GPR115

ADGRF4
Identifiers
Aliases	ADGRF4 , PGR18, GPR115, adhesion G protein-coupled receptor F4
External IDs	OMIM: 614268 MGI: 1925499 HomoloGene: 51953 GeneCards: ADGRF4
Gene location (Human)
Chr.	Chromosome 6 (human)
End	47,722,021 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	42,692,284 bp
Gene ontology
Molecular function	• G protein-coupled receptor activity ; • transmembrane signaling receptor activity ; • signal transducer activity ;
Cellular component	• integral component of membrane ; • membrane ;
Biological process	• G protein-coupled receptor signaling pathway ; • cell surface receptor signaling pathway ; • signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	221393
	78249
	ENSG00000153294
	ENSMUSG00000023918
	Q8IZF3
	Q9D2L6
	NM_153838 ; NM_001347855
	NM_001289499 ; NM_001289500 ; NM_001289501 ; NM_030067
	NP_001334784 ; NP_722580
	NP_001276428 ; NP_001276429 ; NP_001276430 ; NP_084343
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2021

Probable G-protein coupled receptor 115 is a protein that in humans is encoded by the GPR115 gene.^[5]^[6]

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Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Integral membrane protein GPR155, also known as G protein-coupled receptor 155, is a protein that in humans is encoded by the GPR155 gene. Mutations in this gene may be associated with autism.

GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.

Probable G-protein coupled receptor 125 is a protein that in humans is encoded by the GPR125 gene.

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene. GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.

Probable G-protein coupled receptor 111 is a protein that in humans is encoded by the GPR111 gene.

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.

Probable G-protein coupled receptor 150 is a protein that in humans is encoded by the GPR150 gene.

Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene. This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 141 is a protein that in humans is encoded by the GPR141 gene.

Probable G-protein coupled receptor 153 is a protein that in humans is encoded by the GPR153 gene.

G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.

Probable G-protein coupled receptor 142 is a protein that in humans is encoded by the GPR142 gene.

G protein-coupled receptor 148, also known as GPR148, is a human orphan receptor from GPCR superfamily. It is expressed primarily in nervous system and testis. Is may be implicated in prostate cancer.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153294 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023918 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi: 10.1016/S0014-5793(02)03574-3 . PMID 12435584. S2CID 7449692.
↑ "Entrez Gene: GPR115 G protein-coupled receptor 115".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC 153653 . PMID 12679517.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000153294 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023918 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12435584-5] Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi: 10.1016/S0014-5793(02)03574-3 . PMID 12435584. S2CID 7449692.

[entrez-6] "Entrez Gene: GPR115 G protein-coupled receptor 115".

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GPR115

Related Research Articles

References

Further reading