Iotroxic acid

Last updated
Iotroxic acid
Iotroxic acid.png
Clinical data
Trade names Biliscopin, others
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
  • 3-{2-[2-(2-{[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]methoxy}ethoxy)ethoxy]acetamido}-2,4,6-triiodobenzoic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.051.726 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C22H18I6N2O9
Molar mass 1215.818 g·mol−1
3D model (JSmol)
  • O=C(Nc1c(I)c(c(I)cc1I)C(=O)O)COCCOCCOCC(=O)Nc2c(I)c(C(=O)O)c(I)cc2I

Iotroxic acid (trade name Biliscopin), used in the form of meglumine iotroxate, is a molecule used as a contrast medium during X-rays. [1] [2] It is specifically used during tests looking at the gallbladder and biliary tract. [2] It is given by slow injection into a vein. [2]

Side effects are uncommon. [3] They include vomiting, skin flushing, headache, itchiness, and low blood pressure. [2] Rare side effects include seizures and allergic reactions. [2] It should not be used by those who have an iodine allergy. [2] Iotroxic acid is an iodine containing contrast media of the diionic dimer type. [4]

Iotroxic acid was first made in 1976. [5] It is on the World Health Organization's List of Essential Medicines. [6] It is rarely used in the developed world due to the availability of magnetic resonance cholangiopancreatography (MRCP). [7]

References

  1. ↑ "Iotroxic Acid". Drugs.com. Archived from the original on 31 December 2016. Retrieved 31 December 2016.
  2. 1 2 3 4 5 6 Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 315, 318. hdl: 10665/44053 . ISBN   978-92-4-154765-9.
  3. ↑ Neugebauer E, Sauerland S (2014). "Diagnosis and treatment of common bile duct stones". Recommendations for evidence-based endoscopic surgery: The updated EAES consensus development conferences. Springer Science & Business Media. p. 67. ISBN   978-2-8178-0849-9. Archived from the original on 2017-01-01.
  4. ↑ Schaefer C, Peters PW, Miller RK (2014). "Iodine containing contrast media". Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment. Academic Press. p. 532. ISBN   978-0-12-407901-4. Archived from the original on 2017-01-01.
  5. ↑ Korolkovas A (1988). Essentials of Medicinal Chemistry. Wiley. p. 1063. ISBN   978-0-471-88356-2. Archived from the original on 2017-01-01.
  6. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. hdl: 10665/325771 . WHO/MVP/EMP/IAU/2019.06.
  7. ↑ Sherlock S, Dooley J (2008). "Imaging of the Biliary Tract: Interventional Radiology and Endoscopy". Diseases of the Liver and Biliary System. John Wiley & Sons. p. 568. ISBN   978-0-470-98681-3. Archived from the original on 2017-01-01.


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