in the Mackenzie Basin in particular) are beginning to reach near preplague proportions once again, though they have not yet returned to pre-RHD levels. [45] [46] Resistance to RHD in New Zealand rabbits has led to the widespread use of Compound 1080 (Sodium fluoroacetate). The government and department of conservation are having to increase their use of 1080 to protect reserve land from rabbits and preserve the gains made in recent years through the use of RHD. [47]

North and South America

United States and Canada

Isolated outbreaks of RHDVa in domestic rabbits have occurred in the United States, the first of which was in Iowa in 2000. [48] In 2001, outbreaks occurred in Utah, Illinois, and New York. [49] [50] [51] More recent outbreaks of RHDVa have occurred in 2005 in Indiana and 2018 in Pennsylvania. [52] [53] Each of these outbreaks was contained and was the result of separate but indeterminable introductions of RHDVa. [10] RHDVa does not affect the native cottontail and jackrabbits in the United States, so the virus did not become endemic. [33]

The first report of RHDV2 virus in North America was on a farm in Québec, in 2016. In 2018, a larger outbreak occurred in feral European rabbits on Delta and Vancouver Island, British Columbia. [54] The disease was confirmed later that year in a pet rabbit in Ohio. [55] In July 2019, the first case of RHDV2 in Washington was confirmed in a pet rabbit from Orcas Island. [56] RHDV2 have been reported in domestic rabbits in Washington and New York.[ citation needed ]

In 2020, outbreaks of the disease in domestic rabbits, as well as cottontail rabbits and hares, have been reported in Arizona, New Mexico, Colorado, Texas, Nevada, California and Utah. [57] Affected wildlife include mountain cottontail rabbits (Sylvilagus nutalli), desert cottontail rabbits (S. audubonii), antelope jackrabbits (L. alleni), and black-tailed jackrabbits (L. californicus). [58] The virus circulating in the Southwest United States is distinct from the RHDV2 isolated from New York, Washington, Ohio, and British Columbia, Canada. [58] The sources of these outbreaks are unknown. [58]

In June 2022, a case occurred in Hawaii. It was first confirmed in a neutered hare on Maui. Department of Agriculture inspectors began testing after becoming aware of 9 rabbit deaths on a Maui farm. [59]

Mexico

Mexico experienced an outbreak of RHDVa in domestic rabbits from 1989 to 1991, presumably following the importation of rabbit meat from the People's Republic of China. [60] Strict quarantine and depopulation measures were able to eradicate the virus, and the country was officially declared to be RHD-free in 1993. [61]

A second outbreak of RHD in domestic rabbits began in the state of Chihuahua in April 2020 and has since spread to Sonora, Baja California, Baja California Sur, Coahuila, and Durango. [62] As of 2021 and 2022, a RHD outbreak occurred in Hidalgo and the Mexico City Metropolitan Area. [63] [64] A mass disinfectant and vaccination campaign was ordered by the Directorate of Agricultural Development and over 390 thousand rabbits have received vaccinations. [65] [66] It has been confirmed ever since then, that the disease is present In Central Mexico. [67]

Cuba

Since 1993, RHDVa has been endemic in Cuba. Four epizootics involving domesticated rabbits were reported in 1993, 1997, 2000–2001, and 2004–2005. As consequence, thousands of rabbits have died or have been slaughtered each time. [68]

Bolivia

The virus is also believed to be present in Bolivia.[ citation needed ]

See also

Related Research Articles

<span class="mw-page-title-main">Bluetongue disease</span> Viral disease in animals

Bluetongue disease is a noncontagious, insect-borne, viral disease of ruminants, mainly sheep and less frequently cattle, yaks, goats, buffalo, deer, dromedaries, and antelope. It is caused by Bluetongue virus (BTV). The virus is transmitted by the midges Culicoides imicola, Culicoides variipennis, and other culicoids.

