Thrombopoietin mimetics

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Thrombopoietin mimetics are drugs that considerably increase platelet production by stimulating the receptor for the hormone thrombopoietin; Romiplastin and Eltrombopag are examples. [1] Thrombopoietin mimetics are a type of thrombopoietic agents. There has been a development of a registry of pregnant patients that were treated with these drugs. [2]

Drug chemical substance having an effect on the body

A drug is any substance that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a physiological change in the body.

Platelet component of blood

Platelets, also called thrombocytes, are a component of blood whose function is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot. Platelets have no cell nucleus: they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow, and then enter the circulation. Circulating unactivated platelets are biconvex discoid (lens-shaped) structures, 2–3 µm in greatest diameter. Platelets are found only in mammals, whereas in other animals thrombocytes circulate as intact mononuclear cells.

Thrombopoietin protein-coding gene in the species Homo sapiens

Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene.

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Blood transfusion generally the process of receiving blood or blood products into ones circulation intravenously

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Thrombocytopenia A blood platelet disease characterized by a low platelet count in the blood.

Thrombocytopenia is a condition characterized by abnormally low levels of thrombocytes, also known as platelets, in the blood.

Megakaryocyte

A megakaryocyte is a large bone marrow cell with a lobated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting. Megakaryocytes usually account for 1 out of 10,000 bone marrow cells in normal people, but can increase in number nearly 10-fold during the course of certain diseases. Owing to variations in combining forms and spelling, synonyms include megalokaryocyte and megacaryocyte.

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Transfusion-related acute lung injury

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Eptifibatide chemical compound

Eptifibatide, is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class. Eptifibatide is a cyclic heptapeptide derived from a protein found in the venom of the southeastern pygmy rattlesnake. It belongs to the class of the arginin-glycin-aspartat-mimetics and reversibly binds to platelets. Eptifibatide has a short half-life. The drug is the third inhibitor of GPIIb/IIIa that has found broad acceptance after the specific antibody abciximab and the non-peptide tirofiban entered the global market.

Mangafodipir chemical compound

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Thrombopoietic agents are drugs that induce the growth and maturation of megakaryocytes. Some of them are currently in clinical use: romiplostim, eltrombopag, oprelvekin and thrombopoietin. Several others are under clinical investigation such as lusutrombopag and avatrombopag.

Eltrombopag chemical compound

Eltrombopag is a medication that has been developed for certain conditions that lead to thrombocytopenia. It is a small molecule agonist of the c-mpl (TpoR) receptor, which is the physiological target of the hormone thrombopoietin. Eltrombopag was discovered as a result of research collaboration between GlaxoSmithKline and Ligand Pharmaceuticals. Designated an orphan drug in the United States and European Union, it is being manufactured and marketed by Novartis under the trade name Promacta in the USA and is marketed as Revolade in the EU. Novartis acquired the drug as a part of its asset swap deal with GlaxoSmithKline.

Thrombopoietin receptor protein-coding gene in the species Homo sapiens

The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 is a protein that in humans is encoded by the MPL oncogene.

Romiplostim pharmaceutical drug

Romiplostim is a fusion protein analog of thrombopoietin, a hormone that regulates platelet production.

Congenital amegakaryocytic thrombocytopenia thrombocytopenia characterized by a severe reduction in megakaryocyte and platelet numbers that has material basis in homozygous or compound heterozygous mutation in the MPL gene on chromosome 1p34

Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare inherited disorder.

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JWH-193 chemical compound

JWH-193 is a drug from the aminoalkylindole family which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 receptor of 6nM, binding around seven times more tightly than the parent compound JWH-200, though with closer to twice the potency of JWH-200 in activity tests. A structural isomer of JWH-193 with the methyl group on the indole ring instead of the naphthoyl ring, was also found to be of similarly increased potency over JWH-200.

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A protein mimetic is a molecule such as a peptide, a modified peptide or any other molecule that biologically mimics the action or activity of some other protein. Protein mimetics are commonly used in drug design and discovery.

Tavilermide chemical compound

Tavilermide (INN) is a selective, cyclic peptide partial agonist of TrkA. It is under development by Mimetogen Pharmaceuticals as an ophthalmic solution for the treatment of dry eyes, and is in phase III clinical trials for this indication. Tavilermide is currently being evaluated in two multi-center phase III clinical studies in the United States for the treatment of dry eye disease. Tavilermide is also in phase I clinical trials for the treatment of glaucoma; studies are ongoing.

References

  1. http://www.transfusionguidelines.org.uk/transfusion-handbook/6-alternatives-and-adjuncts-to-blood-transfusion/6-3-thrombopoietin-mimetics
  2. Ronald Hoffman; Edward J. Benz, Jr.; Leslie E. Silberstein; Helen Heslop; Jeffrey Weitz; John Anastasi (2013). Hematology: Basic Principles and Practice. Elsevier Health Sciences. p. 2135.