SNTG1

SNTG1
Identifiers
Aliases	SNTG1 , G1SYN, SYN4, syntrophin gamma 1
External IDs	OMIM: 608714 MGI: 1918346 HomoloGene: 56834 GeneCards: SNTG1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	50,796,692 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	9,299,878 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; nucleus accumbens; ; prefrontal cortex; ; caudate nucleus; ; superior frontal gyrus; ; putamen; ; postcentral gyrus;
	Top expressed in
	spermatid; ; superior frontal gyrus; ; facial motor nucleus; ; cerebellar cortex; ; hippocampus proper; ; seminiferous tubule; ; primary motor cortex; ; mesencephalon; ; anterior horn of spinal cord; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding ; protein C-terminus binding ; structural molecule activity ;
Cellular component	cytoplasm ; ruffle membrane ; syntrophin complex ; cytoskeleton ; nucleus ; dystrophin-associated glycoprotein complex ;
Biological process	cell communication ;
	Sources:Amigo / QuickGO
Orthologs
	54212
	71096
	ENSG00000147481
	ENSMUSG00000025909
	Q9NSN8
	Q925E1
NM_001287813 ; NM_001287814 ; NM_018967 ; NM_001321773 ; NM_001321775 ;
	NM_001321776 ; NM_001321777 ; NM_001321778
	NM_001290390 ; NM_001290392 ; NM_001290393 ; NM_027671
NP_001274742 ; NP_001274743 ; NP_001308702 ; NP_001308704 ; NP_001308705 ;
	NP_001308706 ; NP_001308707 ; NP_061840 ; NP_001274742.1 ; NP_061840.1 ; NP_001308702.1
	NP_001277319 ; NP_001277321 ; NP_001277322 ; NP_081947
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.^[5]^[6]

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Transcript variants for this gene have been described, but their full-length nature has not been determined.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000147481 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025909 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Piluso G, Mirabella M, Ricci E, Belsito A, Abbondanza C, Servidei S, Puca AA, Tonali P, Puca GA, Nigro V (Jun 2000). "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells". J Biol Chem. 275 (21): 15851–60. doi: 10.1074/jbc.M000439200 . PMID 10747910.
1 2 "Entrez Gene: SNTG1 syntrophin, gamma 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Hogan A, Shepherd L, Chabot J, et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. Biol. Chem. 276 (28): 26526–33. doi: 10.1074/jbc.M104156200 . PMID 11352924.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Widberg CH, Bryant NJ, Girotti M, et al. (2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. 278 (37): 35093–101. doi: 10.1074/jbc.M304261200 . PMID 12832401.
Buxton P, Zhang XM, Walsh B, et al. (2004). "Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells". Biochem. J. 375 (Pt 2): 433–40. doi:10.1042/BJ20030427. PMC 1223698 . PMID 12877659.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Chen Z, Hague C, Hall RA, Minneman KP (2006). "Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction". J. Biol. Chem. 281 (18): 12414–20. doi: 10.1074/jbc.M508651200 . PMID 16533813.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000147481 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025909 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10747910-5] Piluso G, Mirabella M, Ricci E, Belsito A, Abbondanza C, Servidei S, Puca AA, Tonali P, Puca GA, Nigro V (Jun 2000). "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells". J Biol Chem. 275 (21): 15851–60. doi: 10.1074/jbc.M000439200 . PMID 10747910.

[entrez-6] 1 2 "Entrez Gene: SNTG1 syntrophin, gamma 1".

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SNTG1

Related Research Articles

References

Further reading