Uracil/thymine dehydrogenase

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Uracil/thymine dehydrogenase
Identifiers
EC no. 1.17.99.4
CAS no. 9029-00-9
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Uracil/thymine dehydrogenase (EC 1.17.99.4, uracil oxidase, uracil-thymine oxidase, uracil dehydrogenase ) is an enzyme with systematic name uracil:acceptor oxidoreductase. [1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

(1) uracil + H2O + acceptor barbiturate + reduced acceptor
(2) thymine + H2O + acceptor 5-methylbarbiturate + reduced acceptor

Uracil/thymine dehydrogenase forms part of the oxidative pyrimidine-degrading pathway in some microorganisms.

References

  1. Hayaishi O, Kornberg A (May 1952). "Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes". The Journal of Biological Chemistry. 197 (2): 717–32. doi: 10.1016/S0021-9258(18)55628-3 . PMID   12981104.
  2. Wang TP, Lampen JO (February 1952). "Metabolism of pyrimidines by a soil bacterium". The Journal of Biological Chemistry. 194 (2): 775–83. doi: 10.1016/S0021-9258(18)55832-4 . PMID   14927671.
  3. Wang TP, Lampen JO (February 1952). "Uracil oxidase and the isolation of barbituric acid from uracil oxidation". The Journal of Biological Chemistry. 194 (2): 785–91. doi: 10.1016/S0021-9258(18)55833-6 . PMID   14927672.
  4. Lara FJ (August 1952). "On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations". Journal of Bacteriology. 64 (2): 279–85. doi:10.1128/jb.64.2.279-285.1952. PMC   169350 . PMID   14955523.
  5. Soong CL, Ogawa J, Shimizu S (August 2001). "Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase". Biochemical and Biophysical Research Communications. 286 (1): 222–6. Bibcode:2001BBRC..286..222S. doi:10.1006/bbrc.2001.5356. PMID   11485332.