Bacteriuria

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Bacteriuria
Other namesBacteruria
Bacteriuria pyuria 4.jpg
Multiple rod-shaped bacteria shown between the larger white blood cells at urinary microscopy from a person with urinary tract infection.
Specialty Emergency medicine, Infectious disease
TypesAsymptomatic, symptomatic [1] [2]
Diagnostic method Urinalysis, urine culture [3]
Differential diagnosis Contamination [1]
TreatmentBased on symptoms or risk factors [3] [4]
FrequencyAsymptomatic: 3% (middle aged women), up to 50% (women in nursing homes) [5]
Symptomatic: up to 10% of women a year [6] [7]

Bacteriuria is the presence of bacteria in urine. [1] Bacteriuria accompanied by symptoms is a urinary tract infection while that without is known as asymptomatic bacteriuria. [1] [2] Diagnosis is by urinalysis or urine culture. [3] Escherichia coli is the most common bacterium found. [1] People without symptoms should generally not be tested for the condition. [3] Differential diagnosis include contamination. [1]

Contents

If symptoms are present, treatment is generally with antibiotics. [3] Bacteriuria without symptoms generally does not require treatment. [4] Exceptions may include pregnant women, those who have had a recent kidney transplant, young children with significant vesicoureteral reflux, and those undergoing surgery of the urinary tract. [3] [4]

Bacteriuria without symptoms is present in about 3% of otherwise healthy middle aged women. [5] In nursing homes rates are as high as 50% among women and 40% in men. [5] In those with a long term indwelling urinary catheter rates are 100%. [5] Up to 10% of women have a urinary tract infection in a given year and half of all women have at least one infection at some point in their lives. [6] [7] There is an increased risk of asymptomatic or symptomatic bacteriuria in pregnancy due to physiological changes that occur in a pregnant women which promotes unwanted pathogen growth in the urinary tract. [8] [9] [10]

Signs and symptoms

Asymptomatic

Asymptomatic bacteriuria is bacteriuria without accompanying symptoms of a urinary tract infection and is commonly caused by the bacterium Escherichia coli. [8] Other potential pathogens are Klebsiella spp., and group B streptococci. [8] [10] It is more common in women, in the elderly, in residents of long-term care facilities, and in people with diabetes, bladder catheters, and spinal cord injuries. [11] People with a long-term Foley catheter always show bacteriuria. Chronic asymptomatic bacteriuria occurs in as many as 50% of the population in long-term care. [12]

There is an association between asymptomatic bacteriuria in pregnant women with low birth weight, preterm delivery, cystitis, infection of the newborn and fetus death. [8] [13] [10] However, most of these studies were graded as poor quality. [8] Bacteriuria in pregnancy also increases the risk of preeclampsia. [13]

Symptomatic

Symptomatic bacteriuria is bacteriuria with the accompanying symptoms of a urinary tract infection (such as frequent urination, painful urination, fever, back pain, abdominal pain and blood in the urine) and includes pyelonephritis or cystitis. [11] The most common cause of urinary tract infections is Escherichia coli .[ citation needed ]

Diagnosis

Testing for bacteriuria is usually performed in people with symptoms of a urinary tract infection. Certain populations that cannot feel or express symptoms of infection are also tested when showing nonspecific symptoms. For example, confusion or other changes in behaviour can be a sign of an infection in the elderly. Screening for asymptomatic bacteriuria in pregnancy is a common routine in many countries, but controversial.[ citation needed ]

Bacteriuria is assumed if a single bacterial species is isolated in a concentration greater than 100,000 colony forming units per millilitre of urine in clean-catch midstream urine specimens. [16] In urine samples obtained from women, there is a risk for bacterial contamination from the vaginal flora. Therefore, in research, usually a second specimen is analysed to confirm asymptomatic bacteriuria in women. For urine collected via bladder catheterization in men and women, a single urine specimen with greater than 100,000 colony forming units of a single species per millilitre is considered diagnostic. [16] The threshold for women displaying UTI symptoms can be as low as 100 colony forming units of a single species per millilitre. However, bacteria below a threshold of 10000 colony forming units per millilitre are usually reported as "no growth" by clinical laboratories. [17] [18]

Using special techniques certain non-disease causing bacteria have also been found in the urine of healthy people. [19] These are part of the resident microbiota. [19]

Screening

Although controversial, many countries including the United States recommend a one time screening for bacteriuria during mid pregnancy. [20] [21] The screening method is by urine culture. [21] Screening non-pregnant adults is recommended against by the United States Preventive Task Force. [21]

Treatment

The decision to treat bacteriuria depends on the presence of accompanying symptoms and comorbidities.

