Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

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trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Identifiers
EC no. 1.3.1.20
CAS no. 37255-32-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) is an enzyme that catalyzes the chemical reaction

 
 
 
H+
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
 
H+
 
 

The two substrates of this enzyme are trans-1,2-dihydrocatechol and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are catechol, reduced NADPH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase. This enzyme is also called dihydrodiol dehydrogenase. This enzyme participates in metabolism of xenobiotics by cytochrome p450. [1]

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2HDJ, 2IPJ, 2O48, 2O4U, and 2POQ.

References

  1. 1 2 Enzyme 1.3.1.20 at KEGG Pathway Database.
  2. Ayengar PK, Hayaishi O, Nakajima M, Tomida I (1959). "Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol". Biochim. Biophys. Acta. 33 (1): 111–9. doi:10.1016/0006-3002(59)90504-9. PMID   13651190.