Ribitol 2-dehydrogenase

ribitol 2-dehydrogenase
Identifiers
EC no.	1.1.1.56
CAS no.	9014-23-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a ribitol 2-dehydrogenase (EC 1.1.1.56) is an enzyme that catalyzes the chemical reaction

Ribitol

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

D-Ribulose

+ NADH

 

The two substrates of this enzyme are ribitol and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are D-ribulose, reduced NADH, and a proton. ^{[1] [2] [3] [4]}

This enzyme participates in pentose and glucuronate interconversions.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is ribitol:NAD⁺ 2-oxidoreductase. Other names in common use include adonitol dehydrogenase, ribitol dehydrogenase A (wild type), ribitol dehydrogenase B (mutant enzyme with different properties), and ribitol dehydrogenase D (mutant enzyme with different properties).

References

1. Enzyme 1.1.1.56 at KEGG Pathway Database.
2. Hollmann S, Touster O (Mar 1957). "The L-xylulose-xylitol enzyme and other polyol dehydrogenases of guinea pig liver mitochondria". The Journal of Biological Chemistry. 225 (1): 87–102. doi: 10.1016/S0021-9258(18)64912-9 . PMID   13416220.
3. Nordlie RC, Fromm HJ (Oct 1959). "Ribitol dehydrogenase. II. Studies on the reaction mechanism". The Journal of Biological Chemistry. 234 (10): 2523–31. doi: 10.1016/S0021-9258(18)69732-7 . PMID   14427582.
4. Wood WA, McDonough MJ, Jacobs LB (Aug 1961). "Ribitol and D-arabitol utilization by Aerobacter aerogenes". The Journal of Biological Chemistry. 236 (8): 2190–5. doi: 10.1016/S0021-9258(18)64054-2 . PMID   13786517.