Ketosteroid monooxygenase

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Ketosteroid monooxygenase
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EC no. 1.14.13.54
CAS no. 9044-53-5
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Ketosteroid monooxygenase (EC 1.14.13.54, steroid-ketone monooxygenase, progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing), 17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving), androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)) is an enzyme with systematic name ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing). [1] [2] [3] This enzyme catalyses the following chemical reaction

ketosteroid + NADPH + H+ + O2 steroid ester/lactone + NADP+ + H2O (general reaction)
(1) progesterone + NADPH + H+ + O2 testosterone acetate + NADP+ + H2O
(2) androstenedione + NADPH + H+ + O2 testololactone + NADP+ + H2O
(3) 17alpha-hydroxyprogesterone + NADPH + H+ + O2 androstenedione + acetate + NADP+ + H2O

Ketosteroid monooxygenase is a single FAD-containing enzyme that catalyses three types of monooxygenase reaction.

Related Research Articles

In enzymology, a 3,9-dihydroxypterocarpan 6a-monooxygenase (EC 1.14.13.28) is an enzyme that catalyzes the chemical reaction

In enzymology, an androst-4-ene-3,17-dione monooxygenase (EC 1.14.99.12) is an enzyme that catalyzes the chemical reaction

In enzymology, a cyclopentanone monooxygenase (EC 1.14.13.16) is an enzyme that catalyzes the chemical reaction

In enzymology, a flavonoid 3'-monooxygenase (EC 1.14.14.82, was wrongly classified as EC 1.14.13.21 in the past) is an enzyme that catalyzes the chemical reaction

In enzymology, a leukotriene-E4 20-monooxygenase (EC 1.14.13.34) is an enzyme that catalyzes the chemical reaction

In enzymology, a progesterone 11alpha-monooxygenase (EC 1.14.99.14) is an enzyme that catalyzes the chemical reaction

In enzymology, a (S)-limonene 3-monooxygenase (EC 1.14.13.47) is an enzyme that catalyzes the chemical reaction

In enzymology, a (S)-limonene 6-monooxygenase (EC 1.14.13.48) is an enzyme that catalyzes the chemical reaction

In enzymology, a (S)-limonene 7-monooxygenase (EC 1.14.13.49) is an enzyme that catalyzes the chemical reaction

In enzymology, a steroid 17alpha-monooxygenase (EC 1.14.99.9) is an enzyme that catalyzes the chemical reaction

In enzymology, a taxane 10beta-hydroxylase (EC 1.14.13.76) is an enzyme that catalyzes the chemical reaction

5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (EC 1.3.1.3, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase. This enzyme catalyses the following chemical reaction

Pentachlorophenol monooxygenase (EC 1.14.13.50, pentachlorophenol dechlorinase, pentachlorophenol dehalogenase, pentachlorophenol 4-monooxygenase, PCP hydroxylase, pentachlorophenol hydroxylase, PcpB, PCB 4-monooxygenase, PCB4MO) is an enzyme with systematic name pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating). This enzyme catalyses the following chemical reaction

Epi-isozizaene 5-monooxygenase (EC 1.14.13.106, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating). This enzyme catalyses the following chemical reaction

Isoleucine N-monooxygenase (EC 1.14.13.117, CYP79D3, CYP79D4) is an enzyme with systematic name L-isoleucine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

Valine N-monooxygenase (EC 1.14.13.118, CYP79D1, CYP79D2) is an enzyme with systematic name L-valine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

Phenylalanine N-monooxygenase (EC 1.14.14.40, phenylalanine N-hydroxylase, CYP79A2) is an enzyme with systematic name L-phenylalanine,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

Tryptophan N-monooxygenase (EC 1.14.13.125, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction

Amorpha-4,11-diene 12-monooxygenase (EC 1.14.13.158, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating). This enzyme catalyses the following chemical reaction

Steroid 15beta-monooxygenase (EC 1.14.15.8, cytochrome P-450meg, cytochrome P450meg, steroid 15beta-hydroxylase, CYP106A2, BmCYP106A2) is an enzyme with systematic name progesterone,reduced-ferredoxin:oxygen oxidoreductase (15beta-hydroxylating) . This enzyme catalyses the following chemical reaction

References

  1. ↑ Katagiri M, Itagaki E (1991). "A steroid ketone monooxygenase from Cylindrocarpon radicicola". In Muller F (ed.). Chemistry and Biochemistry of Flavoenzymes. Florida: CRC Press. pp. 102–108.
  2. ↑ Itagaki E (March 1986). "Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization". Journal of Biochemistry. 99 (3): 815–24. PMID   3486863.
  3. ↑ Itagaki E (March 1986). "Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Oxygenative lactonization of androstenedione to testololactone". Journal of Biochemistry. 99 (3): 825–32. PMID   3486864.
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