Rage syndrome | |
---|---|
Other names | A22, episodic dyscontrol, stimulus-responsive psychomotor epilepsy, Mental lapse aggression syndrome |
The Malinois was the first breed to have a specific genetic polymorphism linked to rage syndrome. | |
Specialty | Neurology |
Symptoms | |
Complications | Behavioral euthanasia |
Usual onset | 1–3 years old |
Duration | Lifelong |
Causes | Unknown |
Risk factors | PolyA(22) (in Malinois), DAT-VNTR (in Malinois), likely other genetic factors, breed, other seizures |
Diagnostic method | EEG, with complete exclusion of other medical conditions via thorough medical testing |
Differential diagnosis | Any untreated illness (Pathophysiological aggression) or behavioral condition |
Prevention | Selective breeding, Health testing (PolyA(22) test, in Malinois) |
Management | Anticonvulsants, muzzling, barrier use, lifestyle changes |
Medication | Antiepileptic drugs (Phenobarbital) |
Prognosis | Generally poor |
Rage syndrome is a rare seizure disorder in dogs, characterized by explosive aggression. [1] [2] [3]
It is frequently confused with idiopathic aggression, a term for aggression with no identifiable cause. Rage syndrome is most often a misdiagnosis of dogs with an unrelated, but more common, form of aggression. Although the scientific evidence is limited, it is thought to be genetic in origin, and is heritable. [4] It is treated with antiepileptics. [5]
Rage syndrome has been known by a variety of names since it was discovered. [1] [3] Rage syndrome is a colloquial term most often preferred by dog trainers, handlers, and some behavior consultants. Alternative names used by researchers, veterinary scientists, and behavior specialists include mental lapse syndrome (MLS) and episodic dyscontrol. [1]
Rage syndrome is also sometimes termed a form of epilepsy, particularly limbic epilepsy. [6] [7] The term limbic epilepsy for rage syndrome has been used synonymously with the terms psychomotor epilepsy, automatic epilepsy, rhinencephalic epilepsy, behavioral epilepsy, temporal lobe epilepsy, and autonomic epilepsy. [6] [7] [8] [9] [10] In addition, depending on the professional's discretion the word "seizure" may be substituted for "epilepsy" in a given study or resource. [7] Edward B. Breitschwerdt, a researcher and veterinarian, wrote that this "profusion of synonyms makes it difficult to clearly ascertain the results of either clinical or research investigations of limbic epilepsy in the dog". [6]
Rage syndrome is frequently confused with idiopathic aggression, a term for aggression with no identifiable cause, due to sharing a name with it in its earliest studies before being identified as a discrete condition. In early research Rage syndrome is sometimes referred to as sudden-onset idiopathic aggression (SOIA) to distinguish it from idiopathic disease, and later as sudden-onset aggression (SOA).
Rage syndrome has no medical connection to rabies, for which its name is sometimes mistaken (from the Latin noun rabiēs, meaning "rage").
Aggression in rage syndrome is characterized by its severity and often fatal to dogs, animals, or people it is targeted towards. [1] Episodes may cause life-threatening injuries and result in disability or disfigurement. [1]
Dogs with rage syndrome typically have their first rage episode during adolescence, between 1 and 3 years old, similar to dogs with idiopathic epilepsy. [1]
Interictal EEGs under general anesthesia typically show low-voltage rapid discharges characteristic of focal seizures. [1] [11] [12] Seizure foci are in the temporal lobe, most often the left temporal lobe. [1] [13]
Prognosis for treatment of rage syndrome is guarded. [1] It is treated with antiepileptics. [5]
The English Springer Spaniel is the origin of the term "Springer Rage" frequently used in the 1970s and 1980s.