Asymptomatic

Asymptomatic bacteriuria generally does not require treatment. [4] Exceptions include those undergoing surgery of the urinary tract, children with vesicoureteral reflux or others with structural abnormalities of the urinary tract. [4] [22] In many countries, regional guidelines recommend treatment of pregnant women. [8]

There is no indication to treat asymptomatic bacteriuria in diabetics, renal transplant recipients, and in those with spinal cord injuries. [23]

The overuse of antibiotics to treat asymptomatic bacteriuria has many adverse effects [24] such as an increased risk of diarrhea, the spread of antimicrobial resistance, and infection due to Clostridium difficile.

Symptomatic

Symptomatic bacteriuria is synonymous with urinary tract infection and typically treated with antibiotics. Common choices include nitrofurantoin and trimethoprim/sulfamethoxazole.[ citation needed ]

Epidemiology

Rates of asymptomatic bacteriuria [5]
GroupPrevalence (in %)
Healthy premenopausal women1.0 to 5.0
Pregnant women1.9 to 9.5
Postmenopausal women (50 to 70 years of age)2.8 to 8.6
People with diabetes mellitus Women9.0 to 27.0
Men0.7 to 1.0
Older community-dwelling peopleWomen (older than
70 years)		> 15.0
Men3.6 to 19.0
Older long-term care residentsWomen25.0 to 50.0
Men15.0 to 40.0
People with spinal cord injury Intermittent catheter23.0 to 89.0
Sphincterotomy and
condom catheter 		57.0
People undergoing hemodialysis 28.0
People with an indwelling
urinary catheter 		Short-term9.0 to 23.0
Long-term100

Related Research Articles

<span class="mw-page-title-main">Bacterial vaginosis</span> Excessive growth of bacteria in the vagina

Bacterial vaginosis (BV) is a disease of the vagina caused by excessive growth of bacteria. Common symptoms include increased vaginal discharge that often smells like fish. The discharge is usually white or gray in color. Burning with urination may occur. Itching is uncommon. Occasionally, there may be no symptoms. Having BV approximately doubles the risk of infection by a number of sexually transmitted infections, including HIV/AIDS. It also increases the risk of early delivery among pregnant women.

<span class="mw-page-title-main">Chlamydia</span> Sexually transmitted infection caused by the bacterium Chlamydia trachomatis

Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. Most people who are infected have no symptoms. When symptoms do appear they may occur only several weeks after infection; the incubation period between exposure and being able to infect others is thought to be on the order of two to six weeks. Symptoms in women may include vaginal discharge or burning with urination. Symptoms in men may include discharge from the penis, burning with urination, or pain and swelling of one or both testicles. The infection can spread to the upper genital tract in women, causing pelvic inflammatory disease, which may result in future infertility or ectopic pregnancy.

<span class="mw-page-title-main">Urinary tract infection</span> Infection that affects part of the urinary tract

A urinary tract infection (UTI) is an infection that affects part of the urinary tract. When it affects the lower urinary tract it is known as a bladder infection (cystitis) and when it affects the upper urinary tract it is known as a kidney infection (pyelonephritis). Symptoms from a lower urinary tract infection include pain with urination, frequent urination, and feeling the need to urinate despite having an empty bladder. Symptoms of a kidney infection include fever and flank pain usually in addition to the symptoms of a lower UTI. Rarely the urine may appear bloody. In the very old and the very young, symptoms may be vague or non-specific.

<span class="mw-page-title-main">Urinary incontinence</span> Uncontrolled leakage of urine

Urinary incontinence (UI), also known as involuntary urination, is any uncontrolled leakage of urine. It is a common and distressing problem, which may have a large impact on quality of life. It has been identified as an important issue in geriatric health care. The term enuresis is often used to refer to urinary incontinence primarily in children, such as nocturnal enuresis. UI is an example of a stigmatized medical condition, which creates barriers to successful management and makes the problem worse. People may be too embarrassed to seek medical help, and attempt to self-manage the symptom in secrecy from others.

<span class="mw-page-title-main">Urinalysis</span> Array of tests performed on urine

Urinalysis, a portmanteau of the words urine and analysis, is a panel of medical tests that includes physical (macroscopic) examination of the urine, chemical evaluation using urine test strips, and microscopic examination. Macroscopic examination targets parameters such as color, clarity, odor, and specific gravity; urine test strips measure chemical properties such as pH, glucose concentration, and protein levels; and microscopy is performed to identify elements such as cells, urinary casts, crystals, and organisms.

