Cordyceps militaris

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Cordyceps militaris
2010-08-06 Cordyceps militaris 1.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Fungi
Division: Ascomycota
Class: Sordariomycetes
Order: Hypocreales
Family: Cordycipitaceae
Genus: Cordyceps
Species:
C. militaris
Binomial name
Cordyceps militaris
(L.) Fr. (1818)
Synonyms [1]

Clavaria militarisL. (1753)
Sphaeria militaris(L.) J.F. Gmel. (1792)
Cordylia militaris(L.) Fr. (1818)
Hypoxylon militare(L.) Mérat, (1821)
Xylaria militaris(L.) Gray (1821)
Corynesphaera militaris(L.) Dumort. (1822)
Kentrosporium militare(L.) Wallr. (1844)
Torrubia militaris(L.) Tul. & C. Tul. (1865)

Contents

Cordyceps militaris, commonly known as the caterpillar fungus, [2] is a species of fungus in the family Cordycipitaceae, and the type species of the genus Cordyceps , which consists of hundreds of species. [3] The species was originally described by Carl Linnaeus in 1753 as Clavaria militaris. [1] Cordyceps militaris parasitizes insects and is used in traditional Chinese medicine and modern pharmaceuticals.

Description

The fungus forms 1–8 centimetres (123+14 in) high, club-shaped [4] and orange/red fruiting bodies, which grow out of dead underground pupae. The club is covered with the stroma, into which the actual fruit bodies, the perithecia, are inserted. The surface appears roughly punctured. The inner fungal tissue is whitish to pale orange.

Microscopic features

The spores are smooth, hyaline, long-filiform, and often septate. They decompose to maturity in 3–7 μm × 1–1.2 μm sub pores. The asci are long and cylindrical. Sometimes an anamorphic state, which is Isaria , is found. Masses of white mycelia form around the parasitized insect; however, these may not be of the same species.

Similar species

Cordyceps in the wild has more than 400 different species. [5] Similar species include Cordyceps sobolifera, Elaphocordyceps capitata, and Elaphocordyceps ophioglossoides . [4]

Distribution and habitat

Many authors consider C. militaris quite common, spread throughout the Northern Hemisphere, [6] and fruiting bodies appear in Europe from August to November.

Uses

Cordyceps militaris
Information icon.svg
Smooth icon.pngSmooth hymenium
No cap icon.svgNo distinct cap
NA cap icon.svg Hymenium attachment is irregular or not applicable
Bare stipe icon.svg Stipe is bare
Parasitic fungus.svgEcology is parasitic
Mycomorphbox Edible.pngMycomorphbox Inedible.pngEdibility is edible or inedible
A jar of dry C. militaris fruiting body. Cordyceps militaris jar.jpg
A jar of dry C. militaris fruiting body.

C. militaris can be cultivated in a variety of media, including silkworm pupae, rice, and liquid nutrition. [7] [8] It is considered inedible or "probably edible" by North American field guides. [9] [4] In Asia the fruiting body is cooked as a mushroom in dishes like chicken soup, [10] pork bone soup [11] and hot pot.

C. militaris crops can be affected by pathogenic molds that parasitize and kill the fungus. [12] [13]

Research

Cordyceps militaris is well known within the realm of traditional Chinese medicine. [14] Its anti-inflammatory, anti-tumor, and anti-aging properties have been well documented. [14] However, more thorough clinical trials of the fungus are difficult to construct, due to the biological complexity of the fungus. [14] The medicinal properties of C. militaris can be attributed to a number of chemicals within the fungi, including cordycepin, cordymin, and many other extracts. [15] Cordycepin is especially important, with current research investigating ways to expedite the production of the chemical within cordyceps. [16]

C. militaris is a potential carrier of bio-metabolites for herbal drugs. Traditional medicine systems believe it "revitalizes" various systems of the body. [17] In traditional Chinese medicine, this fungus can serve as a cheap substitute for Ophiocordyceps sinensis . Both contain cordycepin. [7] Studies have found that excessive use of C. militaris can exert pressure on the filtering and excretory functions of the liver and kidneys, potentially leading to damage in these organs. [18]

C. militaris contains a protein CMP18 which induces apoptosis in vitro via a mitochondrion-dependent pathway. It is thought that it might be toxic when eaten. Cooking destroys this protein. [19]

The effects of C. militaris on general health is predicted to land it a substantial position in both medicinal areas as well as everyday diets. [20]

Chemistry

Bai & Sheu 2018 found a new protein causing apoptosis. [19] [21] :22 Song et al., 2009 finds microwave-assisted extraction to be a good technique for polysaccharide extraction from this fungus. [21] :196

