CELSR2

CELSR2
Identifiers
Aliases	CELSR2 , CDHF10, EGFL2, Flamingo1, MEGF3, ADGRC2, cadherin EGF LAG seven-pass G-type receptor 2
External IDs	OMIM: 604265 MGI: 1858235 HomoloGene: 1078 GeneCards: CELSR2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 109,249,539 bp [1] End 109,275,751 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F3|3 47.02 cM Start 108,390,851 bp [2] End 108,415,552 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • G protein-coupled receptor activity • signal transducer activity • calcium ion binding • transmembrane signaling receptor activity Cellular component • integral component of membrane • plasma membrane • membrane • cytoplasm Biological process • homophilic cell adhesion via plasma membrane adhesion molecules • regulation of transcription, DNA-templated • cell surface receptor signaling pathway • multicellular organism development • regulation of cell-cell adhesion • Wnt signaling pathway, planar cell polarity pathway • G protein-coupled receptor signaling pathway • signal transduction • neural plate anterior/posterior regionalization • Wnt signaling pathway • cell adhesion • dendrite morphogenesis • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1952	53883
Ensembl	ENSG00000143126	ENSMUSG00000068740
UniProt	Q9HCU4	Q9R0M0
RefSeq (mRNA)	NM_001408	NM_001004177 NM_017392
RefSeq (protein)	NP_001399	NP_001004177 NP_059088
Location (UCSC)	Chr 1: 109.25 – 109.28 Mb	Chr 3: 108.39 – 108.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. ^[6]

See also

• Flamingo (protein)

References

1. GRCh38: Ensembl release 89: ENSG00000143126 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068740 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID   9693030.
6. "Entrez Gene: CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi: 10.1093/dnares/3.5.321 . PMID   9039502.
• Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi: 10.1016/S0092-8674(00)80789-8 . PMID   10380929. S2CID   6014717.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi: 10.1073/pnas.060027397 . PMC   16203 . PMID   10716726.
• Vincent JB, Skaug J, Scherer SW (2001). "The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1". DNA Res. 7 (3): 233–5. doi: 10.1093/dnares/7.3.233 . PMID   10907856.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.

External links

• Human CELSR2 genome location and CELSR2 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.