MMP16

Last updated

MMP16
Protein MMP16 PDB 1rm8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MMP16 , C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP, matrix metallopeptidase 16
External IDs OMIM: 602262; MGI: 1276107; HomoloGene: 55939; GeneCards: MMP16; OMA:MMP16 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005941
NM_022564
NM_032297

NM_019724
NM_001379518
NM_001379519

RefSeq (protein)

NP_005932

NP_062698
NP_001366447
NP_001366448

Location (UCSC) Chr 8: 88.03 – 88.33 Mb Chr 4: 17.85 – 18.12 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene. [5] [6]

Contents

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000156103 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028226 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Takino T, Sato H, Shinagawa A, Seiki M (Nov 1995). "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family". J Biol Chem. 270 (39): 23013–20. doi: 10.1074/jbc.270.39.23013 . PMID   7559440.
  6. 1 2 "Entrez Gene: MMP16 matrix metallopeptidase 16 (membrane-inserted)".

Further reading