(R)-3-hydroxyacid-ester dehydrogenase

Last updated
(R)-3-hydroxyacid-ester dehydrogenase
Identifiers
EC no. 1.1.1.279
CAS no. 114705-02-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, (R)-3-hydroxyacid-ester dehydrogenase (EC 1.1.1.279) is an enzyme that catalyzes the chemical reaction

 
 
 
H+
(R)-3-hydroxyacid-ester dehydrogenase
 
H+
 
 

The two substrates of this enzyme are ethyl (R)-3-hydroxyhexanoate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are ethyl 3-oxohexanoate, reduced NADPH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase. This enzyme is also called 3-oxo ester (R)-reductase.

See also

References

  1. Enzyme 1.1.1.279 at KEGG Pathway Database.
  2. Heidlas J, Engel KH, Tressl R (1988). "Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast". Eur. J. Biochem. 172 (3): 633–9. doi: 10.1111/j.1432-1033.1988.tb13936.x . PMID   3280313.