Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

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trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Identifiers
EC no. 1.3.1.20
CAS no. 37255-32-6
Databases
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BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
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PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, a trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) is an enzyme that catalyzes the chemical reaction

trans-1,2-dihydrobenzene-1,2-diol + NADP+ catechol + NADPH + H+

Thus, the two substrates of this enzyme are trans-1,2-dihydrobenzene-1,2-diol and NADP+, whereas its three products are catechol, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase. This enzyme is also called dihydrodiol dehydrogenase. This enzyme participates in metabolism of xenobiotics by cytochrome p450.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2HDJ, 2IPJ, 2O48, 2O4U, and 2POQ.

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References