Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene. [5] [6] [7]
Beta-1-syntrophin is a protein that in humans is encoded by the SNTB1 gene. [5] [6] [7]
Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally related genes. [7]
SNTB1 has been shown to interact with Dystrophin. [8]
Dystrophin is a rod-shaped cytoplasmic protein, and a vital part of a protein complex that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane. This complex is variously known as the costamere or the dystrophin-associated protein complex (DAPC). Many muscle proteins, such as α-dystrobrevin, syncoilin, synemin, sarcoglycan, dystroglycan, and sarcospan, colocalize with dystrophin at the costamere.
Utrophin is a protein that in humans is encoded by the UTRN gene.
Dystrobrevin is a protein that binds to dystrophin in the costamere of skeletal muscle cells. In humans, there are at least two isoforms of dystrobrevin, α-dystrobrevin and β-dystrobrevin.
Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2, calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2.
Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.
Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.
Alpha-1-syntrophin is a protein that in humans is encoded by the SNTA1 gene. Alpha-1 syntrophin is a signal transducing adaptor protein and serves as a scaffold for various signaling molecules. Alpha-1 syntrophin contains a PDZ domain, two Pleckstrin homology domain and a 'syntrophin unique' domain.
Beta-sarcoglycan is a protein that in humans is encoded by the SGCB gene.
Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.
Delta-sarcoglycan is a protein that in humans is encoded by the SGCD gene.
Beta-2-syntrophin is a protein that in humans is encoded by the SNTB2 gene.
InaD-like protein is a protein that in humans is encoded by the PATJ gene.
Gamma-sarcoglycan is a protein that in humans is encoded by the SGCG gene. The α to δ-sarcoglycans are expressed predominantly (β) or exclusively in striated muscle. A mutation in any of the sarcoglycan genes may lead to a secondary deficiency of the other sarcoglycan proteins, presumably due to destabilisation of the sarcoglycan complex. The disease-causing mutations in the α to δ genes cause disruptions within the dystrophin-associated protein (DAP) complex in the muscle cell membrane. The transmembrane components of the DAP complex link the cytoskeleton to the extracellular matrix in adult muscle fibres, and are essential for the preservation of the integrity of the muscle cell membrane.
Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.
Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.
Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.
Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.
Myozenin-1 is a protein that in humans is encoded by the MYOZ1 gene.
Dystrobrevin alpha is a protein that in humans is encoded by the DTNA gene.
Beta dystrobrevin also known as DTNB is a protein which in humans is encoded by the DTNB gene.
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