Tetrahydroxynaphthalene reductase

tetrahydroxynaphthalene reductase
Identifiers
EC no.	1.1.1.252
CAS no.	153702-05-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, tetrahydroxynaphthalene reductase (EC 1.1.1.252) is an enzyme that catalyzes the chemical reaction

scytalone

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

naphthalene-1,3,6,8-tetrol

+ NADPH

 

The two substrates of this enzyme are scytalone and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are naphthalene-1,3,6,8-tetrol, reduced NADPH, and a proton. ^{[1] [2] [3] [4]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is scytalone:NADP⁺ Delta5-oxidoreductase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DOH, 1G0N, and 1G0O.

References

1. Enzyme 1.1.1.252 at KEGG Pathway Database.
2. Wheeler MH; Greenblatt GA (1988). "The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease". Exp. Mycol. 12 (2): 151–160. doi:10.1016/0147-5975(88)90004-7.
3. Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M (1994). "Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing". Eur. J. Biochem. 219 (3): 985–92. doi: 10.1111/j.1432-1033.1994.tb18581.x . PMID   8112349.
4. Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB (1997). "Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism". Biochemistry. 36 (7): 1852–60. doi:10.1021/bi962355u. PMID   9048570.