(S)-stylopine synthase

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(S)-stylopine synthase
Identifiers
EC no. 1.14.19.64
CAS no. 138791-29-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, (S)-stylopine synthase (EC 1.14.19.64) is an enzyme that catalyzes the chemical reaction

 
 
O2
2 H2O
(S)-stylopine synthase
 
 
 
 

The three substrates of this enzyme are (S)-cheilanthifoline, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and oxygen. Its products are (S)-stylopine, oxidised NADP+, and water. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is (S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming). This enzyme is also called (S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming). This enzyme participates in alkaloid biosynthesis.

References

  1. Enzyme 1.14.21.1 at KEGG Pathway Database.
  2. Bauer W, Zenk MH (1991). "Two methylenedioxy bridge-forming cytochrome P-450 dependent enzymes are involved in (S)-stylopine biosynthesis". Phytochemistry . 30 (9): 2953–2961. Bibcode:1991PChem..30.2953B. doi:10.1016/S0031-9422(00)98230-X.