Buglossoides arvensis | |
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Scientific classification ![]() | |
Kingdom: | Plantae |
Clade: | Tracheophytes |
Clade: | Angiosperms |
Clade: | Eudicots |
Clade: | Asterids |
Order: | Boraginales |
Family: | Boraginaceae |
Genus: | Buglossoides |
Species: | B. arvensis |
Binomial name | |
Buglossoides arvensis (L.) I.M.Johnst. (1954) | |
Synonyms [1] | |
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Buglossoides arvensis (syn. Lithospermum arvense), known as field gromwell, corn gromwell, bastard alkanet, and stone seed, is a flowering plant of the family Boraginaceae. It is native to Europe and Asia, as far north as Korea, Japan and Russia, and as far south as Afghanistan and northern Pakistan. [2] It is known in other places as an introduced species, including much of North America and Australia. [3] [4]
Three subspecies are accepted. [1]
The European Union has granted the refined oil of the seed of Buglossoides arvensis novel food status and some farmers are growing it [5] commercially in the United Kingdom as a plant-variety patented (PVP) and trademarked cultivar (Ahiflower®). The seed oil contains high levels (63-72%) of omega-3 ALA (c18:3), omega-3 SDA (c18:4), and omega-6 GLA (c18:3) [6] and has GRAS (generally regarded as safe) review status from the US Food and Drug Administration, Canadian ingredient master file (IMF) registration and novel food status, and GMP+ Feed Support Product status in the EU for livestock and companion animals (including for defatted expeller press cake meal). The seed oil also has TGA Australia Complementary Medicines approval status, ANVISA/MAPA Brazil human and animal alimentary use approval, and limited food use approvals in Korea and Japan.
Refined Buglossoides oil has peer-reviewed published human clinical evidence from controlled dietary intervention trials showing up to 400% more efficient omega-3 EPA (c20:5) accrual in circulating cells vs flaxseed oil and has been shown to significantly upregulate the cytokine interleukin-10 (IL-10) in lipopolysaccharide (LPS) stimulated macrophages by +40% vs. control. [7] IL-10 is recognized as one of the immune modulatory signaling cytokines that moderates the inflammatory response after intensive exercise or immune challenge. Further, refined Buglossoides oil has been shown to form omega-3 DHA (C22:6) endogenously with comparable efficiency as pure marine DHA in mammals and maintain DHA levels similarly in the brain and liver. [8] It has also been shown in recent peer-reviewed research to promote live probiotic survival into the small intestine in the TIMS-1 simulated gut [9] and contribute beneficially to anti-neuroinflammation response in vitro [10] and synergistically to improved executive function and cognitive flexibility in healthy adults. [11] Based on its fatty acid composition, refined Buglossoides oil naturally provides the body a more diverse array of anti-inflammatory omega-3 and omega-6 (via GLA) substrates than derive from preformed EPA/DHA sources. These include SDA, ETA (C20:4n-3), GLA, and DGLA (C20:3n-6).
Seeds of Buglossoides have been reported in Ukrainian archeological sites dating back as far as 4000 BC where they were stored in clay pots, however the purpose and usage of the seeds has not been determined. In modern European arable agriculture, Buglossoides often appears as a weed species with poor competitive and non-invasive characteristics.
Omega−3 fatty acids, also called Omega−3 oils, ω−3 fatty acids, Ω-3 Fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs) characterized by the presence of a double bond three atoms away from the terminal methyl group in their chemical structure. They are widely distributed in nature, being important constituents of animal lipid metabolism, and they play an important role in the human diet and in human physiology. The three types of omega−3 fatty acids involved in human physiology are α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). ALA can be found in plants, while DHA and EPA are found in algae and fish. Marine algae and phytoplankton are primary sources of omega−3 fatty acids. DHA and EPA accumulate in fish that eat these algae. Common sources of plant oils containing ALA include walnuts, edible seeds, and flaxseeds as well as hempseed oil, while sources of EPA and DHA include fish and fish oils, and algae oil.
Flax, also known as common flax or linseed, is a flowering plant, Linum usitatissimum, in the family Linaceae. It is cultivated as a food and fiber crop in regions of the world with temperate climates. In 2022, France produced 75% of the world's supply of flax.
Essential fatty acids, or EFAs, are fatty acids that are required by humans and other animals for normal physiological function that cannot be synthesized in the body. As they are not synthesized in the body, the essential fatty acids – alpha-linolenic acid (ALA) and linoleic acid – must be obtained from food or from a dietary supplement. Essential fatty acids are needed for various cellular metabolic processes and for the maintenance and function of tissues and organs. These fatty acids also are precursors to vitamins, cofactors, and derivatives, including prostaglandins, leukotrienes, thromboxanes, lipoxins, and others.
