Ribonucleoside-triphosphate reductase

Ribonucleoside-triphosphate reductase
Ribonucleoside-triphosphate reductase dimer, Thermotoga maritima
Identifiers
EC no.	1.17.4.2
CAS no.	9068-66-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Ribonucleoside-triphosphate reductase (EC 1.17.4.2, ribonucleotide reductase , 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase. ^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H₂O ${\displaystyle \rightleftharpoons }$ ribonucleoside triphosphate + thioredoxin

Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.

References

1. Blakley RL (May 1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii". The Journal of Biological Chemistry. 240 (5): 2173–80. doi: 10.1016/S0021-9258(18)97442-9 . PMID   14299643.
2. Goulian M, Beck WS (September 1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii". The Journal of Biological Chemistry. 241 (18): 4233–42. doi: 10.1016/S0021-9258(18)99774-7 . PMID   5924645.
3. Lammers, M.; Follmann, H. (1983). "The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation". Struct. Bonding. Structure and Bonding. 54: 27–91. doi:10.1007/bfb0111318. ISBN   978-3-540-12542-6.

External links

• Ribonucleoside-triphosphate+reductase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)