Adamalysin

Last updated
Adamalysin
Identifiers
EC no. 3.4.24.46
CAS no. 74812-51-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

Adamalysin (EC 3.4.24.46, Crotalus adamanteus metalloendopeptidase, proteinase I and II, Crotalus adamanteus venom proteinase II, adamalysin II) is an enzyme. [1] This enzyme catalyses the following chemical reaction

Contents

Cleavage of Phe1-Val, His5-Leu, His10-Leu, Ala14-Leu, Leu15-Tyr, and Tyr16-Leu of insulin B chain

This enzyme is present in the venom of the eastern diamondback rattlesnake ( Crotalus adamanteus ).

See also

Related Research Articles

<span class="mw-page-title-main">Eastern diamondback rattlesnake</span> Species of reptile endemic to the southeastern US

The eastern diamondback rattlesnake is a species of pit viper in the family Viperidae. The species is endemic to the Southeastern United States. It is one of the heaviest venomous snakes in the Americas and the largest rattlesnake. No subspecies are recognized.

Crotalidae Polyvalent Immune Fab (ovine), sold under the brandname CroFab, is a snake antivenin, indicated for North American Crotalid (Rattlesnake, Copperhead and Cottonmouth/Water moccasin) snake envenomation.

<span class="mw-page-title-main">Myotoxin</span>

Myotoxins are small, basic peptides found in snake venoms and lizard venoms. This involves a non-enzymatic mechanism that leads to severe muscle necrosis. These peptides act very quickly, causing instantaneous paralysis to prevent prey from escaping and eventually death due to diaphragmatic paralysis.

<span class="mw-page-title-main">Pepsin A</span>

Pepsin A is an enzyme. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">L-amino-acid oxidase</span>

In enzymology, an L-amino acid oxidase (LAAO) (EC 1.4.3.2) is an enzyme that catalyzes the chemical reaction

Leucyl endopeptidase is an enzyme. This enzyme catalyses the following chemical reaction

Pycnoporopepsin is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin A is an enzyme that is one of six hemorrhagic toxins found in the venom of western diamondback rattlesnake. This endopeptidase has a length of 419 amino acid residues. The metalloproteinase disintegrin-like domain and the cysteine-rich domain of the enzyme are responsible for the enzyme's hemorrhagic effects on organisms via inhibition of platelet aggregation.

Leucolysin is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin B is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin C is an enzyme. This enzyme catalyses the following chemical reaction

Atroxase is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin E is an enzyme. This enzyme catalyses the following chemical reaction

Atrolysin F is an enzyme. This enzyme catalyses the following chemical reaction

Horrilysin is an enzyme. This enzyme catalyses the following chemical reaction

Ruberlysin is an enzyme. This enzyme catalyses the following chemical reaction

Trimerelysin I is an enzyme. This enzyme catalyses the following chemical reaction

Trimerelysin II is an enzyme. This enzyme catalyses the following chemical reaction

Fibrolase is an enzyme. This enzyme catalyses the following chemical reaction

Jararhagin is an enzyme. This enzyme catalyses the following chemical reaction

References

  1. Kurecki T, Laskowski M, Kress LF (November 1978). "Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human alpha 1-proteinase inhibitor". The Journal of Biological Chemistry. 253 (22): 8340–5. PMID   309470.