(S)-carnitine 3-dehydrogenase

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(S)-carnitine 3-dehydrogenase
Identifiers
EC no. 1.1.1.254
CAS no. 169277-49-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, (S)-carnitine 3-dehydrogenase (EC 1.1.1.254) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
(S)-carnitine 3-dehydrogenase
 
H+
 
+ NADH
 

The two substrates of this enzyme are (S)-carnitine and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 3-dehydrocarnitine, reduced NADH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-carnitine:NAD+ oxidoreductase.

References

  1. Enzyme 1.1.1.254 at KEGG Pathway Database.
  2. Setyahadi S, Ueyama T, Arimoto T, Mori N, Kitamoto Y (1997). "Purification and properties of a new enzyme, D-carnitine dehydrogenase, from Agrobacterium sp. 525a". Biosci. Biotechnol. Biochem. 61 (6): 1055–8. doi: 10.1271/bbb.61.1055 . PMID   9214773.