<span class="mw-page-title-main">Rift Valley fever</span> Human and livestock viral disease

Rift Valley fever (RVF) is a viral disease of humans and livestock that can cause mild to severe symptoms. The mild symptoms may include: fever, muscle pains, and headaches which often last for up to a week. The severe symptoms may include: loss of sight beginning three weeks after the infection, infections of the brain causing severe headaches and confusion, and bleeding together with liver problems which may occur within the first few days. Those who have bleeding have a chance of death as high as 50%.

<span class="mw-page-title-main">Marburg virus disease</span> Human viral disease

Marburg virus disease (MVD), formerly Marburg hemorrhagic fever (MHF) is a viral hemorrhagic fever in human and non-human primates caused by either of the two Marburgviruses: Marburg virus (MARV) and Ravn virus (RAVV). Its clinical symptoms are very similar to those of Ebola virus disease (EVD).

<span class="mw-page-title-main">Myxomatosis</span> Rabbit disease caused by Myxoma virus

Myxomatosis is a disease caused by Myxoma virus, a poxvirus in the genus Leporipoxvirus. The natural hosts are tapeti in South and Central America, and brush rabbits in North America. The myxoma virus causes only a mild disease in these species, but causes a severe and usually fatal disease in European rabbits, the species of rabbit commonly raised for companionship and as a food source.

Classical swine fever (CSF) or hog cholera is a highly contagious disease of swine. It has been mentioned as a potential bioweapon.

<span class="mw-page-title-main">Virulent Newcastle disease</span> Contagious viral avian disease

Virulent Newcastle disease (VND), formerly exotic Newcastle disease, is a contagious viral avian disease affecting many domestic and wild bird species; it is transmissible to humans. Though it can infect humans, most cases are non-symptomatic; rarely it can cause a mild fever and influenza-like symptoms and/or conjunctivitis in humans. Its effects are most notable in domestic poultry due to their high susceptibility and the potential for severe impacts of an epizootic on the poultry industries. It is endemic to many countries. No treatment for VND is known, but the use of prophylactic vaccines and sanitary measures reduces the likelihood of outbreaks.

<i>Caliciviridae</i> Family of viruses

The Caliciviridae are a family of "small round structured" viruses, members of Class IV of the Baltimore scheme. Caliciviridae bear resemblance to enlarged picornavirus and was formerly a separate genus within the picornaviridae. They are positive-sense, single-stranded RNA which is not segmented. Thirteen species are placed in this family, divided among eleven genera. Diseases associated with this family include feline calicivirus, rabbit hemorrhagic disease virus, and Norwalk group of viruses (gastroenteritis). Caliciviruses naturally infect vertebrates, and have been found in a number of organisms such as humans, cattle, pigs, cats, chickens, reptiles, dolphins and amphibians. The caliciviruses have a simple construction and are not enveloped. The capsid appears hexagonal/spherical and has icosahedral symmetry with a diameter of 35–39 nm.

<span class="mw-page-title-main">Viral hemorrhagic fever</span> Type of illnesses

Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses. VHFs may be caused by five distinct families of RNA viruses: the families Filoviridae, Flaviviridae, Rhabdoviridae, and several member families of the Bunyavirales order such as Arenaviridae, and Hantaviridae. All types of VHF are characterized by fever and bleeding disorders and all can progress to high fever, shock and death in many cases. Some of the VHF agents cause relatively mild illnesses, such as the Scandinavian nephropathia epidemica, while others, such as Ebola virus, can cause severe, life-threatening disease.

<span class="mw-page-title-main">Crimean–Congo hemorrhagic fever</span> Disease of humans and other animals

Crimean–Congo hemorrhagic fever (CCHF) is a viral disease. Symptoms of CCHF may include fever, muscle pains, headache, vomiting due to loss of net saline of basal cells, diarrhea, and bleeding into the skin. Onset of symptoms is less than two weeks following exposure. Complications may include liver failure. Survivors generally recover around two weeks after onset.

