Ioxitalamic acid

Last updated
Ioxitalamic acid
Ioxitalamic acid.png
Ioxitalamic-acid-3D-spacefill.png
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
  • 3-acetamido-5-[(2-hydroxyethyl)carbamoyl]-2,4,6-triiodobenzoic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.044.428 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C12H11I3N2O5
Molar mass 643.93955 g·mol−1
3D model (JSmol)
  • CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NCCO)I
  • InChI=1S/C12H11I3N2O5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22)
  • Key:OLAOYPRJVHUHCF-UHFFFAOYSA-N

Ioxitalamic acid (brand name Telebrix) is a pharmaceutical drug used as an iodinated contrast medium for X-ray imaging. [1] [2] It is used in form of its salts, ioxitalamate sodium and ioxitalamate meglumine. [3]

Related Research Articles

<span class="mw-page-title-main">Lidocaine</span> Local anesthetic

Lidocaine, also known as lignocaine and sold under the brand name Xylocaine among others, is a local anesthetic of the amino amide type. It is also used to treat ventricular tachycardia. When used for local anaesthesia or in nerve blocks, lidocaine typically begins working within several minutes and lasts for half an hour to three hours. Lidocaine mixtures may also be applied directly to the skin or mucous membranes to numb the area. It is often used mixed with a small amount of adrenaline (epinephrine) to prolong its local effects and to decrease bleeding.

<span class="mw-page-title-main">Monoclonal antibody</span> Antibodies from clones of the same blood cell

A monoclonal antibody is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.

A suppository is a dosage form used to deliver medications by insertion into a body orifice, where it dissolves or melts to exert local or systemic effects. There are three types of suppositories, each to insert into a different sections: rectal suppositories into the rectum, vaginal suppositories into the vagina, and urethral suppositories into the urethra of a male.

<span class="mw-page-title-main">Liposome</span> Composite structures made of phospholipids and may contain small amounts of other molecules

A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, liposomes can be used as drug delivery vehicles for administration of pharmaceutical drugs and nutrients, such as lipid nanoparticles in mRNA vaccines, and DNA vaccines. Liposomes can be prepared by disrupting biological membranes.

Radiocontrast agents are substances used to enhance the visibility of internal structures in X-ray-based imaging techniques such as computed tomography, projectional radiography, and fluoroscopy. Radiocontrast agents are typically iodine, or more rarely barium sulfate. The contrast agents absorb external X-rays, resulting in decreased exposure on the X-ray detector. This is different from radiopharmaceuticals used in nuclear medicine which emit radiation.

<span class="mw-page-title-main">Ivermectin</span> Medication for parasite infestations

Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications.

<span class="mw-page-title-main">Iodinated contrast</span> Substance to enhance X-ray imaging

Iodinated contrast is a form of water-soluble, intravenous radiocontrast agent containing iodine, which enhances the visibility of vascular structures and organs during radiographic procedures. Some pathologies, such as cancer, have particularly improved visibility with iodinated contrast.

<span class="mw-page-title-main">Contrast-enhanced ultrasound</span> Medical imaging technique

Contrast-enhanced ultrasound (CEUS) is the application of ultrasound contrast medium to traditional medical sonography. Ultrasound contrast agents rely on the different ways in which sound waves are reflected from interfaces between substances. This may be the surface of a small air bubble or a more complex structure. Commercially available contrast media are gas-filled microbubbles that are administered intravenously to the systemic circulation. Microbubbles have a high degree of echogenicity. There is a great difference in echogenicity between the gas in the microbubbles and the soft tissue surroundings of the body. Thus, ultrasonic imaging using microbubble contrast agents enhances the ultrasound backscatter, (reflection) of the ultrasound waves, to produce a sonogram with increased contrast due to the high echogenicity difference. Contrast-enhanced ultrasound can be used to image blood perfusion in organs, measure blood flow rate in the heart and other organs, and for other applications.

