CENPO

CENPO
Identifiers
Aliases	CENPO , CENP-O, ICEN-36, MCM21R, centromere protein O
External IDs	OMIM: 611504 MGI: 1923800 HomoloGene: 49760 GeneCards: CENPO
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 24,793,136 bp [1] End 24,822,376 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 A1.1|12 2.02 cM Start 4,246,004 bp [2] End 4,284,294 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence secondary oocyte stromal cell of endometrium rectum caudate nucleus putamen nucleus accumbens lymph node prefrontal cortex tibial nerve Top expressed in secondary oocyte spermatocyte otic placode saccule Paneth cell primitive streak cumulus cell renal corpuscle ureter yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component chromosome cytosol chromosome, centromeric region kinetochore nucleoplasm nucleus Mis6-Sim4 complex Biological process centromere complex assembly CENP-A containing chromatin assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79172 52504 Ensembl ENSG00000138092 ENSMUSG00000020652 UniProt Q9BU64 Q8K015 RefSeq (mRNA) NM_001199803 NM_024322 NM_001322101 NM_134046 NM_001361641 RefSeq (protein) NP_001186732 NP_001309030 NP_077298 NP_598807 NP_001348570 Location (UCSC) Chr 2: 24.79 – 24.82 Mb Chr 12: 4.25 – 4.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein O is a protein that in humans is encoded by the CENPO gene. ^{[5] [6] [7]} CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000138092 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020652 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID   16622420. S2CID   26974412.
6. Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID   16622419. S2CID   205286556.
7. "Entrez Gene: CENPO centromere protein O".
8. Hewitt, Chelsee A.; Ling, King-Hwa; Merson, Tobias D.; Simpson, Ken M.; Ritchie, Matthew E.; King, Sarah L.; Pritchard, Melanie A.; Smyth, Gordon K.; Thomas, Tim (2010-07-16). "Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome". PLOS ONE. 5 (7): e11561. Bibcode:2010PLoSO...511561H. doi: 10.1371/journal.pone.0011561 . ISSN   1932-6203. PMC   2905390 . PMID   20661276.

External links

• Human CENPO genome location and CENPO gene details page in the UCSC Genome Browser .

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi: 10.1111/j.1365-2443.2004.00705.x . PMID   15009096. S2CID   21813024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi: 10.1111/j.1365-2443.2006.00969.x . PMID   16716197. S2CID   45931410.