Like other members of the Cordyceps genus, C. militaris produces the pharmacologically active compound cordycepin. Cordycepin is a nucleoside analogue of adenosine-differing by only a single hydroxyl group. It has been shown to induce apoptosis, reduce inflammation, and inhibit RNA transcription in cell cultures. For these reasons, it is under study for its anti-metastatic properties. [22]

Related Research Articles

<span class="mw-page-title-main">Ascomycota</span> Division or phylum of fungi

Ascomycota is a phylum of the kingdom Fungi that, together with the Basidiomycota, forms the subkingdom Dikarya. Its members are commonly known as the sac fungi or ascomycetes. It is the largest phylum of Fungi, with over 64,000 species. The defining feature of this fungal group is the "ascus", a microscopic sexual structure in which nonmotile spores, called ascospores, are formed. However, some species of Ascomycota are asexual and thus do not form asci or ascospores. Familiar examples of sac fungi include morels, truffles, brewers' and bakers' yeast, dead man's fingers, and cup fungi. The fungal symbionts in the majority of lichens such as Cladonia belong to the Ascomycota.

<span class="mw-page-title-main">Edible mushroom</span> Edible fungi fruit bodies

Edible mushrooms are the fleshy fruit bodies of numerous species of macrofungi. Edibility may be defined by criteria including the absence of poisonous effects on humans and desirable taste and aroma. Mushrooms that have a particularly desirable taste are described as "choice". Edible mushrooms are consumed for their nutritional and culinary value. Mushrooms, especially dried shiitake, are sources of umami flavor.

<span class="mw-page-title-main">Polyporales</span> Order of fungi

The Polyporales are an order of about 1,800 species of fungi in the division Basidiomycota. The order includes some polypores as well as many corticioid fungi and a few agarics. Many species within the order are saprotrophic, most of them wood-rotters. Some genera, such as Ganoderma and Fomes, contain species that attack living tissues and then continue to degrade the wood of their dead hosts. Those of economic importance include several important pathogens of trees and a few species that cause damage by rotting structural timber. Some of the Polyporales are commercially cultivated and marketed for use as food items or in traditional Chinese medicine.

<i>Ophiocordyceps sinensis</i> Species of fungus

Ophiocordyceps sinensis, known colloquially as caterpillar fungus, is an entomopathogenic fungus in the family Ophiocordycipitaceae. It is mainly found in the meadows above 3,500 metres (11,500 ft) on the Tibetan Plateau in Tibet and the Himalayan regions of Bhutan, India, and Nepal. It parasitizes larvae of ghost moths and produces a fruiting body which is valued in traditional Chinese medicine as an aphrodisiac. Caterpillar fungus contains the compound cordycepin, an adenosine derivative. However, the fruiting bodies harvested in nature usually contain high amounts of arsenic and other heavy metals, so they are potentially toxic and sales have been strictly regulated by China's State Administration for Market Regulation since 2016.

<i>Cordyceps</i> Genus of fungi

Cordyceps is a genus of ascomycete fungi that includes over 260 species worldwide, many of which are parasitic. Diverse variants of cordyceps have had more than 1,500 years of use in Chinese medicine. Most Cordyceps species are endoparasitoids, parasitic mainly on insects and other arthropods ; a few are parasitic on other fungi.

<i>Flammulina filiformis</i> Species of edible mushroom

Flammulina filiformis, commonly called enoki mushroom, is a species of edible agaric in the family Physalacriaceae. It is widely cultivated in East Asia, and well known for its role in Japanese and Chinese cuisine. Until recently, the species was considered to be conspecific with the European Flammulina velutipes, but DNA sequencing has shown that the two are distinct.

<span class="mw-page-title-main">Lingzhi (mushroom)</span> Species of fungus

Lingzhi, Ganoderma sichuanense, also known as reishi or Ganoderma lingzhi is a polypore fungus native to East Asia belonging to the genus Ganoderma.

<i>Tremella fuciformis</i> Species of edible fungus

Tremella fuciformis is a species of fungus; it produces white, frond-like, gelatinous basidiocarps. It is widespread, especially in the tropics, where it can be found on the dead branches of broadleaf trees. This fungus is commercially cultivated and is one of the most popular fungi in the cuisine and medicine of China. T. fuciformis is commonly known as snow fungus, snow ear, silver ear fungus, white jelly mushroom, and white cloud ears.