English Springer Spaniels were the breed most often referred to dog behavior consultants for aggression in the 1980s. [2] [14] [15]
Pat Miller wrote in Beware of the Dog: Positive Solutions for Aggressive Behavior in Dogs in 2017: "[Rage syndrome] captured the imagination of the dog world, and soon every dog with episodes of sudden, explosive aggression was tagged with the unfortunate "rage syndrome" label, especially if it was a Spaniel of any type." [16]
Bull terriers have also been used in research studies on breed-specific hereditary focal seizures, sometimes including aggressive symptoms. [17]
Rage syndrome is diagnosed by EEG. [1] [4] [13]
Thyroid function is tested during typical diagnostic workups as thyroid conditions, most commonly hypo- and hyperthyroidism, have been suggested to cause pathophysiological aggression that may present similarly to Rage syndrome. [1] [18]
In 2002 a 4-month-old tigress was reported with symptoms analogous to rage syndrome. [13] The tigress had episodes between 30 seconds and a minute long of explosive self-directed aggression and self-mutilation, in addition to occasional generalized tonic-clonic seizures and both focal and generalized neurologic symptoms such as episodes of continuously walking in circles to the right and epileptic blindness. Her EEG showed left frontal-temporal epileptiform activity, confirming a diagnosis of complex partial seizures. Cerebrospinal fluid testing, hematologic testing, serotologic testing, and serum biochemistry profile were all normal aside from faintly elevated CSF proteins. The tigress was the result of a consanguineous breeding and one of her littermates was diagnosed with generalized seizures. She was successfully treated with phenobarbital (2.5 mg/kg by mouth twice a day, bringing her within the therapeutic range at a blood concentration of 24 mg/dl). [13]
In 1980 it was suggested that electroconvulsive therapy, prefrontal lobotomy, and partial cerebral hypoxia (hypoxic-anoxic brain injury) be used to treat rage syndrome. [1] A 1974 study on prefrontal lobotomy of aggressive dogs found that 50% of lobotomized dogs died of complications. [19] Surviving dogs developed seizures, fecal and urinary incontinence, confusion, memory loss, seromas, emotional dysregulation, focal neurologic symptoms, weakness, and weight loss. [19] 40% of surviving dogs did not have a reduction in existing aggression, and some dogs' aggression worsened after the procedure. [19] The treatments were described as heroic measures which caused further damage to the dogs' health but were undertaken as a last resort to preserve the lives of the dogs. Multiple dogs which did not die from the procedure itself were euthanized anyway. [19]
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. An epileptic seizure is the clinical manifestation of an abnormal, excessive, and synchronized electrical discharge in the neurons. The occurrence of two or more unprovoked seizures defines epilepsy. The occurrence of just one seizure may warrant the definition in a more clinical usage where recurrence may be able to be prejudged. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical activity in the brain. These episodes can result in physical injuries, either directly, such as broken bones, or through causing accidents. In epilepsy, seizures tend to recur and may have no detectable underlying cause. Isolated seizures that are provoked by a specific cause such as poisoning are not deemed to represent epilepsy. People with epilepsy may be treated differently in various areas of the world and experience varying degrees of social stigma due to the alarming nature of their symptoms.
A coonhound, colloquially a coon dog, is a type of scenthound, a member of the hound group. They are an American type of hunting dog developed for the hunting of raccoons and also for feral pigs, bobcats, cougars, and bears. There are six distinct breeds of coonhound.
Gastric dilatation volvulus (GDV), also known as gastric dilation, twisted stomach, or gastric torsion, is a medical condition that affects dogs and rarely cats and guinea pigs, in which the stomach becomes overstretched and rotated by excessive gas content. The condition also involves compression of the diaphragm and caudal vena cavae. The word bloat is often used as a general term to mean gas distension without stomach torsion, or to refer to GDV.
Absence seizures are one of several kinds of generalized seizures. In the past, absence epilepsy was referred to as "pyknolepsy," a term derived from the Greek word "pyknos," signifying "extremely frequent" or "grouped". These seizures are sometimes referred to as petit mal seizures ; however, usage of this terminology is no longer recommended. Absence seizures are characterized by a brief loss and return of consciousness, generally not followed by a period of lethargy. Absence seizures are most common in children. They affect both sides of the brain.
Neutering, from the Latin neuter, is the removal of a non-human animal's reproductive organ, either all of it or a considerably large part. The male-specific term is castration, while spaying is usually reserved for female animals. Colloquially, both terms are often referred to as fixing. In male horses, castrating is referred to as gelding. An animal that has not been neutered is sometimes referred to as entire or intact.
The English Cocker Spaniel is a breed of gun dog. It is noteworthy for producing one of the most varied numbers of pups in a litter among all dog breeds. The English Cocker Spaniel is an active, good-natured, sporting dog standing well up at the withers and compactly built. There are "field" or "working" cockers and "house" cockers. It is one of several varieties of spaniel and is the foundation of its American cousin, the American Cocker Spaniel. The English Cocker is closer to the working-dog form of the Field Spaniel and the English Springer Spaniel. English Cocker Spaniels are also known as the "Merry Spaniel" due to their constantly wagging tail.
