ADAM11

ADAM11
Identifiers
Aliases	ADAM11 , MDC, ADAM metallopeptidase domain 11
External IDs	OMIM: 155120; MGI: 1098667; HomoloGene: 7614; GeneCards: ADAM11; OMA:ADAM11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.31 Start 44,758,988 bp [1] End 44,781,846 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 E1|11 66.48 cM Start 102,652,265 bp [2] End 102,671,088 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe prefrontal cortex cingulate gyrus anterior cingulate cortex Brodmann area 9 apex of heart superior frontal gyrus postcentral gyrus primary visual cortex Top expressed in cerebellar cortex primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus lobe of cerebellum liver parenchyma cerebellar vermis hippocampus proper habenula trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding metalloendopeptidase activity metallopeptidase activity Cellular component extracellular matrix integral component of membrane plasma membrane membrane collagen-containing extracellular matrix Biological process integrin-mediated signaling pathway proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4185 11488 Ensembl ENSG00000073670 ENSMUSG00000020926 UniProt O75078 Q9R1V4 RefSeq (mRNA) NM_002390 NM_001318933 NM_001110778 NM_009613 RefSeq (protein) NP_001305862 NP_002381 NP_001104248 NP_033743 Location (UCSC) Chr 17: 44.76 – 44.78 Mb Chr 11: 102.65 – 102.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene. ^{[5] [6]}

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000073670 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020926 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet. 5 (2): 151–7. doi:10.1038/ng1093-151. PMID   8252040. S2CID   11770397.
6. "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11".

Further reading

• Wolfsberg TG, Primakoff P, Myles DG, White JM (1995). "ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell- matrix interactions". J. Cell Biol. 131 (2): 275–8. doi:10.1083/jcb.131.2.275. PMC   2199973 . PMID   7593158.
• Katagiri T, Harada Y, Emi M, Nakamura Y (1994). "Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing". Cytogenet. Cell Genet. 68 (1–2): 39–44. doi:10.1159/000133884. PMID   7956356.
• Sagane K, Ohya Y, Hasegawa Y, Tanaka I (1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". Biochem. J. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC   1219666 . PMID   9693107.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2) R8. doi: 10.1186/gb-2004-5-2-r8 . PMC   395752 . PMID   14759258.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID   15203218.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.976
• Human ADAM11 genome location and ADAM11 gene details page in the UCSC Genome Browser .