α-Linolenic acid, also known as alpha-linolenic acid (ALA), is an n−3, or omega-3, essential fatty acid. ALA is found in many seeds and oils, including flaxseed, walnuts, chia, hemp, and many common vegetable oils.
Linseed oil, also known as flaxseed oil or flax oil, is a colourless to yellowish oil obtained from the dried, ripened seeds of the flax plant. The oil is obtained by pressing, sometimes followed by solvent extraction.
Hemp oil is oil obtained by pressing hemp seeds. Cold pressed, unrefined hemp oil is dark to clear light green in color, with a nutty flavor. The darker the color, the grassier the flavour. It should not be confused with hash oil, a tetrahydrocannabinol-containing oil made from the Cannabis flower.
gamma-Linolenic acid or GLA is an n−6, or omega-6, fatty acid found primarily in seed oils. When acting on GLA, arachidonate 5-lipoxygenase produces no leukotrienes and the conversion by the enzyme of arachidonic acid to leukotrienes is inhibited.
Linoleic acid (LA) is an organic compound with the formula HOOC(CH2)7CH=CHCH2CH=CH(CH2)4CH3. Both alkene groups are cis. It is a fatty acid sometimes denoted 18:2 (n-6) or 18:2 cis-9,12. A linoleate is a salt or ester of this acid.
Vegetarian nutrition is the set of health-related challenges and advantages of vegetarian diets.
Eicosapentaenoic acid is an omega-3 fatty acid. In physiological literature, it is given the name 20:5(n-3). It also has the trivial name timnodonic acid. In chemical structure, EPA is a carboxylic acid with a 20-carbon chain and five cis double bonds; the first double bond is located at the third carbon from the omega end.
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is an important component of the human brain, cerebral cortex, skin, and retina. It is given the fatty acid notation 22:6(n-3). It can be synthesized from alpha-linolenic acid or obtained directly from maternal milk, fatty fish, fish oil, or algae oil. The consumption of DHA contributes to numerous physiological benefits, including cognition. As a component of neuronal membranes, the function of DHA is to support neuronal conduction and to allow the optimal functioning of neuronal membrane proteins.
Corn oil or maize oil (British) is oil extracted from the germ of corn (maize). Its main use is in cooking, where its high smoke point makes refined corn oil a valuable frying oil. It is also a key ingredient in some margarines. Corn oil is generally less expensive than most other types of vegetable oils.
Stearidonic acid (SDA: C18H28O2; 18:4, n-3) is an ω-3 fatty acid, sometimes called moroctic acid.
Fatty acid desaturases are a family of enzymes that convert saturated fatty acids into unsaturated fatty acids and polyunsaturated fatty acids. For the common fatty acids of the C18 variety, desaturases convert stearic acid into oleic acid. Other desaturases convert oleic acid into linoleic acid, which is the precursor to alpha-linolenic acid, gamma-linolenic acid, and eicosatrienoic acid.
There is a wide variety of fatty acids found in nature. Two classes of fatty acids are considered essential, the omega-3 and omega-6 fatty acids. Essential fatty acids are necessary for humans but cannot be synthesized by the body and must therefore be obtained from food. Omega-3 and omega-6 are used in some cellular signaling pathways and are involved in mediating inflammation, protein synthesis, and metabolic pathways in the human body.
Rhamphospermum arvense, the charlock mustard, field mustard, wild mustard, or just charlock, is an annual or winter annual plant in the family Brassicaceae. It is found in the fields of North Africa, Asia, Europe, and some other areas where it has been transported and naturalized. Pieris rapae, the small white butterfly, and Pieris napi, the green veined white butterfly, are significant consumers of charlock during their larval stages.
A wax ester (WE) is an ester of a fatty acid and a fatty alcohol. Wax esters are the main components of three commercially important waxes: carnauba wax, candelilla wax, and beeswax.
Oxylipins constitute a family of oxygenated natural products which are formed from fatty acids by pathways involving at least one step of dioxygen-dependent oxidation. These small polar lipid compounds are metabolites of polyunsaturated fatty acids (PUFAs) including omega-3 fatty acids and omega-6 fatty acids. Oxylipins are formed by enyzmatic or non-enzymatic oxidation of PUFAs.
Senior dog food diets are pet foods that are catered toward the senior or mature pet population. The senior dog population consists of dogs that are over the age of seven for most dog breeds, though in general large and giant breed dogs tend to reach this life stage earlier when compared to smaller breed dogs. Senior dog foods contain nutrients and characteristics that are used to improve the health of the aging dog. Aging in dogs causes many changes to occur physiologically that will require a change in nutrient composition of their diet.