<span class="mw-page-title-main">Canine influenza</span> Influenza occurring in canines

Canine influenza is influenza occurring in canine animals. Canine influenza is caused by varieties of influenzavirus A, such as equine influenza virus H3N8, which was discovered to cause disease in canines in 2004. Because of the lack of previous exposure to this virus, dogs have no natural immunity to it. Therefore, the disease is rapidly transmitted between individual dogs. Canine influenza may be endemic in some regional dog populations of the United States. It is a disease with a high morbidity but a low incidence of death.

Aujeszky's disease, usually called pseudorabies in the United States, is a viral disease in swine that is endemic in most parts of the world. It is caused by Suid herpesvirus 1 (SuHV-1). Aujeszky's disease is considered to be the most economically important viral disease of swine in areas where classical swine fever has been eradicated. Other mammals, such as cattle, sheep, goats, cats, dogs, and raccoons, are also susceptible. The disease is usually fatal in these animal species.

<i>Feline calicivirus</i> Species of virus

Feline calicivirus (FCV) is a virus of the family Caliciviridae that causes disease in cats. It is one of the two important viral causes of respiratory infection in cats, the other being Felid alphaherpesvirus 1. FCV can be isolated from about 50% of cats with upper respiratory infections. Cheetahs are the other species of the family Felidae known to become infected naturally.

<i>African swine fever virus</i> Species of virus

African swine fever virus (ASFV) is a large, double-stranded DNA virus in the Asfarviridae family. It is the causative agent of African swine fever (ASF). The virus causes a hemorrhagic fever with high mortality rates in domestic pigs; some isolates can cause death of animals as quickly as a week after infection. It persistently infects its natural hosts, warthogs, bushpigs, and soft ticks of the genus Ornithodoros, which likely act as a vector, with no disease signs. It does not cause disease in humans. ASFV is endemic to sub-Saharan Africa and exists in the wild through a cycle of infection between ticks and wild pigs, bushpigs, and warthogs. The disease was first described after European settlers brought pigs into areas endemic with ASFV, and as such, is an example of an emerging infectious disease.

<span class="mw-page-title-main">Bovine malignant catarrhal fever</span> Species of virus

Bovine malignant catarrhal fever (BMCF) is a fatal lymphoproliferative disease caused by a group of ruminant gamma herpes viruses including Alcelaphine gammaherpesvirus 1 (AlHV-1) and Ovine gammaherpesvirus 2 (OvHV-2) These viruses cause unapparent infection in their reservoir hosts, but are usually fatal in cattle and other ungulates such as deer, antelope, and buffalo. In Southern Africa the disease is known as snotsiekte, from the Afrikaans.

<span class="mw-page-title-main">Viral hemorrhagic septicemia</span> Disease of fish

Viral hemorrhagic septicemia (VHS) is a deadly infectious fish disease caused by Viral hemorrhagic septicemia virus. It afflicts over 50 species of freshwater and marine fish in several parts of the Northern Hemisphere. Different strains of the virus occur in different regions, and affect different species. There are no signs that the disease affects human health. VHS is also known as Egtved disease, and the virus as Egtved virus.

Equine viral arteritis (EVA) is a disease of horses caused by a virus of the species Alphaarterivirus equid, an RNA virus. It is the only species in the genus Alphaarterivirus, and that is the only genus in the Equarterivirinae subfamily. The virus which causes EVA was first isolated in 1953, but the disease has afflicted equine animals worldwide for centuries. It has been more common in some breeds of horses in the United States, but there is no breed "immunity". In the UK, it is a notifiable disease. There is no known human hazard.

<span class="mw-page-title-main">Foot-and-mouth disease</span> Infectious disease affecting cattle

Foot-and-mouth disease (FMD) or hoof-and-mouth disease (HMD) is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, including domestic and wild bovids. The virus causes a high fever lasting two to six days, followed by blisters inside the mouth and near the hoof that may rupture and cause lameness.

Spring viraemia of carp, also known as swim bladder inflammation, is caused by Carp sprivivirus, also called Rhabdovirus carpio. It is listed as a notifiable disease under the World Organisation for Animal Health.

