VIPR1

Last updated
VIPR1
PDB 1of2 EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases VIPR1 , HVR1, II, PACAP-R-2, PACAP-R2, RDC1, V1RG, VAPC1, VIP-R-1, VIPR, VIRG, VPAC1, VPAC1R, VPCAP1R, vasoactive intestinal peptide receptor 1
External IDs OMIM: 192321 MGI: 109272 HomoloGene: 3399 GeneCards: VIPR1
Orthologs
SpeciesHumanMouse
Entrez

7433

22354

Ensembl

ENSG00000114812

ENSMUSG00000032528

UniProt

P32241

P97751

RefSeq (mRNA)

NM_001251882
NM_001251883
NM_001251884
NM_001251885
NM_004624

Contents

NM_011703

RefSeq (protein)

NP_001238811
NP_001238812
NP_001238813
NP_001238814
NP_004615

NP_035833

Location (UCSC) Chr 3: 42.49 – 42.54 Mb Chr 9: 121.47 – 121.5 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Vasoactive intestinal polypeptide receptor 1 also known as VPAC1, is a protein, that in humans is encoded by the VIPR1 gene. [5] VPAC1 is expressed in the brain (cerebral cortex, hippocampus, amygdala), lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus and testis. [6] [7] [8]

Function

VPAC1 is a receptor for vasoactive intestinal peptide (VIP), a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [5]

VIP acts in an autocrine fashion via VPAC11 to inhibit megakaryocyte proliferation and induce proplatelet formation. [9] [10]

Clinical significance

Patients with idiopathic achalasia show a significant difference in the distribution of SNPs affecting VIPR1. [11]

VIP and PACAP levels were decreased in anterior vaginal wall of stress urinary incontinence and pelvic organ prolapse patients, they may participate in the pathophysiology of these diseases. [12]

See also

Related Research Articles

Secretin Hormone involved in stomach, pancreas and liver secretions

Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the SCT gene.

Gastrin

Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.

Vasoactive intestinal peptide Hormone that affects blood pressure / heart rate

Vasoactive intestinal peptide, also known as vasoactive intestinal polypeptide or VIP, is a peptide hormone that is vasoactive in the intestine. VIP is a peptide of 28 amino acid residues that belongs to a glucagon/secretin superfamily, the ligand of class II G protein–coupled receptors. VIP is produced in many tissues of vertebrates including the gut, pancreas, and suprachiasmatic nuclei of the hypothalamus in the brain. VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gallbladder. In humans, the vasoactive intestinal peptide is encoded by the VIP gene.

Histamine H<sub>2</sub> receptor Mammalian protein found in Homo sapiens

H2 receptors are positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H2 receptor agonist.

There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2. These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family.

Pituitary adenylate cyclase-activating peptide

Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to vasoactive intestinal peptide receptor and to the PACAP receptor.

Secretin receptor

Human secretin receptor is a G protein-coupled receptor which binds secretin and is the leading member of the class B GPCR subfamily.

Glucagon-like peptide-2 receptor

Glucagon-like peptide-2 receptor (GLP-2R) is a protein that in human is encoded by the GLP2R gene located on chromosome 17.

ADCYAP1R1

Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC1, is a protein that in humans is encoded by the ADCYAP1R1 gene. This receptor binds pituitary adenylate cyclase activating peptide.

CMKLR1

Chemokine like receptor 1 also known as ChemR23 is a protein that in humans is encoded by the CMKLR1 gene. Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin and the omega-3 fatty acid eicosapentaenoic acid-derived specialized pro-resolving molecule, resolvin E1. The murine receptor that shares almost 80% homology with the human receptor, is called Dez.

Galanin receptor 1

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene.

Endothelin A receptor Protein-coding gene in the species Homo sapiens

Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor.

Melanocortin 5 receptor

Melanocortin 5 receptor is a protein that in humans is encoded by the MC5R gene. It is located on the chromosome 18 in the human genome. When the melanocortin 5 receptor was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.

P2RY6

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.

Somatostatin receptor 4

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.

VIPR2 Protein-coding gene in the species Homo sapiens

Vasoactive intestinal peptide receptor 2 also known as VPAC2, is a G-protein coupled receptor that in humans is encoded by the VIPR2 gene.

LPAR2 Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene. LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

ACKR3 Mammalian protein found in Homo sapiens

Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene.

FKBP1B

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.

GPR182

GPR182 is a human gene which is an orphan G-protein coupled receptor.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000114812 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032528 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: VIPR1 vasoactive intestinal peptide receptor 1".
  6. ↑ Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S (Apr 1992). "Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide". Neuron. 8 (4): 811–9. doi:10.1016/0896-6273(92)90101-I. PMID   1314625. S2CID   43589458.
  7. ↑ Usdin TB, Bonner TI, Mezey E (Dec 1994). "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions". Endocrinology. 135 (6): 2662–80. doi:10.1210/endo.135.6.7988457. PMID   7988457.
  8. ↑ Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ (Mar 1995). "Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene". Proceedings of the National Academy of Sciences of the United States of America. 92 (7): 2939–43. Bibcode:1995PNAS...92.2939S. doi: 10.1073/pnas.92.7.2939 . PMC   42334 . PMID   7708752.
  9. ↑ Nam C, Case AJ, Hostager BS, O'Dorisio MS (Feb 2009). "The role of vasoactive intestinal peptide (VIP) in megakaryocyte proliferation". Journal of Molecular Neuroscience. 37 (2): 160–7. doi:10.1007/s12031-008-9119-x. PMID   18663606. S2CID   2030939.
  10. ↑ Freson K, Peeters K, De Vos R, Wittevrongel C, Thys C, Hoylaerts MF, Vermylen J, Van Geet C (Feb 2008). "PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications". Blood. 111 (4): 1885–93. doi:10.1182/blood-2007-06-098558. PMID   18000164.
  11. ↑ Paladini F, Cocco E, Cascino I, Belfiore F, Badiali D, Piretta L, Alghisi F, Anzini F, Fiorillo MT, Corazziari E, Sorrentino R (Jun 2009). "Age-dependent association of idiopathic achalasia with vasoactive intestinal peptide receptor 1 gene". Neurogastroenterology and Motility. 21 (6): 597–602. doi:10.1111/j.1365-2982.2009.01284.x. PMID   19309439. S2CID   24081228.
  12. ↑ Hong X, Huang L, Song Y (Aug 2008). "Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse". International Urogynecology Journal and Pelvic Floor Dysfunction. 19 (8): 1151–7. doi:10.1007/s00192-008-0585-z. PMID   18351280. S2CID   2482642.

Further reading

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