<span class="mw-page-title-main">Hematuria</span> Medical condition

Hematuria or haematuria is defined as the presence of blood or red blood cells in the urine. "Gross hematuria" occurs when urine appears red, brown, or tea-colored due to the presence of blood. Hematuria may also be subtle and only detectable with a microscope or laboratory test. Blood that enters and mixes with the urine can come from any location within the urinary system, including the kidney, ureter, urinary bladder, urethra, and in men, the prostate. Common causes of hematuria include urinary tract infection (UTI), kidney stones, viral illness, trauma, bladder cancer, and exercise. These causes are grouped into glomerular and non-glomerular causes, depending on the involvement of the glomerulus of the kidney. But not all red urine is hematuria. Other substances such as certain medications and foods can cause urine to appear red. Menstruation in women may also cause the appearance of hematuria and may result in a positive urine dipstick test for hematuria. A urine dipstick test may also give an incorrect positive result for hematuria if there are other substances in the urine such as myoglobin, a protein excreted into urine during rhabdomyolysis. A positive urine dipstick test should be confirmed with microscopy, where hematuria is defined by three of more red blood cells per high power field. When hematuria is detected, a thorough history and physical examination with appropriate further evaluation can help determine the underlying cause.

<span class="mw-page-title-main">Nitrofurantoin</span> Antibacterial drug

Nitrofurantoin is an antibacterial medication used to treat urinary tract infections, but it is not as effective for kidney infections. It is taken by mouth.

Dysuria refers to painful or uncomfortable urination.

<span class="mw-page-title-main">Pyelonephritis</span> Medical condition

Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection. Symptoms most often include fever and flank tenderness. Other symptoms may include nausea, burning with urination, and frequent urination. Complications may include pus around the kidney, sepsis, or kidney failure.

<span class="mw-page-title-main">Foley catheter</span> Medical device

In urology, a Foley catheter is a flexible tube that a clinician passes through the urethra and into the bladder to drain urine. It is the most common type of indwelling urinary catheter.

<i>Staphylococcus saprophyticus</i> Species of bacterium

Staphylococcus saprophyticus is a Gram-positive coccus belonging to the genus Staphylococcus. S. saprophyticus is a common cause of community-acquired urinary tract infections.

<span class="mw-page-title-main">Pyuria</span> Medical condition

Pyuria is the condition of urine containing white blood cells or pus. Defined as the presence of 6-10 or more neutrophils per high power field of unspun, voided mid-stream urine, it can be a sign of a bacterial urinary tract infection. Pyuria may be present in people with sepsis, or in older people with pneumonia. Others additionally require discoloration, clouding or change in the smell of urine for a pyuria to be present. Without these additional features, there is said to be leukocyturia.

Leukocyte esterase (LE) is an esterase produced by leukocytes. A leukocyte esterase test is a urine test for the presence of white blood cells and other abnormalities associated with infection.

<span class="mw-page-title-main">Acute prostatitis</span> Serious bacterial infection of the prostate gland

Acute prostatitis is a serious bacterial infection of the prostate gland. This infection is a medical emergency. It should be distinguished from other forms of prostatitis such as chronic bacterial prostatitis and chronic pelvic pain syndrome (CPPS).

<span class="mw-page-title-main">Pathogenic bacteria</span> Disease-causing bacteria

Pathogenic bacteria are bacteria that can cause disease. This article focuses on the bacteria that are pathogenic to humans. Most species of bacteria are harmless and are often beneficial but others can cause infectious diseases. The number of these pathogenic species in humans is estimated to be fewer than a hundred. By contrast, several thousand species are part of the gut flora present in the digestive tract.

<span class="mw-page-title-main">Gonorrhea</span> Sexually transmitted infection

Gonorrhea, colloquially known as the clap, is a sexually transmitted infection (STI) caused by the bacterium Neisseria gonorrhoeae. Infection may involve the genitals, mouth, or rectum. Infected men may experience pain or burning with urination, discharge from the penis, or testicular pain. Infected women may experience burning with urination, vaginal discharge, vaginal bleeding between periods, or pelvic pain. Complications in women include pelvic inflammatory disease and in men include inflammation of the epididymis. Many of those infected, however, have no symptoms. If untreated, gonorrhea can spread to joints or heart valves.

