Serine 3-dehydrogenase

serine 3-dehydrogenase
Identifiers
EC no.	1.1.1.276
CAS no.	9038-55-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, serine 3-dehydrogenase (EC 1.1.1.276) is an enzyme that catalyzes the chemical reaction

L-serine

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

L-3-oxo-alanine

+ NADH

 

The two substrates of this enzyme are L-serine and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are L-3-oxo-alanine, reduced NADPH, and a proton. ^{[1] [2] [3]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-serine:NADP⁺ 3-oxidoreductase.

References

1. Enzyme 1.1.1.276 at KEGG Pathway Database.
2. Fujisawa H, Nagata S, Chowdhury EK, Matsumoto M, Misono H (2002). "Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens". Biosci. Biotechnol. Biochem. 66 (5): 1137–9. doi: 10.1271/bbb.66.1137 . PMID   12092831.
3. Chowdhury EK, Higuchi K, Nagata S, Misono H (1997). "A novel NADP(+)-dependent serine dehydrogenase from Agrobacterium tumefaciens". Biosci. Biotechnol. Biochem. 61 (1): 152–7. doi: 10.1271/bbb.61.152 . PMID   9028042.