L-arabinitol 4-dehydrogenase

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L-arabinitol 4-dehydrogenase
3m6i.jpg
L-arabinitol 4-dehydrogenase homotetramer, Neurospora crassa
Identifiers
EC no. 1.1.1.12
CAS no. 9028-19-7
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ExPASy NiceZyme view
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MetaCyc metabolic pathway
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In enzymology, a L-arabinitol 4-dehydrogenase (EC 1.1.1.12) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
Biochem reaction arrow reversible NYYN horiz med.svg
 
H+
 
+ NADH
 

The two substrates are L-arabinitol and oxidised nicotinamide adenine dinucleotide (NAD+). The products are L-xylulose, reduced cofactor NADH, and a proton. [1]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arabinitol:NAD+ 4-oxidoreductase (L-xylulose-forming). Other names in common use include pentitol-DPN dehydrogenase, and L-arabitol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions. [2] [3]

See also

References

  1. Enzyme 1.1.1.12 at KEGG Pathway Database.
  2. Chiang C, Knight SG (1960). "A new pathway of pentose metabolism". Biochem. Biophys. Res. Commun. 3 (5): 554–9. Bibcode:1960BBRC....3..554C. doi:10.1016/0006-291X(60)90174-1. PMID   13692998.
  3. Chiang C, Knight SG (1961). "L-Arabinose metabolism by cell-free extracts of Penicillium chrysogenum". Biochim. Biophys. Acta. 46 (2): 271–8. doi:10.1016/0006-3002(61)90750-8. PMID   13692999.