8-Hydroxygeraniol dehydrogenase

8-Hydroxygeraniol dehydrogenase
Identifiers
EC no.	1.1.1.324
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

8-hydroxygeraniol dehydrogenase (EC 1.1.1.324, 8-hydroxygeraniol oxidoreductase, CYP76B10, G10H, CrG10H, SmG10H, acyclic monoterpene primary alcohol:NADP⁺ oxidoreductase) is an enzyme with systematic name (6E)-8-hydroxygeraniol:NADP+ oxidoreductase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

(6E)-8-hydroxygeraniol + 2 NADP⁺${\displaystyle \rightleftharpoons }$ (6E)-8-oxogeranial + 2 NADPH + 2 H⁺ (overall reaction) ^[3]

8-Hydroxygeraniol

+ 2 NADP⁺

 

 

 

2 H⁺

 

2 H⁺

 

8-Oxogeranial

+ 2 NADPH

 

(1a) (6E)-8-hydroxygeraniol + NADP⁺${\displaystyle \rightleftharpoons }$ (6E)-8-hydroxygeranial + NADPH + H⁺

(1b) (6E)-8-hydroxygeraniol + NADP⁺${\displaystyle \rightleftharpoons }$ (6E)-8-oxogeraniol + NADPH + H⁺

(1c) (6E)-8-hydroxygeranial + NADP⁺${\displaystyle \rightleftharpoons }$ (6E)-8-oxogeranial + NADPH + H⁺

(1d) (6E)-8-oxogeraniol + NADP⁺${\displaystyle \rightleftharpoons }$ (6E)-8-oxogeranial + NADPH + H⁺

This enzyme contains Zn²⁺. It catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol.

References

1. Ikeda H, Esaki N, Nakai S, Hashimoto K, Uesato S, Soda K, Fujita T (February 1991). "Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols". Journal of Biochemistry. 109 (2): 341–7. PMID   1864846.
2. Hallahan DL, West JM, Wallsgrove RM, Smiley DW, Dawson GW, Pickett JA, Hamilton JG (April 1995). "Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa)". Archives of Biochemistry and Biophysics. 318 (1): 105–12. doi:10.1006/abbi.1995.1210. PMID   7726550.
3. Enzyme 1.1.1.324 at KEGG Pathway Database.

External links

• 8-hydroxygeraniol+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)