Fluorodopa

Last updated

Fluorodopa
Fluorodopa.png
Clinical data
Trade names Fluorodopa F18
Other names6-fluoro-L-DOPA, FDOPA
License data
Routes of
administration 		Intravenous
ATC code
Legal status
Legal status
Identifiers
  • (2S)-2-amino-3-(2-(18F)fluoranyl-4,5-dihydroxyphenyl)propanoic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C9H10FNO4
Molar mass 214.18 g·mol−1
3D model (JSmol)
  • C1=C(C(=CC(=C1O)O)F)CC(C(=O)O)N
  • InChI=1S/C9H10FNO4/c10-5-3-8(13)7(12)2-4(5)1-6(11)9(14)15/h2-3,6,12-13H,1,11H2,(H,14,15)/t6-/m0/s1/i10-1
  • Key:PAXWQORCRCBOCU-RPDRGXCHSA-N

Fluorodopa, also known as FDOPA, is a fluorinated form of L-DOPA primarily synthesized as its fluorine-18 isotopologue for use as a radiotracer in positron emission tomography (PET). [1]

Contents

The most common side effects are injection site pain. [2]

Medical uses

Fluorodopa is indicated for use in positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adults with suspected Parkinsonian syndromes (PS). [2]

History

In October 2019, Fluorodopa was approved in the United States for the visual detection of certain nerve cells in adult patients with suspected Parkinsonian Syndromes (PS). [3] [4]

The U.S. Food and Drug Administration (FDA) approved Fluorodopa F 18 based on evidence from one clinical trial of 56 patients with suspected PS. [3] The trial was conducted at one clinical site in the United States. [3]

References

  1. ↑ Deng WP, Wong KA, Kirk KL (June 2002). "Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA". Tetrahedron: Asymmetry. 13 (11): 1135–1140. doi:10.1016/S0957-4166(02)00321-X.
  2. 1 2 "Fluorodopa F18 injection". DailyMed. 12 October 2019. Retrieved 26 April 2020.
  3. 1 2 3 "Drug Trials Snapshots: Fluorodopa F 18". U.S. Food and Drug Administration (FDA). 27 November 2019. Archived from the original on 27 November 2019. Retrieved 27 November 2019.PD-icon.svg This article incorporates text from this source, which is in the public domain .
  4. ↑ "Drug Approval Package: Fluorodopa F18". U.S. Food and Drug Administration (FDA). 20 November 2019. Archived from the original on 27 November 2019. Retrieved 26 November 2019.PD-icon.svg This article incorporates text from this source, which is in the public domain .
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