Carnitine 3-dehydrogenase

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carnitine 3-dehydrogenase
Identifiers
EC no. 1.1.1.108
CAS no. 9045-45-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, carnitine 3-dehydrogenase (EC 1.1.1.108) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
Carnitine 3-dehydrogenase
 
H+
 
+ NADH
 

The two substrates of this enzyme are carnitine and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 3-dehydrocarnitine, reduced NADH, and a proton. [1] [2] [3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is carnitine:NAD+ 3-oxidoreductase.

References

  1. Enzyme 1.1.1.108 at KEGG Pathway Database.
  2. Aurich H, Kleber HP, Sorger H, Tauchert H (1968). "Reinigung und Eigenschaften der Carnitindehydrogenase aus Pseudomonas aeruginosa" [Purification and properties of carnitine dehydrogenase from Pseudomonas aeruginosa]. Eur. J. Biochem. (in German). 6 (2): 196–201. doi:10.1111/j.1432-1033.1968.tb00437.x. PMID   4302217.
  3. Schopp W, Sorger H, Kleber HP, Aurich H (1969). "Kinetische Untersuchungen zum Reaktionsmechanismus der Carnitindehydrogenase aus Pseudomonas aeruginosa" [Kinetic studies of the reaction mechanism of carnitine dehydrogenase of Pseudomonas aeruginosa]. Eur. J. Biochem. (in German). 10 (1): 56–60. doi: 10.1111/j.1432-1033.1969.tb00654.x . PMID   4310279.