GPR68

GPR68
Identifiers
Aliases	GPR68 , GPR12A, OGR1, G protein-coupled receptor 68, AI2A6
External IDs	OMIM: 601404 MGI: 2441763 HomoloGene: 2603 GeneCards: GPR68
Gene location (Human)
Chr.	Chromosome 14 (human)
End	91,253,925 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	100,874,457 bp
RNA expression pattern
	Top expressed in
	cardia; ; pylorus; ; saphenous vein; ; pituitary gland; ; human penis; ; amniotic fluid; ; superior surface of tongue; ; anterior pituitary; ; nipple; ; blood;
	Top expressed in
	oocyte; ; secondary oocyte; ; cerebellar cortex; ; hippocampus proper; ; ciliary body; ; facial motor nucleus; ; blood; ; superior frontal gyrus; ; thymus; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity ; signal transducer activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	G protein-coupled receptor signaling pathway ; negative regulation of monocyte differentiation ; positive regulation of insulin secretion involved in cellular response to glucose stimulus ; cellular response to pH ; inflammatory response ; positive regulation of osteoclast development ; signal transduction ; positive regulation of insulin secretion ;
	Sources:Amigo / QuickGO
Orthologs
	8111
	238377
	ENSG00000119714
	ENSMUSG00000047415
	Q15743
	Q8BFQ3
	NM_001177676 ; NM_003485 ; NM_001348437
	NM_001177673 ; NM_001177674 ; NM_175493
	NP_001171147 ; NP_003476 ; NP_001335366
	NP_001171144 ; NP_001171145 ; NP_780702 ; NP_001390243
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 05, 2024

Ovarian cancer G-protein coupled receptor 1 is a protein that in humans is encoded by the GPR68 gene.^[5]^[6]

Related Research Articles

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB family of signaling molecules.

G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene.

G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.

G-protein coupled receptor 39 is a protein that in humans is encoded by the GPR39 gene.

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.

Mas-related G-protein coupled receptor member E is a protein that in humans is encoded by the MRGPRE gene.

Integral membrane protein GPR155, also known as G protein-coupled receptor 155, is a protein that in humans is encoded by the GPR155 gene. Mutations in this gene may be associated with autism.

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

G protein-coupled receptor 148, also known as GPR148, is a human orphan receptor from GPCR superfamily. It is expressed primarily in nervous system and testis. Is may be implicated in prostate cancer.

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein that in humans is encoded by the LPAR3 gene. LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.

Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene.

Olfactory receptor 10J1 is a protein that in humans is encoded by the OR10J1 gene.

Olfactory receptor 2L2 is a protein that in humans is encoded by the OR2L2 gene.

Olfactory receptor 7A5 is a protein that in humans is encoded by the OR7A5 gene.

Olfactory receptor 2A4 is a protein that in humans is encoded by the OR2A4 gene.

NPW is a gene that in humans encodes Neuropeptide W protein.

Low-density lipoprotein receptor-related protein 10 is a protein that in humans is encoded by the LRP10 gene.

<span class="mw-page-title-main">Proton-sensing G protein-coupled receptors</span>

Proton-sensing G protein-coupled receptors are transmembrane receptors which sense acidic pH and include GPR132 (G2A), GPR4, GPR68 (OGR1) and GPR65 (TDAG8). These G protein-coupled receptors are activated when extracellular pH falls into the range of 6.4-6.8. The functional role of the low pH sensitivity of the proton-sensing G protein-coupled receptors is being studied in several tissues where cells respond to conditions of low pH including bone and inflamed tissues. The four known proton-sensing G protein-coupled receptors are Class A receptors in subfamily A15.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000119714 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047415 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Xu Y, Casey G (Sep 1996). "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14". Genomics. 35 (2): 397–402. doi:10.1006/geno.1996.0377. PMID 8661159.
↑ "Entrez Gene: GPR68 G protein-coupled receptor 68".

Xu Y (2002). "Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction". Biochim. Biophys. Acta. 1582 (1–3): 81–8. doi:10.1016/S1388-1981(02)00140-3. PMID 12069813.
An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue". FEBS Lett. 375 (1–2): 121–4. doi: 10.1016/0014-5793(95)01196-L . PMID 7498459. S2CID 9845527.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ludwig MG, Vanek M, Guerini D, et al. (2003). "Proton-sensing G-protein-coupled receptors". Nature. 425 (6953): 93–8. Bibcode:2003Natur.425...93L. doi:10.1038/nature01905. PMID 12955148. S2CID 4395698.
Bektas M, Barak LS, Jolly PS, et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry. 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632–7. Bibcode:2005PNAS..102.1632R. doi: 10.1073/pnas.0409415102 . PMC 545089 . PMID 15665078.
Tomura H, Wang JQ, Komachi M, et al. (2005). "Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells". J. Biol. Chem. 280 (41): 34458–64. doi: 10.1074/jbc.M505287200 . PMID 16087674.
Singh LS, Berk M, Oates R, et al. (2007). "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer". J. Natl. Cancer Inst. 99 (17): 1313–27. doi: 10.1093/jnci/djm107 . hdl: 10536/DRO/DU:30094039 . PMID 17728215.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000119714 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047415 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8661159-5] Xu Y, Casey G (Sep 1996). "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14". Genomics. 35 (2): 397–402. doi:10.1006/geno.1996.0377. PMID 8661159.

[entrez-6] "Entrez Gene: GPR68 G protein-coupled receptor 68".

[1]

[2]

[3]

[4]

[5]

[6]

GPR68

Contents

See also

Related Research Articles

References

Further reading