8-Hydroxygeraniol dehydrogenase

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8-Hydroxygeraniol dehydrogenase
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EC no. 1.1.1.324
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8-hydroxygeraniol dehydrogenase (EC 1.1.1.324, 8-hydroxygeraniol oxidoreductase, CYP76B10, G10H, CrG10H, SmG10H, acyclic monoterpene primary alcohol:NADP+ oxidoreductase) is an enzyme with systematic name (6E)-8-hydroxygeraniol:NADP+ oxidoreductase. [1] [2] This enzyme catalyses the following chemical reaction

(6E)-8-hydroxygeraniol + 2 NADP+ (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction)
(1a) (6E)-8-hydroxygeraniol + NADP+ (6E)-8-hydroxygeranial + NADPH + H+
(1b) (6E)-8-hydroxygeraniol + NADP+ (6E)-8-oxogeraniol + NADPH + H+
(1c) (6E)-8-hydroxygeranial + NADP+ (6E)-8-oxogeranial + NADPH + H+
(1d) (6E)-8-oxogeraniol + NADP+ (6E)-8-oxogeranial + NADPH + H+

This enzyme contains Zn2+. It catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol.

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<span class="mw-page-title-main">NADPH dehydrogenase</span>

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References

  1. ↑ Ikeda H, Esaki N, Nakai S, Hashimoto K, Uesato S, Soda K, Fujita T (February 1991). "Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols". Journal of Biochemistry. 109 (2): 341–7. PMID   1864846.
  2. ↑ Hallahan DL, West JM, Wallsgrove RM, Smiley DW, Dawson GW, Pickett JA, Hamilton JG (April 1995). "Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa)". Archives of Biochemistry and Biophysics. 318 (1): 105–12. doi:10.1006/abbi.1995.1210. PMID   7726550.
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