Fluorodopa

Fluorodopa
Clinical data
Trade names	Fluorodopa F18
Other names	6-fluoro-L-DOPA, FDOPA
License data	US DailyMed: Fluorodopa ;
Routes of; administration	Intravenous
ATC code	V09IX05 ( WHO );
Legal status
Legal status	US: ℞-only ;
Identifiers
	IUPAC name (2S)-2-amino-3-(2-(18F)fluoranyl-4,5-dihydroxyphenyl)propanoic acid;
CAS Number	92812-82-3 ;
PubChem CID	56494 ;
DrugBank	DB13848 ;
ChemSpider	50970 ;
UNII	2C598205QX ;
KEGG	D04220 ;
ChEBI	CHEBI:49166 ;
ChEMBL	ChEMBL3400972 ;
CompTox Dashboard (EPA)	DTXSID90226257 ;
Chemical and physical data
Formula	C9H10FNO4
Molar mass	214.18 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES C1=C(C(=CC(=C1O)O)F)CC(C(=O)O)N;
	InChI InChI=1S/C9H10FNO4/c10-5-3-8(13)7(12)2-4(5)1-6(11)9(14)15/h2-3,6,12-13H,1,11H2,(H,14,15)/t6-/m0/s1/i10-1; Key:PAXWQORCRCBOCU-RPDRGXCHSA-N;

Last updated January 30, 2023

Fluorodopa, also known as FDOPA, is a fluorinated form of L-DOPA primarily synthesized as its fluorine-18 isotopologue for use as a radiotracer in positron emission tomography (PET).^[1]

Medical uses

Fluorodopa is indicated for use in positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adults with suspected Parkinsonian syndromes (PS).^[2]

History

In October 2019, Fluorodopa was approved in the United States for the visual detection of certain nerve cells in adult patients with suspected Parkinsonian Syndromes (PS).^[3]^[4]

The U.S. Food and Drug Administration (FDA) approved Fluorodopa F 18 based on evidence from one clinical trial of 56 patients with suspected PS.^[3] The trial was conducted at one clinical site in the United States.^[3]

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References

↑ Deng WP, Wong KA, Kirk KL (June 2002). "Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA". Tetrahedron: Asymmetry. 13 (11): 1135–1140. doi:10.1016/S0957-4166(02)00321-X.
1 2 "Fluorodopa F18 injection". DailyMed. 12 October 2019. Retrieved 26 April 2020.
1 2 3 "Drug Trials Snapshots: Fluorodopa F 18". U.S. Food and Drug Administration (FDA). 27 November 2019. Archived from the original on 27 November 2019. Retrieved 27 November 2019. This article incorporates text from this source, which is in the public domain .
↑ "Drug Approval Package: Fluorodopa F18". U.S. Food and Drug Administration (FDA). 20 November 2019. Archived from the original on 27 November 2019. Retrieved 26 November 2019. This article incorporates text from this source, which is in the public domain .

External links

"Fluorodopa F 18". Drug Information Portal. U.S. National Library of Medicine.

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[Deng_2002-1] Deng WP, Wong KA, Kirk KL (June 2002). "Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA". Tetrahedron: Asymmetry. 13 (11): 1135–1140. doi:10.1016/S0957-4166(02)00321-X.

[Fluorodopa_F18_FDA_label-2] 1 2 "Fluorodopa F18 injection". DailyMed. 12 October 2019. Retrieved 26 April 2020.

[FDA_Snapshot-3] 1 2 3 "Drug Trials Snapshots: Fluorodopa F 18". U.S. Food and Drug Administration (FDA). 27 November 2019. Archived from the original on 27 November 2019. Retrieved 27 November 2019. This article incorporates text from this source, which is in the public domain .

[4] "Drug Approval Package: Fluorodopa F18". U.S. Food and Drug Administration (FDA). 20 November 2019. Archived from the original on 27 November 2019. Retrieved 26 November 2019. This article incorporates text from this source, which is in the public domain .

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