P2RY13

P2RY13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6U
Identifiers
Aliases	P2RY13 , GPCR1, GPR86, GPR94, P2Y13, SP174, FKSG77, purinergic receptor P2Y13
External IDs	OMIM: 606380 MGI: 1921441 HomoloGene: 12543 GeneCards: P2RY13
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q25.1 Start 151,326,312 bp [1] End 151,329,549 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 D Start 59,115,313 bp [2] End 59,118,303 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood spleen bone marrow spongy bone bone marrow cells appendix lymph node inferior ganglion of vagus nerve palpebral conjunctiva Top expressed in spleen Region I of hippocampus proper bone marrow visual cortex globus pallidus superior frontal gyrus blood hippocampus proper thymus sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane endoplasmic reticulum membrane Biological process cellular response to organic cyclic compound negative regulation of adenylate cyclase activity signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway G protein-coupled receptor signaling pathway biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53829 74191 Ensembl ENSG00000181631 ENSMUSG00000036362 UniProt Q9BPV8 Q9D8I2 RefSeq (mRNA) NM_023914 NM_176894 NM_028808 RefSeq (protein) NP_795713 NP_083084 Location (UCSC) Chr 3: 151.33 – 151.33 Mb Chr 3: 59.12 – 59.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene. ^{[5] [6] [7]}

The product of this gene, P2Y₁₃, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for this gene. ^[7]

See also

• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000181631 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036362 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wittenberger T, Schaller HC, Hellebrand S (Mar 2001). "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors". J Mol Biol. 307 (3): 799–813. doi:10.1006/jmbi.2001.4520. PMID   11273702.
6. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID   11574155.
7. "Entrez Gene: P2RY13 purinergic receptor P2Y, G-protein coupled, 13".

Further reading

• Communi D, Gonzalez NS, Detheux M, et al. (2001). "Identification of a novel human ADP receptor coupled to G(i)". J. Biol. Chem. 276 (44): 41479–85. doi: 10.1074/jbc.M105912200 . PMID   11546776.
• Zhang FL, Luo L, Gustafson E, et al. (2002). "P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse". J. Pharmacol. Exp. Ther. 301 (2): 705–13. doi:10.1124/jpet.301.2.705. PMID   11961076.
• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi: 10.1016/S0014-5793(02)02775-8 . PMID   12044878. S2CID   7116392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Fabre AC, Malaval C, Ben Addi A, et al. (2010). "P2Y13 receptor is critical for reverse cholesterol transport". Hepatology. 52 (4): 1477–83. doi: 10.1002/hep.23897 . PMID   20830789. S2CID   5833128.

External links

• "P2Y Receptors: P2Y₁₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.