<span class="mw-page-title-main">Sclerotium</span> Mycelial mass

A sclerotium is a compact mass of hardened fungal mycelium containing food reserves. One role of sclerotia is to survive environmental extremes. In some higher fungi such as ergot, sclerotia become detached and remain dormant until favorable growth conditions return. Sclerotia initially were mistaken for individual organisms and described as separate species until Louis René Tulasne proved in 1853 that sclerotia are only a stage in the life cycle of some fungi. Further investigation showed that this stage appears in many fungi belonging to many diverse groups. Sclerotia are important in the understanding of the life cycle and reproduction of fungi, as a food source, as medicine, and in agricultural blight management.

<span class="mw-page-title-main">Cordycepin</span> Chemical compound

Cordycepin, or 3'-deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter by the replacement of the hydroxy group in the 3' position with a hydrogen. It was initially extracted from the fungus Cordyceps militaris, but can now be produced synthetically. It is also found in other Cordyceps species as well as Ophiocordyceps sinensis.

<i>Hericium erinaceus</i> Edible mushroom

Hericium erinaceus, commonly known as lion's mane, yamabushitake, bearded tooth fungus, or bearded hedgehog, is a species of tooth fungus. It tends to grow in a single clump with dangling spines longer than 1 centimetre. It can be mistaken for other Hericium species that grow in the same areas.

<i>Ganoderma applanatum</i> Species of fungus

Ganoderma applanatum is a bracket fungus with a cosmopolitan distribution.

<i>Ophiocordyceps unilateralis</i> Species of fungus

Ophiocordyceps unilateralis, commonly known as zombie-ant fungus, is an insect-pathogenic fungus, discovered by the British naturalist Alfred Russel Wallace in 1859. Zombie ants, infected by the Ophiocordyceps unilateralis fungus, are predominantly found in tropical rainforests.

<i>Wolfiporia extensa</i> Species of fungus

Wolfiporia extensa, commonly known as hoelen, poria, tuckahoe, China root, fu ling, or matsuhodo, is a fungus in the family Polyporaceae. It is a wood-decay fungus but has a subterranean growth habit. It is notable in the development of a large, long-lasting underground sclerotium that resembles a small coconut. This sclerotium, known as Tuckahoe or fu-ling, is not the same as the true tuckahoe used as Indian bread by Native Americans, which is the arrow arum, Peltandra virginica, a flowering tuberous plant in the arum family.

<span class="mw-page-title-main">Fungus</span> Biological kingdom, separate from plants and animals

A fungus is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as one of the traditional eukaryotic kingdoms, along with Animalia, Plantae, and either Protista or Protozoa and Chromista.

<i>Ophiocordyceps</i> Genus of fungi

Ophiocordyceps is a genus of fungi within the family Ophiocordycipitaceae. The widespread genus, first described scientifically by British mycologist Tom Petch in 1931, contains about 140 species that grow on insects. Anamorphic genera that correspond with Ophiocordyceps species are Hirsutella, Hymenostilbe, Isaria, Paraisaria, and Syngliocladium.

<i>Tolypocladium ophioglossoides</i> Species of fungus

Tolypocladium ophioglossoides, also known by two of its better known synonyms Elaphocordyceps ophioglossoides and Cordyceps ophioglossoides and commonly known as the goldenthread cordyceps, is a species of fungus in the family Ophiocordycipitaceae. It is parasitic on fruit bodies of the truffle-like Elaphomyces. The species is considered inedible, but is valued in traditional Chinese medicine.

Medicinal fungi are fungi that contain metabolites or can be induced to produce metabolites through biotechnology to develop prescription drugs. Compounds successfully developed into drugs or under research include antibiotics, anti-cancer drugs, cholesterol and ergosterol synthesis inhibitors, psychotropic drugs, immunosuppressants and fungicides.

<i>Cordyceps gunnii</i> Species of fungus

Cordyceps gunni is a species of fungus in the family Cordycipitaceae, and is of the genus Cordyceps. It was originally found and recorded by Gunn in Tasmania and named as Sphaeria gunnii and later moved into the Cordyceps genus and renamed Cordyceps gunnii. This fungus and its sisters in the genus Cordyceps are known for growing out of insect bodies. C. gunnii can be found at ground level poking out of caterpillar burrows, attached to a caterpillar's head.

<i>Isaria cicadae</i> Species of fungi

Isaria cicadae is an ascomycete fungus that parasitizes cicada larvae. It forms white and yellow asexual fruiting structures resembling synnema. While mostly being found throughout Asia in warm, humid regions, it has been found on various other continents. It is known in Traditional Chinese Medicine as Chan Hua and commonly called “cicada flower.” Its medicinal uses date back to the fifth century AD in China. It can also be used in various foods and tonics.

References

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