U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route. Truckers refer to this road as "The Bee Line."
Illinois Route 19 is a major east–west arterial state highway in northeastern Illinois, United States. It runs from Illinois Route 25 in Elgin, to Lake Shore Drive on the north side of Chicago. Illinois 19 is 33.64 miles (54.14 km) long. For much of its length, it is also known as Irving Park Road and Chicago-Elgin Road.
Illinois Route 43 is a 60.30-mile-long (97.04 km) major north–south state highway in the U.S. state of Illinois. It runs from U.S. Route 30 (US 30) in Frankfort north to the large intersection of IL 120 and US 41 in Waukegan.
Illinois Route 40 is a 112.05-mile-long (180.33 km) north–south route in central portion of the U.S. state of Illinois. It runs from Interstate 74 (I-74) in East Peoria north to IL 78 at Mt. Carroll, just south of U.S. Route 52 and IL 64.
Illinois Route 171 (IL 171) is a 38.61-mile-long (62.14 km) north–south state highway in northeastern Illinois. It runs from U.S. Route 6 (US 6) in Joliet north to Illinois Route 72 at the Chicago–Park Ridge border. The section of IL 171 on Archer Avenue from Joliet to Summit is historically significant, originating as a Native American trail, and later serving for a time as part of the first numbered highway between St. Louis and Chicago.
Illinois Route 56 is a 32.52-mile-long (52.34 km) east–west state highway in northern and northeastern Illinois. It runs from the interchange of Illinois Route 47 at U.S. Route 30 in Sugar Grove east to US 12/US 20/US 45 by Bellwood. It is one of only three state highways that require tolls.
Illinois Route 2 is a north–south state highway in northern Illinois. It currently starts at Illinois Route 40 in Sterling and ends at the Wisconsin state line in South Beloit, very near the intersection with U.S. Route 51, Illinois Route 75 and Illinois Route 251. Illinois 2 is 73.91 miles (118.95 km) long.
Illinois Route 31 (IL 31) is a 58.41-mile-long (94.00 km) north–south state highway in northeastern Illinois, United States. It travels from U.S. Route 34 (US 34) in Oswego north to US 12, near the Wisconsin state line, just south of Richmond.
Illinois Route 4 is a major north–south highway that runs south from the Interstate 55 business loop around the state capital of Springfield, south to Illinois Route 13 just north of Murphysboro. This is a distance of 170.44 miles (274.30 km).
Illinois Route 126 (IL 126) is a 17.25-mile-long (27.76 km) east–west state highway in the northern part of the U.S. state of Illinois. It travels from IL 47 in Yorkville to Interstate 55 (I-55) between Plainfield and Bolingbrook.
Illinois Route 57 is a north–south state highway in western Illinois. It runs from Interstate 172 in Fall Creek to U.S. Route 24 and Illinois Route 104 in Quincy, a distance of 12.59 miles (20.26 km).
U.S. Route 6 (US 6) in the state of Illinois is an east–west arterial surface road that runs 179.88 miles (289.49 km) from the city of Moline in the Quad Cities area to Lansing at the Indiana state line.
U.S. Route 34 (US 34) is an east–west highway In the state of Illinois that runs from the Iowa state line at Gulfport, west of Galesburg, to Illinois Route 43 (IL 43) and Historic U.S. Route 66 at Harlem Avenue in Berwyn. The entire highway in Illinois is named the Walter Payton Memorial Highway after Pro Football Hall of Famer Walter Payton, who wore #34 for the Chicago Bears. The highway is 211.37 miles (340.17 km) long within the state.
Sheridan Road is a major north-south street that leads from Diversey Parkway in Chicago, Illinois, north to the Illinois-Wisconsin border and beyond to Racine. Throughout most of its run, it is the easternmost north-south through street, closest to Lake Michigan. From Chicago, it passes through Chicago's wealthy lakeside North Shore suburbs, and then Waukegan and Zion, until it reaches the Illinois-Wisconsin state line in Winthrop Harbor. In Wisconsin, the road leads north through Pleasant Prairie and Kenosha, until it ends on the south side of Racine, in Mount Pleasant.
U.S. Route 41 (US 41) in the U.S. state of Illinois runs north from the Indiana border beneath the Chicago Skyway on Indianapolis Boulevard to the Wisconsin border north of the northern terminus of the Tri-State Tollway with Interstate 94. It is the only north–south U.S. Route to travel through a significant portion of the city of Chicago, carrying Lake Shore Drive through the central portion of the city along the lakefront. US 41 in Illinois is 64.81 miles (104.30 km) in length.
U.S. Route 54 (US 54) in Illinois is a 23.9-mile-long (38.5 km) east–west highway that travels from the Champ Clark Bridge on the Missouri state line to I-72/US 36/IL 107 south of Griggsville. At its greatest extent, US 54 used to continue east to Springfield, then northeast to Onarga, and then north all the way to Downtown Chicago.
U.S. Route 45 in the state of Illinois is a major north–south U.S. Highway that runs from the Brookport Bridge over the Ohio River at Brookport north through rural sections of eastern Illinois and then through the suburbs of Chicago to the Wisconsin state line east of Antioch. This is a distance of 428.99 miles (690.39 km). US 45 is the longest numbered route in Illinois.
Illinois Route 63 (IL 63) was an east–west state highway in the Chicago metropolitan area. At its latest routing, it traveled from Illinois Route 72 (IL 72) in East Dundee to US 41 in Gurnee.
Illinois Route 65 was an east–west state highway in the Chicago metropolitan area. It traveled from U.S. Route 30 Business in Aurora to US 34 north of Naperville.
Illinois Route 118 (IL 118) was an east–west state highway in Illinois. Located in the Chicago metropolitan area, the route traveled from Elmhurst to Maywood primarily along St. Charles Road.
IL 83 / IL 171 