The Brittany Spaniel or Breton Spaniel is a French breed of gun dog of spaniel type, bred primarily for bird hunting.
The Old English Sheepdog is a large breed of dog that emerged in England from early types of herding dog. Other names for the breed include Shepherd's Dog and bob-tailed sheep-dog. The nickname Bob-tail originates from how dogs of the breed traditionally had their tails docked. Old English Sheepdogs can grow very long coats with fur covering the face and eyes and do not shed unless brushed.
Dog aggression expressed by dogs is considered to be normal behaviour and various types of aggression are influenced by a dog's environment and genetic predisposition. Dogs commonly display possessive aggression when defending resources or themselves.
Intermittent explosive disorder (IED) is a mental and behavioral disorder characterized by explosive outbursts of anger and/or violence, often to the point of rage, that are disproportionate to the situation at hand. Impulsive aggression is not premeditated, and is defined by a disproportionate reaction to any provocation, real or perceived. Some individuals have reported affective changes prior to an outburst, such as tension, mood changes, and energy changes.
The Dobermann is a German breed of medium-large working dog of pinscher type. It was originally bred in Thuringia in about 1890 by Louis Dobermann, a tax collector. It has a long muzzle and – ideally – an even and graceful gait. The ears were traditionally cropped and the tail docked, practices which are now illegal in many countries.
The health of dogs is a well studied area in veterinary medicine.
Epilepsy in animals is a group of neurological disorders characterized by seizures, caused by uncontrolled, abnormal bursts of electrical activity in the brain. They can start and stop very abruptly and last any amount of time from a few seconds to a few minutes. Canine epilepsy is often genetic but epilepsy in cats and other pets is rarer, likely because there is no hereditary component to epilepsy in these animals.
Dog behavior is the internally coordinated responses of individuals or groups of domestic dogs to internal and external stimuli. It has been shaped by millennia of contact with humans and their lifestyles. As a result of this physical and social evolution, dogs have acquired the ability to understand and communicate with humans. Behavioral scientists have uncovered a wide range of social-cognitive abilities in domestic dogs.
Separation anxiety in dogs describes a condition in which a dog exhibits distress and behavior problems when separated from its handler. Separation anxiety typically manifests within minutes of departure of the handler. It is not fully understood why some dogs suffer from separation anxiety and others do not. The diagnosis process often leads to a misdiagnosis as it is difficult to differentiate from other medical and behavioral problems. The behavior may be secondary to an underlying medical condition. With chronic stress, impairments to physiological health can manifest. Increased stress in the dog alters hormone levels, thus decreasing natural immunity to various health problems. Separation anxiety can be treated with systematic desensitization and, if necessary, medication. Ignoring or punishing the dog, leaving them to "cry it out" does not solve separation anxiety and can damage the mental health of dogs.
Dog appeasing pheromone (DAP), sometimes known as apasine, is a mixture of esters of fatty acids released by the sebaceous glands in the inter-mammary sulcus of lactating female dogs. It is secreted from between three and four days after parturition and two to five days after weaning. DAP is believed to be detected by the vomeronasal organ and has an appeasing effect on both adults and pups, and assists in establishing a bond with the mother.
Tail chasing is a behaviour exhibited in dogs that is characterized by spinning in tight circles in either direction, and can be slow and focused on the tail or fast and unfocused. It is a compulsion similar to those seen in humans suffering from OCD and it can be quite disruptive to the lives of the dogs themselves, as well as their owners. Some causes have been suggested, including genetic factors, and environmental factors that vary depending on the individual dog. Furthermore, treatment options include drugs that decrease the frequency of tail chasing by targeting the underlying mechanisms, and behavioural changes regulated by the dog's owners.
Fly biting refers to a type of dog behavior: episodes of intentional focused biting at the air, as if the dog is biting at imaginary flies. Cavalier King Charles Spaniels appear to be predisposed to fly catching syndrome, though it has been documented in many different breeds and mixes. Age of onset is varied.
Immune-mediated thrombocytopaenia (IMT) is a disease common in dogs and rare in cats. The disease is characterised by a low platelet count caused by destruction of the platelets from the immune system. IMT is the most common cause of thrombocytopaenia in dogs.