FGF6

FGF6
Identifiers
Aliases	FGF6 , HBGF-6, HST2, fibroblast growth factor 6
External IDs	OMIM: 134921 MGI: 95520 HomoloGene: 10870 GeneCards: FGF6
Gene location (Human)
Chr.	Chromosome 12 (human)
End	4,445,815 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	127,005,150 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; skeletal muscle tissue; ; oocyte; ; external globus pallidus; ; secondary oocyte; ; superior frontal gyrus; ; duodenum; ; urinary bladder; ; head; ; exocrine gland;
	Top expressed in
	triceps brachii muscle; ; ankle; ; temporal muscle; ; elbow; ; soleus muscle; ; tibialis anterior muscle; ; sternocleidomastoid muscle; ; gastrocnemius muscle; ; vastus lateralis muscle; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding ; growth factor activity ; protein tyrosine kinase activity ; phosphatidylinositol-4,5-bisphosphate 3-kinase activity ; 1-phosphatidylinositol-3-kinase activity ;
Cellular component	extracellular region ; sarcolemma ; intracellular anatomical structure ; extracellular space ;
Biological process	cell differentiation ; cell-cell signaling ; MAPK cascade ; multicellular organism development ; fibroblast growth factor receptor signaling pathway ; angiogenesis ; positive regulation of cell population proliferation ; cell population proliferation ; myoblast differentiation ; positive regulation of cell division ; cartilage condensation ; signal transduction ; phosphatidylinositol phosphate biosynthetic process ; peptidyl-tyrosine phosphorylation ; phosphatidylinositol-3-phosphate biosynthetic process ; regulation of signaling receptor activity ; positive regulation of protein kinase B signaling ;
	Sources:Amigo / QuickGO
Orthologs
	2251
	14177
	ENSG00000111241
	ENSMUSG00000000183
	P10767
	P21658
	NM_020996
	NM_010204
	NP_066276
	NP_034334
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.^[5]^[6]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.^[6]

Related Research Articles

Fibroblast growth factor 1, (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point mutation in FGFR3 can lead to achondroplasia.

Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334.

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.

Fibroblast growth factor 8(FGF-8) is a protein that in humans is encoded by the FGF8 gene.

Glia-activating factor is a protein that in humans is encoded by the FGF9 gene.

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.

Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene.

Fibroblast growth factor 18 (FGF18) is a protein that is encoded by the Fgf18 gene in humans. The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to Fgf8. The three proteins were eventually grouped into the FGF8 subfamily, which contains several of the endocrine FGF superfamily members FGF8, FGF17, and FGF18. Subsequent studies identified FGF18's role in promoting chondrogenesis, and an apparent specific activity for the generation of the hyaline cartilage in articular joints.

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

Fibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene.

Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene.

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.

Fibroblast growth factor 22 is a protein which in humans is encoded by the FGF22 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111241 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000183 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM (Jun 2006). "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". J Biol Chem. 281 (23): 15694–700. doi: 10.1074/jbc.M601252200 . PMC 2080618 . PMID 16597617.
1 2 "Entrez Gene: FGF6 fibroblast growth factor 6".

Vainikka S, Partanen J, Bellosta P, et al. (1992). "Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction". EMBO J. 11 (12): 4273–80. doi:10.1002/j.1460-2075.1992.tb05526.x. PMC 557000 . PMID 1385111.
Iida S, Yoshida T, Naito K, et al. (1992). "Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization". Oncogene. 7 (2): 303–9. PMID 1549352.
Coulier F, Batoz M, Marics I, et al. (1991). "Putative structure of the FGF6 gene product and role of the signal peptide". Oncogene. 6 (8): 1437–44. PMID 1886714.
Marics I, Adelaide J, Raybaud F, et al. (1989). "Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family". Oncogene. 4 (3): 335–40. PMID 2649847.
Aerssens J, Chaffanet M, Baens M, et al. (1994). "Regional assignment of seven loci to 12p13.2-pter by PCR analysis of somatic cell hybrids containing the der(12) or the der(X) chromosome from a mesothelioma showing t(X;12)(q22;p13)". Genomics. 20 (1): 119–21. doi:10.1006/geno.1994.1136. PMID 8020938.
Ornitz DM, Xu J, Colvin JS, et al. (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292–7. doi: 10.1074/jbc.271.25.15292 . PMID 8663044.
Ropiquet F, Giri D, Kwabi-Addo B, et al. (2000). "Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer". Cancer Res. 60 (15): 4245–50. PMID 10945637.
Duplan SM, Théorêt Y, Kenigsberg RL (2002). "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant". Clin. Cancer Res. 8 (1): 246–57. PMID 11801566.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. doi: 10.1074/jbc.M405795200 . PMID 15199049.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111241 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000183 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16597617-5] Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM (Jun 2006). "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". J Biol Chem. 281 (23): 15694–700. doi: 10.1074/jbc.M601252200 . PMC 2080618 . PMID 16597617.

[entrez-6] 1 2 "Entrez Gene: FGF6 fibroblast growth factor 6".

[1]

[2]

[3]

[4]

[5]

[6]

FGF6

Related Research Articles

References

Further reading