(S)-3-hydroxyacid-ester dehydrogenase

(S)-3-hydroxyacid-ester dehydrogenase
Identifiers
EC no.	1.1.1.280
CAS no.	114705-03-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, (S)-3-hydroxyacid-ester dehydrogenase (EC 1.1.1.280) is an enzyme that catalyzes the chemical reaction

ethyl (S)-3-hydroxyhexanoate

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

ethyl 3-oxohexanoate

+ NADPH

 

The two substrates of this enzyme are ethyl (S)-3-hydroxyhexanoate and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are ethyl 3-oxohexanoate, reduced NADPH, and a proton. ^{[1] [2]}

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is ethyl-(S)-3-hydroxyhexanoate:NADP⁺ 3-oxidoreductase. This enzyme is also called 3-oxo ester (S)-reductase.

See also

• (R)-3-hydroxyacid-ester dehydrogenase which acts on the enantiomer of the substrate

References

1. Enzyme 1.1.1.280 at KEGG Pathway Database.
2. Heidlas J, Engel KH, Tressl R (1988). "Purification and characterization of two oxidoreductases involved in the enantioselective reduction of 3-oxo, 4-oxo and 5-oxo esters in baker's yeast". Eur. J. Biochem. 172 (3): 633–9. doi: 10.1111/j.1432-1033.1988.tb13936.x . PMID   3280313.