D-sorbitol dehydrogenase (acceptor)

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D-sorbitol dehydrogenase (acceptor)
Identifiers
EC no. 1.1.99.21
CAS no. 9028-22-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, D-sorbitol dehydrogenase (acceptor) (EC 1.1.99.21) is an enzyme that catalyzes the chemical reaction

 
 
 
D-sorbitol dehydrogenase (acceptor)
 
 
 
+ reduced acceptor
 

The two substrates of this enzyme are D-sorbitol and an electron acceptor. Its products are L-sorbose (shown in open-chain keto form) and the corresponding reduced acceptor. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-sorbitol:acceptor 1-oxidoreductase. This enzyme is also called D-sorbitol:(acceptor) 1-oxidoreductase. This enzyme participates in fructose and mannose metabolism. It employs one cofactor, FAD.

References

  1. Enzyme 1.1.99.21 at KEGG Pathway Database.
  2. Shinagawa E, Ameyama M (1982). "Purification and characterization of D-sorbitol dehydrogenase from membrane of Gluconobacter suboxydans var-alpha". Agric. Biol. Chem. 46: 135–141. doi: 10.1271/bbb1961.46.135 .