<span class="mw-page-title-main">Ebola</span> Viral hemorrhagic fever of humans and other primates caused by ebolaviruses

Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after infection. The first symptoms are usually fever, sore throat, muscle pain, and headaches. These are usually followed by vomiting, diarrhoea, rash and decreased liver and kidney function, at which point some people begin to bleed both internally and externally. It kills between 25% and 90% of those infected – about 50% on average. Death is often due to shock from fluid loss, and typically occurs between six and 16 days after the first symptoms appear. Early treatment of symptoms increases the survival rate considerably compared to late start. An Ebola vaccine was approved by the US FDA in December 2019.

<span class="mw-page-title-main">Rabbit health</span> Health of rabbits

The health of rabbits is well studied in veterinary medicine, owing to the importance of rabbits as laboratory animals and centuries of domestication for fur and meat.

References

  1. ↑ Luque, D; González, JM; Gómez-Blanco, J; et al. (2012). "Epitope Insertion at the N-Terminal Molecular Switch of the Rabbit Hemorrhagic Disease Virus T=3 Capsid Protein Leads to Larger T=4 Capsids". Journal of Virology. 86 (12): 6470–6480. doi:10.1128/JVI.07050-11. PMC   3393579 . PMID   22491457.
  2. ↑ "ICTV 9th Report (2011) Caliciviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 9 January 2019.[ dead link ]
  3. ↑ Le Pendu, J.; et al. (2017). "Proposal for a unified classification system and nomenclature of lagoviruses". The Journal of General Virology. 98 (7): 1658–1666. doi: 10.1099/jgv.0.000840 . PMID   28714849.
  4. 1 2 Capucci, L; Cavadini, P; Schiavitto, M; et al. (2017). "Increased pathogenicity in rabbit haemorrhagic disease virus type 2 (RHDV2)". Veterinary Record. 180 (17): 426. doi: 10.1136/vr.104132 . PMID   28341721.
  5. ↑ "Caliciviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 4 May 2020.
  6. 1 2 3 4 5 6 7 8 9 10 11 12 13 Gleeson, M; Petritz, OA (May 2020). "Emerging Infectious Diseases of Rabbits". Veterinary Clinics of North America: Exotic Animal Practice. 23 (2): 249–261. doi:10.1016/j.cvex.2020.01.008. PMID   32327034. S2CID   216109069.
  7. ↑ Capucci, L; Fusi, P; Lavazza, A; et al. (December 1996). "Detection and preliminary characterization of a new rabbit calicivirus related to rabbit hemorrhagic disease virus but nonpathogenic". Journal of Virology. 70 (12): 8614–8623. doi: 10.1128/JVI.70.12.8614-8623.1996 . PMC   190954 . PMID   8970986.
  8. 1 2 3 Kerr, PJ; Kitchen, A; Holmes, EC (2009). "Origin and Phylodynamics of Rabbit Hemorrhagic Disease Virus". Journal of Virology. 83 (23): 12129–12138. doi:10.1128/JVI.01523-09. PMC   2786765 . PMID   19759153.
  9. 1 2 3 Liu, SJ; Xue, HP; Pu, BQ; et al. (1984). "A new viral disease in rabbits". Animal Husbandry and Veterinary Medicine (Xumu Yu Shouyi). 16 (6): 253–255.
  10. 1 2 3 4 5 6 7 8 9 10 Kerr, PJ; Donnelly, TM (May 2013). "Viral Infections of Rabbits". Veterinary Clinics of North America: Exotic Animal Practice. 16 (2): 437–468. doi:10.1016/j.cvex.2013.02.002. PMC   7110462 . PMID   23642871.