Lipiodol, also known as ethiodized oil, is a poppyseed oil used by injection as a radio-opaque contrast agent that is used to outline structures in radiological investigations. It is used in chemoembolization applications as a contrast agent in follow-up imaging. Lipiodol is also used in lymphangiography, the imaging of the lymphatic system. It has an additional use in gastric variceal obliteration as a dilutant that does not affect polymerization of cyanoacrylate.

<span class="mw-page-title-main">Gadopentetic acid</span> Complex of gadolinium by DTPA

Gadopentetic acid, sold under the brand name Magnevist, is a gadolinium-based MRI contrast agent.

<span class="mw-page-title-main">Perflubron</span> Chemical compound

Perflubron is a contrast medium for magnetic resonance imaging, computer tomography and sonography. It was approved for this use in the United States by the Food and Drug Administration in 1993.

Iodixanol, sold under the brand name Visipaque, is an iodine-containing non-ionic radiocontrast agent.

<span class="mw-page-title-main">Gadodiamide</span> Chemical compound

Gadodiamide, sold under the brand name Omniscan, is a gadolinium-based MRI contrast agent (GBCA), used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.

Lymphography is a medical imaging technique in which a radiocontrast agent is injected, and then an X-ray picture is taken to visualise structures of the lymphatic system, including lymph nodes, lymph ducts, lymphatic tissues, lymph capillaries and lymph vessels. Lymphangiography is the same procedure, used only to visualize the lymph vessels. The x-ray film or image of the lymphatic vessels and lymph nodes is called a lymphogram or a lymphangiogram.

<span class="mw-page-title-main">Iodamide</span> Chemical compound

Iodamide is a pharmaceutical drug used as an iodinated contrast medium for X-ray imaging. Its uses include imaging of the uterus and fallopian tubes.

<span class="mw-page-title-main">Methiodal</span> Chemical compound

Methiodal is a pharmaceutical drug that was used as an iodinated contrast medium for X-ray imaging. Its uses included myelography ; for this use, cases of adhesive arachnoiditis have been reported, similar to those seen under the contrast medium iofendylate.

<span class="mw-page-title-main">Iobitridol</span> Pharmaceutical drug

Iobitridol is a pharmaceutical drug used as an iodine-based radiocontrast agent in X-ray imaging. It is injected into blood vessels, joints, or body cavities such as the uterus, and filtered out by the kidneys. Its most common adverse effect is nausea. Severe allergic reactions are rare.

<span class="mw-page-title-main">Acetrizoic acid</span> Chemical compound

Acetrizoic acid is a pharmaceutical drug that was used as an iodinated contrast medium for X-ray imaging. It was applied in form of its salt, sodium acetrizoate, but is no longer in clinical use.

<span class="mw-page-title-main">Iocarmic acid</span> Chemical compound

Iocarmic acid is a pharmaceutical drug used as an iodinated contrast medium for X-ray imaging in the 1970s and 80s. Uses included imaging of the uterus and fallopian tubes. It was applied in form of its salt, meglumine iocarmate.

<span class="mw-page-title-main">Iocetamic acid</span> Chemical compound

Iocetamic acid is a pharmaceutical drug taken by mouth and used as an iodinated contrast medium for X-ray imaging of the gall bladder.

References

  1. Wiggli U (January 1979). "[Clinical study of the tolerance for 2 iodine containing contrast media for computerized tomography of the skull]". Schweizerische Medizinische Wochenschrift. 109 (2): 51–4. PMID   370976.
  2. El-Garawani I, Hassab El-Nabi S, El Kattan A, Sallam A, Elballat S, Abou-Ghanima S, et al. (February 2021). "The Ameliorative Role of Acacia senegal Gum against the Oxidative Stress and Genotoxicity Induced by the Radiographic Contrast Medium (Ioxitalamate) in Albino Rats". Antioxidants. 10 (2): 221. doi: 10.3390/antiox10020221 . PMC   7912984 . PMID   33540787.
  3. International Drug Names : Telebrix. Accessed 2021-03-31.