Urologic diseases or conditions include urinary tract infections, kidney stones, bladder control problems, and prostate problems, among others. Some urologic conditions do not affect a person for that long and some are lifetime conditions. Kidney diseases are normally investigated and treated by nephrologists, while the specialty of urology deals with problems in the other organs. Gynecologists may deal with problems of incontinence in women.

<span class="mw-page-title-main">Purple urine bag syndrome</span> Medical condition

Purple urine bag syndrome (PUBS) is a medical syndrome where purple discoloration of urine occurs in people with urinary catheters and co-existent urinary tract infection. Bacteria in the urine produce the enzyme indoxyl sulfatase. This converts indoxyl sulfate in the urine into the red and blue colored compounds indirubin and indigo. The most commonly implicated bacteria are Providencia stuartii, Providencia rettgeri, Klebsiella pneumoniae, Proteus mirabilis, Escherichia coli, Morganella morganii, and Pseudomonas aeruginosa.

<span class="mw-page-title-main">Neonatal infection</span> Human disease

Neonatal infections are infections of the neonate (newborn) acquired during prenatal development or within the first four weeks of life. Neonatal infections may be contracted by mother to child transmission, in the birth canal during childbirth, or after birth. Neonatal infections may present soon after delivery, or take several weeks to show symptoms. Some neonatal infections such as HIV, hepatitis B, and malaria do not become apparent until much later. Signs and symptoms of infection may include respiratory distress, temperature instability, irritability, poor feeding, failure to thrive, persistent crying and skin rashes.

Edward Harold Kass was an American physician, medical school professor, medical researcher in infectious diseases, medical journal editor, and historian of medicine. He is known for his research on toxic shock syndrome and urinary tract infections.

