MMP21

Last updated
MMP21
Identifiers
Aliases MMP21 , MMP-21, HTX7, matrix metallopeptidase 21
External IDs OMIM: 608416 MGI: 2664387 HomoloGene: 17519 GeneCards: MMP21
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_147191

NM_152944
NM_001320216

RefSeq (protein)

NP_671724

NP_001307145
NP_694423

Location (UCSC) Chr 10: 125.75 – 125.78 Mb Chr 7: 133.28 – 133.28 Mb
PubMed search [3] [4]
Wikidata
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Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene. [5] [6]

Contents

Function

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [6]

Related Research Articles

<span class="mw-page-title-main">TIMP2</span>

Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor.

<span class="mw-page-title-main">MMP7</span>

Matrilysin also known as matrix metalloproteinase-7 (MMP-7), pump-1 protease (PUMP-1), or uterine metalloproteinase is an enzyme in humans that is encoded by the MMP7 gene. The enzyme has also been known as matrin, putative metalloproteinase-1, matrix metalloproteinase pump 1, PUMP-1 proteinase, PUMP, metalloproteinase pump-1, putative metalloproteinase, MMP). Human MMP-7 has a molecular weight around 30 kDa.

<span class="mw-page-title-main">MMP10</span>

Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.

<span class="mw-page-title-main">Matrix metallopeptidase 13</span>

Collagenase 3 is an enzyme that in humans is encoded by the MMP13 gene. It is a member of the matrix metalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive pro-form. MMP-13 has an predicted molecular weight around 54 kDa. It is activated once the pro-domain is cleaved, leaving an active enzyme composed of the catalytic domain and the hemopexin-like domain PDB: 1PEX​. Although the actual mechanism has not been described, the hemopexin domain participates in collagen degradation, the catalytic domain alone being particularly inefficient in collagen degradation. During embryonic development, MMP-13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. In pathological situations it is highly overexpressed; this occurs in human carcinomas, rheumatoid arthritis and osteoarthritis.

<span class="mw-page-title-main">Matrix metallopeptidase 12</span> Enzyme involved in breakdown of extracellular matrix, encoded for by the MMP12 gene in humans

Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene.

<span class="mw-page-title-main">MMP26</span>

Matrix metalloproteinase-26 also known as matrilysin-2 and endometase is an enzyme that in humans is encoded by the MMP26 gene.

<span class="mw-page-title-main">MMP19</span>

Matrix metalloproteinase-19 (MMP-19) also known as matrix metalloproteinase RASI is an enzyme that in humans is encoded by the MMP19 gene.

<span class="mw-page-title-main">MMP11</span>

Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene.

<span class="mw-page-title-main">MMP16</span> Protein-coding gene in the species Homo sapiens

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.

<span class="mw-page-title-main">TIMP4</span>

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.

<span class="mw-page-title-main">GTF3A</span> Protein-coding gene in the species Homo sapiens

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene. It was first isolated and characterized by Wolffe and Brown in 1988.

<span class="mw-page-title-main">MMP17</span>

Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 is an enzyme that in humans is encoded by the MMP17 gene.

<span class="mw-page-title-main">MMP25</span>

Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene.

<span class="mw-page-title-main">MMP28</span> Protein-coding gene in the species Homo sapiens

Matrix metalloproteinase 28 also known as epilysin is an enzyme that in humans is encoded by the MMP28 gene.

<span class="mw-page-title-main">MMP23B</span> Protein-coding gene in the species Homo sapiens

Matrix metalloproteinase-23 is an enzyme that in humans is encoded by the MMP23B gene.

<span class="mw-page-title-main">MMP24</span> Protein-coding gene in the species Homo sapiens

Matrix metalloproteinase-24 is an enzyme that in humans is encoded by the MMP24 gene.

<span class="mw-page-title-main">MMP20</span>

Matrix metalloproteinase-20 (MMP-20) also known as enamel metalloproteinase or enamelysin is an enzyme that in humans is encoded by the MMP20 gene.

<span class="mw-page-title-main">MMP8</span>

Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals. In humans, the MMP-8 protein is encoded by the MMP8 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage.

<span class="mw-page-title-main">ADAM18</span> Protein-coding gene in the species Homo sapiens

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.

<span class="mw-page-title-main">MMP15</span>

Matrix metalloproteinase 15 also known as MMP15 is an enzyme that in humans is encoded by the MMP15 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154485 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030981 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene. 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID   11255011.
  6. 1 2 "Entrez Gene: MMP21 matrix metallopeptidase 21".

Further reading