GPR45

GPR45
Identifiers
Aliases	GPR45 , PSP24, PSP24(ALPHA), PSP24A, G protein-coupled receptor 45
External IDs	OMIM: 604838 MGI: 2135882 HomoloGene: 5228 GeneCards: GPR45
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q12.1 Start 105,241,743 bp [1] End 105,243,467 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 B Start 42,992,032 bp [2] End 43,074,616 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 cingulate gyrus hypothalamus nucleus accumbens amygdala embryo caudate nucleus putamen substantia nigra Top expressed in ganglionic eminence arcuate nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus superior frontal gyrus ventral tegmental area dorsal tegmental nucleus superior colliculus facial motor nucleus nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11250 93690 Ensembl ENSG00000135973 ENSMUSG00000041907 UniProt Q9Y5Y3 Q9EQQ4 RefSeq (mRNA) NM_007227 NM_053107 RefSeq (protein) NP_009158 NP_444337 Location (UCSC) Chr 2: 105.24 – 105.24 Mb Chr 1: 42.99 – 43.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene. ^{[5] [6]}

This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000135973 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041907 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (May 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID   10036181.
6. "Entrez Gene: GPR45 G protein-coupled receptor 45".

Further reading

• Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID   11027574.
• Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID   11027575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.