  11. ↑ Bárcena, J; Guerra, B; Angulo, I; et al. (2015). "Comparative analysis of rabbit hemorrhagic disease virus (RHDV) and new RHDV2 virus antigenicity, using specific virus-like particles". Veterinary Research. 46 (1): 106. doi: 10.1186/s13567-015-0245-5 . PMC   4581117 . PMID   26403184.
  12. ↑ Ambagala, Aruna; Schwantje, Helen; Laurendeau, Sonja; Snyman, Heindrich; Joseph, Tomy; Pickering, Bradley; Hooper-McGrevy, Kathleen; Babiuk, Shawn; Moffat, Estella; Lamboo, Lindsey; Lung, Oliver; Goolia, Melissa; Pinette, Mathieu; Embury-Hyatt, Carissa (2021-05-26). "Incursions of rabbit haemorrhagic disease virus 2 in Canada—Clinical, molecular and epidemiological investigation". Transboundary and Emerging Diseases. 68 (4): 1711–1720. doi: 10.1111/tbed.14128 . ISSN   1865-1674. PMID   33915034.
  13. ↑ "Rabbit hemorrhagic disease". American Veterinary Medical Association . Retrieved 2022-08-07.
  14. ↑ "Deadly rabbit disease confirmed in Thurston County; vets urge vaccination". Washington State Department of Agriculture . 2020-09-25. Retrieved 2022-08-07.
  15. 1 2 3 4 5 6 Rocchi, MS; Dagleish, MP (2018). "Diagnosis and prevention of rabbit viral haemorrhagic disease 2". In Practice. 40 (1): 11–16. doi:10.1136/inp.k54. S2CID   80154118.
  16. ↑ Fiala, Jennifer (2 August 2008). "Southwest US faces lethal rabbit disease outbreak". Vin.com. Retrieved 21 April 2020.
  17. ↑ Zhu, J; Miao, Q; Tan, Y; et al. (2017). "Inclusion of an Arg-Gly-Asp receptor-recognition motif into the capsid protein of rabbit hemorrhagic disease virus enables culture of the virus". Journal of Biological Chemistry. 292 (21): 8605–8615. doi: 10.1074/jbc.M117.780924 . PMC   5448090 . PMID   28381555.
  18. ↑ "CVMP assessment report for ERAVAC" (PDF). Committee for Medicinal Products for Veterinary Use, European Medicines Agency. Retrieved 1 May 2020.
  19. ↑ "HRS RHDV2 Vaccine Ethics Statement | House Rabbit Society". House Rabbit Society. Archived from the original on 2020-05-16. Retrieved 1 May 2020.
  20. ↑ Francisco, EM (13 September 2019). "Nobivac Myxo-RHD Plus". European Medicines Agency. Retrieved 1 May 2020.
  21. ↑ "Cylap RCD Vaccine". www.zoetis.com.au. Retrieved 25 April 2020.
  22. ↑ Read, AJ; Kirkland, PD (July 2017). "Efficacy of a commercial vaccine against different strains of rabbit haemorrhagic disease virus". Australian Veterinary Journal. 95 (7): 223–226. doi:10.1111/avj.12600. PMID   28653381. S2CID   5123892.
  23. ↑ "CUNIPRAVAC RHD". HiPRA. Retrieved 25 April 2020.
  24. ↑ "Nobivac Myxo RHD | Overview". MSD Animal Health. Retrieved 26 April 2020.
  25. ↑ "Eravac". NOAH Compendium. Retrieved 26 April 2020.
  26. ↑ "Filavac VHD K C+V". NOAH Compendium. Retrieved 26 April 2020.
  27. ↑ Le Minor, O.; Boucher, S.; Joudou, L.; Mellet, R.; Sourice, M.; Le Moullec, T.; Nicolier, A.; Beilvert, F.; Sigognault-Flochlay, A. (2019). "Rabbit haemorrhagic disease: experimental study of a recent highly pathogenic GI.2/RHDV2/b strain and evaluation of vaccine efficacy". World Rabbit Science. 27 (3): 143. doi: 10.4995/wrs.2019.11082 . hdl: 10251/126955 .
  28. ↑ "Nobivac Myxo-RHD PLUS". NOAH Compendium. Retrieved 26 April 2020.
  29. ↑ "APHIS Form 2005" (PDF). USDA APHIS. Retrieved 26 April 2020.