References

  1. 1 2 3 4 5 6 Das KV (2017). Textbook of Medicine: Two Volume Set. JP Medical Ltd. p. 1250. ISBN   9789386056108.
  2. 1 2 Sendi P, Borens O, Wahl P, Clauss M, Uçkay I (2017). "Management of Asymptomatic Bacteriuria, Urinary Catheters and Symptomatic Urinary Tract Infections in Patients Undergoing Surgery for Joint Replacement: A Position Paper of the Expert Group 'Infection' of swissorthopaedics". Journal of Bone and Joint Infection. 2 (3): 154–159. doi:10.7150/jbji.20425. PMC   5592375 . PMID   28894690.
  3. 1 2 3 4 5 6 "Bacterial Urinary Tract Infections (UTIs)". Merck Manuals Professional Edition. May 2016. Retrieved 12 December 2017.
  4. 1 2 3 4 5 Köves B, Cai T, Veeratterapillay R, Pickard R, Seisen T, Lam TB, et al. (December 2017). "Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel". European Urology. 72 (6): 865–868. doi:10.1016/j.eururo.2017.07.014. PMID   28754533.
  5. 1 2 3 4 5 Colgan R, Nicolle LE, McGlone A, Hooton TM (September 2006). "Asymptomatic bacteriuria in adults". American Family Physician. 74 (6): 985–990. PMID   17002033.
  6. 1 2 Salvatore S, Salvatore S, Cattoni E, Siesto G, Serati M, Sorice P, Torella M (June 2011). "Urinary tract infections in women". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 156 (2): 131–136. doi:10.1016/j.ejogrb.2011.01.028. PMID   21349630.
  7. 1 2 Nicolle LE (February 2008). "Uncomplicated urinary tract infection in adults including uncomplicated pyelonephritis". The Urologic Clinics of North America. 35 (1): 1–12, v. doi:10.1016/j.ucl.2007.09.004. PMID   18061019.
  8. 1 2 3 4 5 6 7 Smaill, Fiona M.; Vazquez, Juan C. (25 November 2019). "Antibiotics for asymptomatic bacteriuria in pregnancy". The Cochrane Database of Systematic Reviews. 2019 (11). doi:10.1002/14651858.CD000490.pub4. ISSN   1469-493X. PMC   6953361 . PMID   31765489.
  9. ↑ Awoke N, Tekalign T, Teshome M, Lolaso T, Dendir G, Obsa MS (July 2021). "Bacterial Profile and asymptomatic bacteriuria among pregnant women in Africa: A systematic review and meta analysis". eClinicalMedicine. 37: 100952. doi:10.1016/j.eclinm.2021.100952. PMC   8343252 . PMID   34386744.
  10. 1 2 3 Emami A, Javanmardi F, Pirbonyeh N (August 2020). "Antibiotic resistant profile of asymptomatic bacteriuria in pregnant women: a systematic review and meta-analysis". Expert Review of Anti-Infective Therapy. 18 (8): 807–815. doi:10.1080/14787210.2020.1759420. PMID   32321329. S2CID   216084453.
  11. 1 2 Coussement J, Scemla A, Abramowicz D, Nagler EV, Webster AC (February 2018). "Antibiotics for asymptomatic bacteriuria in kidney transplant recipients". The Cochrane Database of Systematic Reviews. 2018 (2): CD011357. doi:10.1002/14651858.CD011357.pub2. PMC   6491324 . PMID   29390169.
  12. ↑ AMDA – The Society for Post-Acute and Long-Term Care Medicine (February 2014), "Ten Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation , AMDA – The Society for Post-Acute and Long-Term Care Medicine, retrieved 20 April 2015
  13. 1 2 Szweda H, Jóźwik M (2016). "Urinary tract infections during pregnancy - an updated overview". Developmental Period Medicine. 20 (4): 263–272. PMID   28216479.
  14. ↑ Bonkat G, Braissant O, Cai T, Köves B, Bjerklund Johansen TE, Pickard R, Veeratterapillay R (December 2017). "Non-molecular Methods to Detect Bacteriuria Prior to Urological Interventions: A Diagnostic Accuracy Systematic Review". European Urology Focus. 3 (6): 535–537. doi:10.1016/j.euf.2018.03.004. PMID   29627196.
  15. ↑ Iseri E, Biggel M, Goossens H, Moons P, van der Wijngaart W (November 2020). "Digital dipstick: miniaturized bacteria detection and digital quantification for the point-of-care". Lab on a Chip. 20 (23): 4349–4356. doi: 10.1039/D0LC00793E . PMID   33169747.
  16. 1 2 Detweiler K, Mayers D, Fletcher SG (November 2015). "Bacteruria and Urinary Tract Infections in the Elderly". The Urologic Clinics of North America (Review). 42 (4): 561–568. doi:10.1016/j.ucl.2015.07.002. PMID   26475952.
  17. ↑ Hooton TM (March 2012). "Clinical practice. Uncomplicated urinary tract infection". The New England Journal of Medicine. 366 (11): 1028–1037. doi:10.1056/NEJMcp1104429. PMID   22417256.
  18. ↑ Sam, Amir H.; Teo, James T. H. (20 September 2010). Rapid Medicine. Wiley. ISBN   9781405183239. OCLC   874194395.
  19. 1 2 Schneeweiss J, Koch M, Umek W (September 2016). "The human urinary microbiome and how it relates to urogynecology". International Urogynecology Journal. 27 (9): 1307–1312. doi:10.1007/s00192-016-2944-5. PMID   26811114. S2CID   6272587.
  20. ↑ Moore A, Doull M, Grad R, Groulx S, Pottie K, Tonelli M, et al. (July 2018). "Recommendations on screening for asymptomatic bacteriuria in pregnancy". CMAJ. 190 (27): E823–E830. doi:10.1503/cmaj.171325. PMC   6041243 . PMID   29986858.
  21. 1 2 3 Owens DK, Davidson KW, Krist AH, Barry MJ, Cabana M, Caughey AB, et al. (September 2019). "Screening for Asymptomatic Bacteriuria in Adults: US Preventive Services Task Force Recommendation Statement". JAMA. 322 (12): 1188–1194. doi: 10.1001/jama.2019.13069 . PMID   31550038.
  22. ↑ Ramos JA, Salinas DF, Osorio J, Ruano-Ravina A (September 2016). "Antibiotic prophylaxis and its appropriate timing for urological surgical procedures in patients with asymptomatic bacteriuria: A systematic review". Arab Journal of Urology. 14 (3): 234–239. doi:10.1016/j.aju.2016.05.002. PMC   4983160 . PMID   27547467.
  23. ↑ Nicolle LE (March 2014). "Urinary tract infections in special populations: diabetes, renal transplant, HIV infection, and spinal cord injury". Infectious Disease Clinics of North America. 28 (1): 91–104. doi:10.1016/j.idc.2013.09.006. PMID   24484577.
  24. ↑ Zalmanovici Trestioreanu A, Lador A, Sauerbrun-Cutler MT, Leibovici L (April 2015). "Antibiotics for asymptomatic bacteriuria". The Cochrane Database of Systematic Reviews. 4 (6): CD009534. doi:10.1002/14651858.CD009534.pub2. PMC   8407041 . PMID   25851268.
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