Rubidium-82 chloride

Rubidium-82 chloride

Names
IUPAC name Rubidium-82 chloride
Systematic IUPAC name (82Rb)Rubidium chloride
Identifiers
CAS Number	132486-03-4  Y
3D model (JSmol)	Interactive image
ChemSpider	64457  Y
KEGG	D05773  Y
PubChem CID	71357
UNII	F0Z746KRKQ  Y
CompTox Dashboard (EPA)	DTXSID60894902
InChI InChI=1S/ClH.Rb/h1H;/q;+1/p-1/i;1-3 Y Key: FGDZQCVHDSGLHJ-RYDPDVNUSA-M Y
SMILES [Cl-].[82Rb+]
Properties
Chemical formula	ClRb
Molar mass	117.371 g mol−1
Pharmacology
ATC code	V09GX04 ( WHO )
Related compounds
Other cations	Caesium chloride Lithium chloride Potassium chloride Rubidium chloride Sodium chloride
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Rubidium-82 chloride is a form of rubidium chloride containing a radioactive isotope of rubidium. It is marketed under the brand name Cardiogen-82 by Bracco Diagnostics for use in Myocardial perfusion imaging. ^[1] It is rapidly taken up by heart muscle cells, and therefore can be used to identify regions of heart muscle that are receiving poor blood flow in a technique called PET perfusion imaging. ^[2] The half-life of rubidium-82 is only 1.26 minutes; it is normally produced at the place of use by rubidium generators. ^[3]

References

1. Wackers, Frans J. Th.; Bruni, Wendy; Zaret, Barry L. (2007-11-19). "Rubidium-82 Generator". Nuclear cardiology: the basics: how to set up and maintain a laboratory. Springer. ISBN   978-1-58829-924-6.
2. Ballinger, James R. (2009). "PET Radiopharmaceuticals in Nuclear Cardiology: Current Status and Limitations". Integrating Cardiology for Nuclear Medicine Physicians. pp. 379–385. doi:10.1007/978-3-540-78674-0_32. ISBN   978-3-540-78673-3.
3. Gould, K. Lance; Goldstein, Richard A.; Mullani, Nizar A.; Kirkeeide, Richard L.; Wong, Wai-Hoi; Tewson, Timothy J.; Berridge, Marc S.; Bolomey, Leonard A.; Hartz, Ross K.; Smalling, Richard W.; Fuentes, Francisco; Nishikawa, Akira (1986). "Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. Clinical feasibility of positron cardiac imaging without a cyclotron using generator-produced Rubidium-82". Journal of the American College of Cardiology. 7 (4): 775–789. doi: 10.1016/S0735-1097(86)80336-9 . PMID   3485669.

Further reading

• Clarke, Michael J; Sadler, P. J (1999-06-15). Metallopharmaceuticals: Diagnosis and therapy. Springer. ISBN   978-3-540-65308-0. (Note: only about 1/2 page on Rb-generator)
• Alvarez-Diez, T; Dekemp, R; Beanlands, R; Vincent, J (1999). "Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography". Applied Radiation and Isotopes. 50 (6): 1015–23. Bibcode:1999AppRI..50.1015A. doi:10.1016/S0969-8043(98)00170-5. PMID   10355104.
• Waters, S. L.; Coursey, B. M., eds. (1987). "The Strontium-82/rubidium-82 generator". International Journal of Radiation Applications and Instrumentation A. 38 (3): 171–239.