  30. ↑ "State Animal Health Officials" (PDF). USAHA. Retrieved 26 April 2020.
  31. ↑ "EPA's registered antimicrobial products effective against Norovirus". US Environmental Protection Agency. 28 September 2015. Retrieved 12 May 2020.
  32. ↑ Kennedy, MA; Mellon, VS; Caldwell, G; et al. (1995). "Virucidal efficacy of the newer quaternary ammonium compounds". Journal of the American Animal Hospital Association . 31 (3): 254–258. doi:10.5326/15473317-31-3-254. PMID   7634062.
  33. 1 2 Spickler, Anna. "Rabbit Hemorrhagic Disease" (PDF). The Center for Food Security and Public Health. Retrieved 27 April 2020.
  34. ↑ "Rabbit haemorrhagic disease" (PDF). OIE Technical Disease Cards. Retrieved 27 April 2020.
  35. ↑ Le Gall-Reculé, G; Lavazza, A; Marchandeau, S; et al. (2013). "Emergence of a new lagovirus related to rabbit haemorrhagic disease virus". Veterinary Research. 44 (1): 81. doi: 10.1186/1297-9716-44-81 . PMC   3848706 . PMID   24011218.
  36. 1 2 3 4 Abrantes, J; van der Loo, W; Le Pendu, J; et al. (2012). "Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): a review". Veterinary Research. 43 (1): 12. doi: 10.1186/1297-9716-43-12 . PMC   3331820 . PMID   22325049.
  37. ↑ Lee, CS; Park, CK; Shin, TK; et al. (1990). "An outbreak of rabbit sudden death in Korea suspected of a new viral hepatitis". The Japanese Journal of Veterinary Science. 52 (5): 1135–1137. doi: 10.1292/jvms1939.52.1135 . PMID   2280498.
  38. ↑ "Iberian Lynx Depends On Rabbits for Survival". Science Daily. 5 July 2011.
  39. ↑ Platt, JR (12 July 2011). "Deadly Rabbit Disease May Have Doomed Iberian Lynx". Scientific American.
  40. ↑ Chasey, D (1994). "Possible origin of rabbit haemorrhagic disease in the United Kingdom". Veterinary Record. 135 (21): 469–499. doi:10.1136/vr.135.21.496 (inactive 2024-11-14). PMID   7871688. S2CID   32592717.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
  41. ↑ Isomursu, M; Neimanis, A; Karkamo, V; et al. (2018). "An Outbreak of Rabbit Hemorrhagic Disease in Finland". Journal of Wildlife Diseases. 54 (4): 838–842. doi:10.7589/2017-11-286. PMID   29889007. S2CID   47009417.
  42. ↑ Cooke, BD (2014). Australia's War Against Rabbits. CSIRO Publishing. ISBN   9780643096127.
  43. ↑ Strive, T (2008). "Rabbit Calicivirus Disease (RCD)". Commonwealth Scientific and Industrial Research Organisation. Archived from the original (pdf) on April 15, 2014. Retrieved 14 April 2014.
  44. ↑ Adams, P (1 April 2017). "K5 rabbit virus an early success, researchers say". ABC News . Retrieved 2018-05-20.
  45. ↑ Munro, Robert K.; Williams, Richard T., eds. (1994). Rabbit Haemorrhagic Disease: Issues in Assessment for biological control. Canberra: Bureau of Resource Sciences. ISBN   9780644335126.
  46. ↑ Williams, D (26 May 2009). "Plan for 1080 drops in MacKenzie Basin". The Press. Retrieved 2009-06-14.
  47. ↑ "Welcome to 1080: The Facts". 1080facts.co.nz. Archived from the original on 2016-06-16. Retrieved 2013-12-05.
  48. ↑ "Rabbit calicivirus infection confirmed in Iowa rabbitry". www.avma.org. American Veterinary Medical Association. May 2000. Retrieved 22 June 2019.
