Ureidoglycolate dehydrogenase

ureidoglycolate dehydrogenase
Identifiers
EC no.	1.1.1.154
CAS no.	62213-62-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, ureidoglycolate dehydrogenase (EC 1.1.1.154) is an enzyme that catalyzes the chemical reaction

(-)-ureidoglycolic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

oxaluric acid

+ NADH

 

The two substrates of this enzyme are (-)-ureidoglycolic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are oxaluric acid, reduced NADH, and a proton. This enzyme can use the alternative cofactor, nicotinamide adenine dinucleotide phosphate. ^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-ureidoglycolate:NAD(P)⁺ oxidoreductase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WTJ and 1XRH.

References

1. Enzyme 1.1.1.154 at KEGG Pathway Database.
2. van der Drift C, van Helvoort PE, Vogels GD (1971). "S-ureidoglycolate dehydrogenase: purification and properties". Arch. Biochem. Biophys. 145 (2): 465–9. doi:10.1016/S0003-9861(71)80006-1. PMID   4399430.