FGF3

FGF3
Identifiers
Aliases	FGF3 , HBGF-3, INT2, fibroblast growth factor 3
External IDs	OMIM: 164950 MGI: 95517 HomoloGene: 3841 GeneCards: FGF3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	69,819,416 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• fibroblast growth factor receptor binding ; • GO:0001948 protein binding ; • growth factor activity ; • Ras guanyl-nucleotide exchange factor activity ; • 1-phosphatidylinositol-3-kinase activity ; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity ; • protein tyrosine kinase activity ;
Cellular component	• extracellular region ; • intracellular ;
Biological process	• cell differentiation ; • cell-cell signaling ; • anatomical structure morphogenesis ; • MAPK cascade ; • multicellular organism development ; • fibroblast growth factor receptor signaling pathway ; • negative regulation of cardiac muscle tissue development ; • positive regulation of cell proliferation ; • positive regulation of cell division ; • signal transduction ; • phosphatidylinositol phosphorylation ; • phosphatidylinositol-3-phosphate biosynthetic process ; • peptidyl-tyrosine phosphorylation ; • regulation of receptor activity ; • positive regulation of protein kinase B signaling ;
	Sources:Amigo / QuickGO
Orthologs
	2248
	14174
	ENSG00000186895
	ENSMUSG00000031074
	P11487
	n/a
	NM_005247
	NM_008007
	NP_005238
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 04, 2020

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.^[4]

Function

FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.^[4]

Clinical significance

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.^[4] Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.

Interactions

FGF3 (gene) has been shown to interact with EBNA1BP2.^[5]

Related Research Articles

FGF2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. It is synthesized primarily as a 155 amino acid polypeptide, resulting in an 18 kDa protein. However, there are four alternate start codons which provide N-terminal extensions of 41, 46, 55, or 133 amino acids, resulting in proteins of 22 kDa, 22.5 kDa, 24 kDa and 34 kDa, respectively. Generally, the 155 aa/18 kDa low molecular weight (LMW) form is considered cytoplasmic and can be secreted from the cell, whereas the high molecular weight (HMW) forms are directed to the cell's nucleus.

FGF1, also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.

Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome.

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334.

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.

Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene.

Glia-activating factor is a protein that in humans is encoded by the FGF9 gene.

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.

Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene.

Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene.

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.

Probable rRNA-processing protein EBP2 is a protein that in humans is encoded by the EBNA1BP2 gene.

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186895 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)".
↑ Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Aug 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226 . PMID 11438656.

Represa J, León Y, Miner C, Giraldez F (1991). "The int-2 proto-oncogene is responsible for induction of the inner ear". Nature. 353 (6344): 561–3. doi:10.1038/353561a0. PMID 1922362. S2CID 1375659.
Brookes S, Smith R, Casey G, Dickson C, Peters G (1989). "Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells". Oncogene. 4 (4): 429–36. PMID 2470007.
Casey G, Smith R, McGillivray D, Peters G, Dickson C (1987). "Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene". Mol. Cell. Biol. 6 (2): 502–10. doi:10.1128/mcb.6.2.502. PMC 367539 . PMID 3023852.
Mansour SL, Goddard JM, Capecchi MR (1993). "Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear". Development. 117 (1): 13–28. PMID 8223243.
Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292–7. doi: 10.1074/jbc.271.25.15292 . PMID 8663044.
Galdemard C, Yamagata H, Brison O, Lavialle C (2000). "Regulation of FGF-3 gene expression in tumorigenic and non-tumorigenic clones of a human colon carcinoma cell line". J. Biol. Chem. 275 (23): 17364–73. doi: 10.1074/jbc.M909316199 . PMID 10749884.
Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226 . PMID 11438656.
Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. doi: 10.1074/jbc.M405795200 . PMID 15199049.
Antoine M, Reimers K, Wirz W, Gressner AM, Müller R, Kiefer P (2006). "Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2". Biochem. Biophys. Res. Commun. 338 (2): 1248–55. doi:10.1016/j.bbrc.2005.10.079. PMID 16263090.
Tekin M, Hişmi BO, Fitoz S, Ozdağ H, Cengiz FB, Sirmaci A, Aslan I, Inceoğlu B, Yüksel-Konuk EB, Yilmaz ST, Yasun O, Akar N (2007). "Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia". Am. J. Hum. Genet. 80 (2): 338–44. doi:10.1086/510920. PMC 1785350 . PMID 17236138.
Riley BM, Mansilla MA, Ma J, Daack-Hirsch S, Maher BS, Raffensperger LM, Russo ET, Vieira AR, Dodé C, Mohammadi M, Marazita ML, Murray JC (2007). "Impaired FGF signaling contributes to cleft lip and palate". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4512–7. doi:10.1073/pnas.0607956104. PMC 1810508 . PMID 17360555.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186895 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] 1 2 3 "Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)".

[pmid11438656-5] Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Aug 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226 . PMID 11438656.

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