TAS2R50

TAS2R50
Identifiers
Aliases	TAS2R50 , T2R50, T2R51, TAS2R51, taste 2 receptor member 50
External IDs	OMIM: 609627 HomoloGene: 88474 GeneCards: TAS2R50
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.2 Start 10,985,913 bp [1] End 10,986,912 bp [1]
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • bitter taste receptor activity Cellular component • cell membrane • membrane • integral component of membrane Biological process • detection of chemical stimulus involved in sensory perception of bitter taste • signal transduction • response to stimulus • sensory perception of taste • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	259296	n/a
Ensembl	ENSG00000212126 ENSG00000276167 ENSG00000273431	n/a
UniProt	P59544	n/a
RefSeq (mRNA)	NM_176890	n/a
RefSeq (protein)	NP_795371	n/a
Location (UCSC)	Chr 12: 10.99 – 10.99 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene. ^{[3] [4] [5] [6]}

Function

TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway. ^[4] See also TAS2R10. ^[6]

See also

• Taste receptor

References

1. ENSG00000276167, ENSG00000273431 GRCh38: Ensembl release 89: ENSG00000212126, ENSG00000276167, ENSG00000273431 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID   12379855. S2CID   20426192.
4. Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ (Feb 2003). "Identification and characterization of human taste receptor genes belonging to the TAS2R family". Cytogenet Genome Res. 98 (1): 45–53. doi:10.1159/000068546. PMID   12584440. S2CID   1542970.
5. Shiffman D, Ellis SG, Rowland CM, Malloy MJ, Luke MM, Iakoubova OA, Pullinger CR, Cassano J, Aouizerat BE, Fenwick RG, Reitz RE, Catanese JJ, Leong DU, Zellner C, Sninsky JJ, Topol EJ, Devlin JJ, Kane JP (Sep 2005). "Identification of Four Gene Variants Associated with Myocardial Infarction". Am J Hum Genet. 77 (4): 596–605. doi:10.1086/491674. PMC   1275608 . PMID   16175505.
6. "Entrez Gene: TAS2R50 taste receptor, type 2, member 50".

Further reading

• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi: 10.1074/jbc.R100054200 . PMID   11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID   12139982. S2CID   37807140.
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID   12581520. S2CID   718601.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi: 10.1093/molbev/msi027 . PMID   15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC   1449719 . PMID   15744053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.