Thebaine 6-O-demethylase

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Thebaine 6-O-demethylase
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EC no. 1.14.11.31
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Thebaine 6-O-demethylase (EC 1.14.11.31, T6ODM) is an enzyme with systematic name thebaine,2-oxoglutarate:oxygen oxidoreductase (6-O-demethylating). [1] This enzyme catalyses the following chemical reaction

thebaine + 2-oxoglutarate + O2 neopinone + formaldehyde + succinate + CO2

Thebaine 6-O-demethylase contains Fe2+.

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Christopher Joseph Schofield is a Professor of Chemistry at the University of Oxford and a Fellow of the Royal Society. Chris Schofield is a professor of organic chemistry at the University of Oxford, Department of Chemistry and a Fellow of Hertford College. Schofield studied functional, structural and mechanistic understanding of enzymes that employ oxygen and 2-oxoglutarate as a co-substrate. His work has opened up new possibilities in antibiotic research, oxygen sensing, and gene regulation.

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References

  1. ↑ Hagel JM, Facchini PJ (April 2010). "Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy". Nature Chemical Biology. 6 (4): 273–5. doi:10.1038/nchembio.317. PMID   20228795.
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