  49. ↑ "Viral Hemorrhagic Disease of Rabbits_ Utah 8_28_01". www.aphis.usda.gov. Animal and Plant Health Inspection Service. Retrieved 22 June 2019.
  50. ↑ Campagnolo, ER; Ernst, MJ; Berniger, ML; et al. (October 2003). "Outbreak of rabbit hemorrhagic disease in domestic lagomorphs". Journal of the American Veterinary Medical Association. 223 (8): 1151–5. doi:10.2460/javma.2003.223.1151. PMID   14584745.
  51. ↑ "Rabbit Hemorrhagic Disease (Calicivirus) in the US" (PDF). AgLearn. Retrieved 22 June 2019.
  52. ↑ "Rabbit Hemorrhagic Disease_ Indiana". www.aphis.usda.gov. Animal and Plant Health Inspection Service. Retrieved 22 June 2019.
  53. ↑ "Rabbit haemorrhagic disease, United States of America (Jefferson County, Pennsylvania report)". OiE. World Organization for Animal Health. Retrieved 22 June 2019.
  54. ↑ "Rabbit hemorrhagic disease in British Columbia, Canada" (PDF). USDA. Retrieved 24 April 2020.
  55. ↑ "First report of Rabbit Hemorrhagic Disease Type 2 In US found in Ohio". Ohio Department of Agriculture. Retrieved 22 June 2019.
  56. ↑ McGann, C (19 June 2019). "Deadly rabbit disease confirmed on Orcas Island" (Press release). Olympia, WA: Washington State Department of Agriculture. Retrieved 6 December 2019.
  57. ↑ "Highly Contagious and Deadly Rabbit Disease Found in California for First Time". NBC Los Angeles. May 14, 2020. Retrieved 2020-05-16.
  58. 1 2 3 "Rabbit haemorrhagic disease, United States of America". OIE. Retrieved 8 May 2020.
  59. ↑ Staff, H. N. N. (22 June 2022). "State: Virus that's deadly to rabbits detected on Maui". hawaiinewsnow.com. Retrieved 2022-06-23.
  60. ↑ Gregg, DA; House, C; Berninger, M (1991). "Viral haemorrhagic disease of rabbits in Mexico : epidemiology and viral characterization". Revue Scientifique et Technique de l'OIE. 10 (2): 435–451. doi:10.20506/rst.10.2.556. ISSN   0253-1933. PMID   1760584.
  61. ↑ "Acuerdo por el que se declara el territorio de los Estados Unidos Mexicanos, libre de la enfermedad hemorrágica viral de los conejos". Diario Oficial de la Federación. Retrieved 8 May 2020.
  62. ↑ "Rabbit haemorrhagic disease, Mexico". OIE. Retrieved 8 May 2020.
  63. ↑ "WAHIS". wahis.woah.org. Retrieved 2024-02-27.
  64. ↑ Vargas, Bianca. "Detectan primer caso de fiebre hemorrágica viral". El Sol de Hidalgo | Noticias Locales, Policiacas, sobre México, Hidalgo y el Mundo (in Spanish). Retrieved 2024-02-27.
  65. ↑ Ortiz, Yulissa. "Advierten sobre la enfermedad hemorrágica viral del conejo en Tulancingo". El Sol de Tulancingo | Noticias Locales, Policiacas, sobre México, Hidalgo y el Mundo (in Spanish). Retrieved 2024-02-27.
  66. ↑ Vargas, Gustavo. "Inmunizan a más de 390 mil conejos en Tepeapulco". El Sol de Hidalgo | Noticias Locales, Policiacas, sobre México, Hidalgo y el Mundo (in Spanish). Retrieved 2024-02-27.
  67. ↑ "Story Map Journal". dj.senasica.gob.mx. Retrieved 2024-02-27.
  68. ↑ Farnós, O; Fernández, E; Chiong, M; et al. (2009). "Virus-like particles of the Rabbit Hemorrhagic Disease Virus obtained in yeast are able to induce protective immunity against classical strains and a viral subtype circulating in Cuba". Biotecnología Aplicada. 26 (3).
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.