Gadoteridol

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Gadoteridol
Gadoteridol.svg
Clinical data
Other names(10-(2-(hydroxy-κO)propyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3)-κN1,κN4,κN7,κN10,κO1,κO4,κO7)-gadolinium
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administration
IV
ATC code
Legal status
Legal status
Identifiers
  • gadolinium(+3) cation; 2-[4-(2-hydroxypropyl)-7,10-bis(2-oxido-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate
CAS Number
PubChem CID
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UNII
KEGG
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ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C17H29GdN4O7
Molar mass 558.69 g·mol−1
3D model (JSmol)
  • [Gd+3].[O-]C(=O)CN1CCN(CCN(CCN(CC(O)C)CC1)CC([O-])=O)CC([O-])=O
  • InChI=1S/C17H32N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26;/h14,22H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28);/q;+3/p-3 Yes check.svgY
  • Key:DPNNNPAKRZOSMO-UHFFFAOYSA-K Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Gadoteridol (INN) is a gadolinium-based MRI contrast agent, used particularly in the imaging of the central nervous system. It is sold under the brand name ProHance. [1] Gadoteridol was first approved for use in the United States in 1992. [2]

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References

  1. Bracco Diagnostic Inc. (26 October 2022). "Gadoteridol (ProHance) prescribing information". DailyMed. U.S. National Library of Medicine . Retrieved 17 May 2023.
  2. Morgan DE, Spann JS, Lockhart ME, Winningham B, Bolus DN (April 2011). "Assessment of adverse reaction rates during gadoteridol-enhanced MR imaging in 28,078 patients". Radiology . 259 (1): 109–16. doi:10.1148/radiol.10100906. PMID   21248237. Specifically, the rate of nausea (0.530%) was less than half the rate (1.4%) in clinical trials of 1251 patients, leading to FDA approval in 1992.