2-hydroxy-3-oxopropionate reductase

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2-hydroxy-3-oxopropionate reductase
Identifiers
EC no. 1.1.1.60
CAS no. 9028-68-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, a 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) is an enzyme that catalyzes the chemical reaction

(R)-glycerate + NAD(P)+ 2-hydroxy-3-oxopropanoate + NAD(P)H + H+

The 3 substrates of this enzyme are (R)-glycerate, NAD+, and NADP+, whereas its 4 products are 2-hydroxy-3-oxopropanoate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD(P)+ oxidoreductase. This enzyme is also called tartronate semialdehyde reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1YB4.

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References


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